Tired But Wired? You're Stuck in THIS Loop

I eat perfectly. I exercise six times a I eat perfectly. I exercise six times a week. I try to get to bed on time and week. I try to get to bed on time and week. I try to get to bed on time and sleep. I'm feeling depleted. And I think sleep. I'm feeling depleted. And I think sleep. I'm feeling depleted. And I think people are in this state and they don't people are in this state and they don't people are in this state and they don't have a name for it. But you call it the have a name for it. But you call it the have a name for it. But you call it the sympathetic spiral of doom. sympathetic spiral of doom. sympathetic spiral of doom. >> And it's a loop. You have sympathetic >> And it's a loop. You have sympathetic >> And it's a loop. You have sympathetic activation, which is your fight activation, which is your fight activation, which is your fight orflight, your nervous system being orflight, your nervous system being orflight, your nervous system being activated. You have mitochondrial activated. You have mitochondrial activated. You have mitochondrial dysfunction. The challenge is anytime dysfunction. The challenge is anytime dysfunction. The challenge is anytime you try to downregulate your nervous you try to downregulate your nervous you try to downregulate your nervous system, it actually might make you feel system, it actually might make you feel system, it actually might make you feel like you're crashing. People feel like like you're crashing. People feel like like you're crashing. People feel like they crash when they go down and try to they crash when they go down and try to they crash when they go down and try to do their breath work, try to do their do their breath work, try to do their do their breath work, try to do their meditation. oftentimes they feel meditation. oftentimes they feel meditation. oftentimes they feel terrible when they try to do it if they terrible when they try to do it if they terrible when they try to do it if they can even do it in the first place. can even do it in the first place. can even do it in the first place. You've only been able to function You've only been able to function You've only been able to function because you've been at that high of a because you've been at that high of a because you've been at that high of a state. state. state. >> You can't meditate your way out of this >> You can't meditate your way out of this >> You can't meditate your way out of this like physiological stress to your cells like physiological stress to your cells like physiological stress to your cells and mitochondria is what you're saying, and mitochondria is what you're saying, and mitochondria is what you're saying, right? So, what do we do if someone's right? So, what do we do if someone's right? So, what do we do if someone's stuck? What's the first step to getting stuck? What's the first step to getting stuck? What's the first step to getting out of this loop? out of this loop? out of this loop? >> Today on the podcast, I'm joined by Dr. >> Today on the podcast, I'm joined by Dr. >> Today on the podcast, I'm joined by Dr. Scott Sher. He is a board-certified Scott Sher. He is a board-certified Scott Sher. He is a board-certified physician and a pioneer in health physician and a pioneer in health physician and a pioneer in health optimization medicine. As an expert in optimization medicine. As an expert in optimization medicine. As an expert in mitochondrial function and the chief mitochondrial function and the chief mitochondrial function and the chief medical officer of transcriptions, he's medical officer of transcriptions, he's medical officer of transcriptions, he's helping people break the sympathetic helping people break the sympathetic helping people break the sympathetic stress loop to rapidly restore energy, stress loop to rapidly restore energy, stress loop to rapidly restore energy, focus, and resilience. focus, and resilience. focus, and resilience. Hey, it's Dr. Heyman. I'm so excited to Hey, it's Dr. Heyman. I'm so excited to Hey, it's Dr. Heyman. I'm so excited to share this episode with you today. But share this episode with you today. But share this episode with you today. But before we dive in, I want to get your before we dive in, I want to get your before we dive in, I want to get your help. Please take a minute to hit that help. Please take a minute to hit that help. 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So, thanks so much for being part of this community and I'm being part of this community and I'm being part of this community and I'm glad you're here. glad you're here. glad you're here. >> Welcome back to the podcast, Scott. So >> Welcome back to the podcast, Scott. So >> Welcome back to the podcast, Scott. So good to have you. good to have you. good to have you. >> Well, thanks for having me, Mark. Last >> Well, thanks for having me, Mark. Last >> Well, thanks for having me, Mark. Last time it was online. Today, it's in time it was online. Today, it's in time it was online. Today, it's in person. person. person. >> Yeah, it was online. We talked about >> Yeah, it was online. We talked about >> Yeah, it was online. We talked about hyperbaric oxygen and today we're going hyperbaric oxygen and today we're going hyperbaric oxygen and today we're going to talk about a really important topic to talk about a really important topic to talk about a really important topic which uh honestly affects so many which uh honestly affects so many which uh honestly affects so many people, including me. people, including me. people, including me. And I, you know, I never heard it quite And I, you know, I never heard it quite And I, you know, I never heard it quite described like this, but you call it the described like this, but you call it the described like this, but you call it the sympathetic spiral of doom. Bum. sympathetic spiral of doom. Bum. sympathetic spiral of doom. Bum. >> Yes, exactly. It needs music after >> Yes, exactly. It needs music after >> Yes, exactly. It needs music after >> and you know at first I was like a god >> and you know at first I was like a god >> and you know at first I was like a god that's kind of hyperbolic whatever and that's kind of hyperbolic whatever and that's kind of hyperbolic whatever and then I started reading about it. then I started reading about it. then I started reading about it. >> Yeah. >> Yeah. >> Yeah. >> I'm like oh this is what it is. It's >> I'm like oh this is what it is. It's >> I'm like oh this is what it is. It's it's basically the way in which your it's basically the way in which your it's basically the way in which your system breaks down from too much stress system breaks down from too much stress system breaks down from too much stress from your life and your psychology but from your life and your psychology but from your life and your psychology but also too much stress from the also too much stress from the also too much stress from the environment. You call this top down environment. You call this top down environment. You call this top down bottom up. So environment would be bottom up. So environment would be bottom up. So environment would be toxins and infections and all the stuff toxins and infections and all the stuff toxins and infections and all the stuff that we're exposed to, that we're exposed to, that we're exposed to, >> right? >> right? >> right? >> And it and it creates a breakdown in our >> And it and it creates a breakdown in our >> And it and it creates a breakdown in our ability to regulate our nervous system ability to regulate our nervous system ability to regulate our nervous system >> and and then it influences our >> and and then it influences our >> and and then it influences our mitochondrial function which kind of mitochondrial function which kind of mitochondrial function which kind of makes it worse. So the body's this big makes it worse. So the body's this big makes it worse. So the body's this big web network or everything's connected, web network or everything's connected, web network or everything's connected, right? right? right? >> And so you're kind of unangling the web >> And so you're kind of unangling the web >> And so you're kind of unangling the web through telling this story in kind of a through telling this story in kind of a through telling this story in kind of a new way. It's an old story. We all we new way. It's an old story. We all we new way. It's an old story. We all we all know that stress is bad for us, all know that stress is bad for us, all know that stress is bad for us, right? But like this is a very different right? But like this is a very different right? But like this is a very different frame of it and I and I love it and I frame of it and I and I love it and I frame of it and I and I love it and I think it's going to help a lot of people think it's going to help a lot of people think it's going to help a lot of people because you have to be systematic about because you have to be systematic about because you have to be systematic about it and a lot of us are feeling burned it and a lot of us are feeling burned it and a lot of us are feeling burned out like we're doing everything like I out like we're doing everything like I out like we're doing everything like I eat perfectly. I exercise six times a eat perfectly. I exercise six times a eat perfectly. I exercise six times a week. I try to get to bed on time and week. I try to get to bed on time and week. I try to get to bed on time and sleep and it's just you know but some sleep and it's just you know but some sleep and it's just you know but some just I'm I'm feeling depleted and I just I'm I'm feeling depleted and I just I'm I'm feeling depleted and I think a lot of people out there are think a lot of people out there are think a lot of people out there are probably feeling that. And I think probably feeling that. And I think probably feeling that. And I think people are in this state and they don't people are in this state and they don't people are in this state and they don't have a name for it and they just feel have a name for it and they just feel have a name for it and they just feel like crap and they don't know what's like crap and they don't know what's like crap and they don't know what's going on. they're exhausted, they're going on. they're exhausted, they're going on. they're exhausted, they're wired, they're anxious, they're burned wired, they're anxious, they're burned wired, they're anxious, they're burned out. And today really want to like have out. And today really want to like have out. And today really want to like have people who are listening to understand, people who are listening to understand, people who are listening to understand, you know, what what is going on with you know, what what is going on with you know, what what is going on with their their energy, what is going on their their energy, what is going on their their energy, what is going on with stress, and what what are the with stress, and what what are the with stress, and what what are the psychological and the physiological psychological and the physiological psychological and the physiological causes of stress? And how do we start causes of stress? And how do we start causes of stress? And how do we start kind of navigating this from a kind of navigating this from a kind of navigating this from a therapeutic perspective? Because like we therapeutic perspective? Because like we therapeutic perspective? Because like we all want out of this. I as soon as like, all want out of this. I as soon as like, all want out of this. I as soon as like, yeah, I'm in this empathetic spiral of yeah, I'm in this empathetic spiral of yeah, I'm in this empathetic spiral of doom and I want the hell out of this doom and I want the hell out of this doom and I want the hell out of this thing. So what what is it? Explain it to thing. So what what is it? Explain it to thing. So what what is it? Explain it to us. unpack it for us. us. unpack it for us. us. unpack it for us. >> Well, thanks again for having me, Mark. >> Well, thanks again for having me, Mark. >> Well, thanks again for having me, Mark. And and you know what I what I like to And and you know what I what I like to And and you know what I what I like to just describe here is it's not a just describe here is it's not a just describe here is it's not a diagnosis for people. This is more of a diagnosis for people. This is more of a diagnosis for people. This is more of a pattern as you mentioned. It's an pattern as you mentioned. It's an pattern as you mentioned. It's an age-old pattern. But I realized recently age-old pattern. But I realized recently age-old pattern. But I realized recently that it was really a significant that it was really a significant that it was really a significant discovery for me to understand that it's discovery for me to understand that it's discovery for me to understand that it's a spiral and it's a loop. You have a spiral and it's a loop. You have a spiral and it's a loop. You have sympathetic activation, which is your sympathetic activation, which is your sympathetic activation, which is your fight orflight, your nervous system fight orflight, your nervous system fight orflight, your nervous system being activated. You have mitochondrial being activated. You have mitochondrial being activated. You have mitochondrial dysfunction. Mitochondrial dysfunction. dysfunction. Mitochondrial dysfunction. dysfunction. Mitochondrial dysfunction. Mitochondria as all your listeners know Mitochondria as all your listeners know Mitochondria as all your listeners know is a part of our cells that make energy. is a part of our cells that make energy. is a part of our cells that make energy. The combination of sympathetic The combination of sympathetic The combination of sympathetic activation, mitochondrial dysfunction is activation, mitochondrial dysfunction is activation, mitochondrial dysfunction is a loop. And what happens here is that a loop. And what happens here is that a loop. And what happens here is that this loop can either start with this loop can either start with this loop can either start with mitochondrial dysfunction directly. mitochondrial dysfunction directly. mitochondrial dysfunction directly. That's what I call bottom up. Or it can That's what I call bottom up. Or it can That's what I call bottom up. Or it can start with sympathetic activation from start with sympathetic activation from start with sympathetic activation from outside stressors. Say it's your job, outside stressors. Say it's your job, outside stressors. Say it's your job, your relationship. You have a snoring your relationship. You have a snoring your relationship. You have a snoring partner that is snoring and you can't partner that is snoring and you can't partner that is snoring and you can't get to sleep at night. Outside stresses get to sleep at night. Outside stresses get to sleep at night. Outside stresses or even like worse things like trauma or or even like worse things like trauma or or even like worse things like trauma or things that happened when you were things that happened when you were things that happened when you were younger that have maintained you in this younger that have maintained you in this younger that have maintained you in this place where you can't stay safe. Either place where you can't stay safe. Either place where you can't stay safe. Either way, whether it either starts with way, whether it either starts with way, whether it either starts with mitochondrial dysfunction directly or it mitochondrial dysfunction directly or it mitochondrial dysfunction directly or it starts with sympathetic activation starts with sympathetic activation starts with sympathetic activation externally or for most people it's both. externally or for most people it's both. externally or for most people it's both. Yeah. And then it's something that just Yeah. And then it's something that just Yeah. And then it's something that just makes you fall off a cliff. It could be makes you fall off a cliff. It could be makes you fall off a cliff. It could be >> Well, let me let me pause you for a sec. >> Well, let me let me pause you for a sec. >> Well, let me let me pause you for a sec. Just define sympathetic activation Just define sympathetic activation Just define sympathetic activation because people are what what is that? because people are what what is that? because people are what what is that? And define like a little bit better And define like a little bit better And define like a little bit better mitochondria because these are these are mitochondria because these are these are mitochondria because these are these are central to your thesis of the central to your thesis of the central to your thesis of the sympathetic. So, let's get our terms sympathetic. So, let's get our terms sympathetic. So, let's get our terms right cuz I think people like right cuz I think people like right cuz I think people like >> otherwise you'll be just be talking. >> otherwise you'll be just be talking. >> otherwise you'll be just be talking. >> I'm sympathetic, you know. I'm >> I'm sympathetic, you know. I'm >> I'm sympathetic, you know. I'm sympathetic. No, no, no. It's not that. sympathetic. No, no, no. It's not that. sympathetic. No, no, no. It's not that. >> Yeah. No, good point. So, yeah. So, I >> Yeah. No, good point. So, yeah. So, I >> Yeah. No, good point. So, yeah. So, I feel sympathetic to those that are in feel sympathetic to those that are in feel sympathetic to those that are in sympathetic. The sympathetic nervous sympathetic. The sympathetic nervous sympathetic. The sympathetic nervous system. So, sympathetic is your fight system. So, sympathetic is your fight system. So, sympathetic is your fight orflight part of your nervous system. orflight part of your nervous system. orflight part of your nervous system. So, it's your it's running away from the So, it's your it's running away from the So, it's your it's running away from the proverbial saber-tooth tiger as we proverbial saber-tooth tiger as we proverbial saber-tooth tiger as we somehow always refer to. I don't know somehow always refer to. I don't know somehow always refer to. I don't know why, but you're getting chased by why, but you're getting chased by why, but you're getting chased by something. But unfortunately, we're something. But unfortunately, we're something. But unfortunately, we're getting chased all the time in modern getting chased all the time in modern getting chased all the time in modern society. whether it's with our phones society. whether it's with our phones society. whether it's with our phones that are actively in our faces all the that are actively in our faces all the that are actively in our faces all the time and doom scrolling at 3:00 in the time and doom scrolling at 3:00 in the time and doom scrolling at 3:00 in the morning going why is this the way it is morning going why is this the way it is morning going why is this the way it is um or it's outside things like your job um or it's outside things like your job um or it's outside things like your job or your relationship but we're not we or your relationship but we're not we or your relationship but we're not we don't reward people resting and don't reward people resting and don't reward people resting and relaxing. So the sympathetic nervous relaxing. So the sympathetic nervous relaxing. So the sympathetic nervous system is part of your autonomic nervous system is part of your autonomic nervous system is part of your autonomic nervous system. You have your sympathetic branch system. You have your sympathetic branch system. You have your sympathetic branch which is your activation fight or flight which is your activation fight or flight which is your activation fight or flight and you have your parasympathetic which and you have your parasympathetic which and you have your parasympathetic which is your rest digest detoxify and heal. is your rest digest detoxify and heal. is your rest digest detoxify and heal. But But But >> modern society doesn't reward that side, >> modern society doesn't reward that side, >> modern society doesn't reward that side, right? It rewards the hustle. I mean, in right? It rewards the hustle. I mean, in right? It rewards the hustle. I mean, in medical school, my friends and I had medical school, my friends and I had medical school, my friends and I had shirts that said, "Sleep is for shirts that said, "Sleep is for shirts that said, "Sleep is for quitters." quitters." quitters." >> Yeah. >> Yeah. >> Yeah. >> Not surprising, right? I grew up in New >> Not surprising, right? I grew up in New >> Not surprising, right? I grew up in New York. York. York. >> Surgeons don't have lunch. That was >> Surgeons don't have lunch. That was >> Surgeons don't have lunch. That was ours. ours. ours. >> Yeah. There you go. Same kind of thing. >> Yeah. There you go. Same kind of thing. >> Yeah. There you go. Same kind of thing. Like, you just you hustle, right? You go Like, you just you hustle, right? You go Like, you just you hustle, right? You go and you grind, right? That's what we and you grind, right? That's what we and you grind, right? That's what we reward. And then unfortunately that's reward. And then unfortunately that's reward. And then unfortunately that's how society has created this stress how society has created this stress how society has created this stress externally for us that we have to externally for us that we have to externally for us that we have to perform, we have to have more meetings, perform, we have to have more meetings, perform, we have to have more meetings, we have to do more, do more, do more all we have to do more, do more, do more all we have to do more, do more, do more all the time. And so instead of just running the time. And so instead of just running the time. And so instead of just running away from the saber-tooth tiger and away from the saber-tooth tiger and away from the saber-tooth tiger and then, you know, hanging out the rest of then, you know, hanging out the rest of then, you know, hanging out the rest of the day because hopefully we lived, the day because hopefully we lived, the day because hopefully we lived, maybe we probably didn't, but in some maybe we probably didn't, but in some maybe we probably didn't, but in some cases we did, right? cases we did, right? cases we did, right? >> Then you would have the time to relax >> Then you would have the time to relax >> Then you would have the time to relax because your nervous system would be because your nervous system would be because your nervous system would be activated and then it' be shut off. But activated and then it' be shut off. But activated and then it' be shut off. But that's not how modern society works that's not how modern society works that's not how modern society works anymore. As you know, we're constantly anymore. As you know, we're constantly anymore. As you know, we're constantly stressed, constantly on pressure, stressed, constantly on pressure, stressed, constantly on pressure, constantly on meetings. And that's that constantly on meetings. And that's that constantly on meetings. And that's that sympathetic activation. And most of us sympathetic activation. And most of us sympathetic activation. And most of us kind of think we thrive in that in that kind of think we thrive in that in that kind of think we thrive in that in that environment. And we can for a little environment. And we can for a little environment. And we can for a little while. But the problem is that when while. But the problem is that when while. But the problem is that when you're sympathetic all the time, you're you're sympathetic all the time, you're you're sympathetic all the time, you're releasing hormones like cortisol, your releasing hormones like cortisol, your releasing hormones like cortisol, your neurotransmitters like norepinephrine neurotransmitters like norepinephrine neurotransmitters like norepinephrine and epinephrine, and epinephrine, and epinephrine, >> adrenaline. >> adrenaline. >> adrenaline. >> And adrenaline. Yes. Nor neurogrenaline, >> And adrenaline. Yes. Nor neurogrenaline, >> And adrenaline. Yes. Nor neurogrenaline, adrenaline that are stimulating the adrenaline that are stimulating the adrenaline that are stimulating the whole system to work harder. Because if whole system to work harder. Because if whole system to work harder. Because if you're in that sympathetic nervous you're in that sympathetic nervous you're in that sympathetic nervous system activation all the time, I call system activation all the time, I call system activation all the time, I call it sympathetic overdrive. you're just it sympathetic overdrive. you're just it sympathetic overdrive. you're just shoving all those neurotransmitters and shoving all those neurotransmitters and shoving all those neurotransmitters and hormones out all the time. And that hormones out all the time. And that hormones out all the time. And that causes deterioration in immune system causes deterioration in immune system causes deterioration in immune system function, in hormone function, and in function, in hormone function, and in function, in hormone function, and in your mitochondria itself. So, to define your mitochondria itself. So, to define your mitochondria itself. So, to define mitochondria, which we can do now, yeah. mitochondria, which we can do now, yeah. mitochondria, which we can do now, yeah. Um the mitochondria are part of the cell Um the mitochondria are part of the cell Um the mitochondria are part of the cell that helps make energy, right? When I that helps make energy, right? When I that helps make energy, right? When I was in high school, my my daughter is in was in high school, my my daughter is in was in high school, my my daughter is in nth grade. She learned she's got the nth grade. She learned she's got the nth grade. She learned she's got the basic cell. She just learned she's like, basic cell. She just learned she's like, basic cell. She just learned she's like, "Dad, check out the basic cell. It's got "Dad, check out the basic cell. It's got "Dad, check out the basic cell. It's got a nucleus. It's got cytoplasm. It's got a nucleus. It's got cytoplasm. It's got a nucleus. It's got cytoplasm. It's got gogi bodies. And it's got this one gogi bodies. And it's got this one gogi bodies. And it's got this one little cool organel called the little cool organel called the little cool organel called the mitochondria." I'm like, "Huh? This is mitochondria." I'm like, "Huh? This is mitochondria." I'm like, "Huh? This is what I learned when I was probably that what I learned when I was probably that what I learned when I was probably that age too. You learn that the cell has one age too. You learn that the cell has one age too. You learn that the cell has one mitochondria. But that is far from the mitochondria. But that is far from the mitochondria. But that is far from the case, right? Thousands. case, right? Thousands. case, right? Thousands. >> Some cells in our body have thousands of >> Some cells in our body have thousands of >> Some cells in our body have thousands of mitochondria per cell. And some cells, mitochondria per cell. And some cells, mitochondria per cell. And some cells, actually there's one human cell that has actually there's one human cell that has actually there's one human cell that has zero, and that's the red blood cell. zero, and that's the red blood cell. zero, and that's the red blood cell. >> Yeah. The red blood, >> Yeah. The red blood, >> Yeah. The red blood, >> right? But most mitochondria per cell >> right? But most mitochondria per cell >> right? But most mitochondria per cell are in our reproductive organs. Eggs, are in our reproductive organs. Eggs, are in our reproductive organs. Eggs, oases, sperm are the number one. And oases, sperm are the number one. And oases, sperm are the number one. And number two, number two, number two, >> swim. They little energy to swim. >> swim. They little energy to swim. >> swim. They little energy to swim. >> Yeah. And the eggs have more though. >> Yeah. And the eggs have more though. >> Yeah. And the eggs have more though. Women have to, you know, create, make Women have to, you know, create, make Women have to, you know, create, make the baby, and so they have more. But the baby, and so they have more. But the baby, and so they have more. But then just behind that is your brain, then just behind that is your brain, then just behind that is your brain, your heart, your liver, your muscular your heart, your liver, your muscular your heart, your liver, your muscular skeletal tissue. So detox everybody is skeletal tissue. So detox everybody is skeletal tissue. So detox everybody is hugely energetically intensive. People hugely energetically intensive. People hugely energetically intensive. People don't realize that is like if you need don't realize that is like if you need don't realize that is like if you need if you're going to be able to detox you if you're going to be able to detox you if you're going to be able to detox you have to have a huge amount of have to have a huge amount of have to have a huge amount of mitochondrial energy. And so we have mitochondrial energy. And so we have mitochondrial energy. And so we have thousands of mitochondria in our brain thousands of mitochondria in our brain thousands of mitochondria in our brain for example as I mentioned. The problem for example as I mentioned. The problem for example as I mentioned. The problem is and the statistics are crazy. It's is and the statistics are crazy. It's is and the statistics are crazy. It's like 94% of us adults have some element like 94% of us adults have some element like 94% of us adults have some element of metabolic dysfunction, right? And if of metabolic dysfunction, right? And if of metabolic dysfunction, right? And if you have metabolic dysfunction, you also you have metabolic dysfunction, you also you have metabolic dysfunction, you also have mitochondrial dysfunction, which have mitochondrial dysfunction, which have mitochondrial dysfunction, which means you can't make energy effectively. means you can't make energy effectively. means you can't make energy effectively. Our cells are like gasoline powered Our cells are like gasoline powered Our cells are like gasoline powered cars, right? We make ATP as you know, we cars, right? We make ATP as you know, we cars, right? We make ATP as you know, we make also carbon dioxide, we make water, make also carbon dioxide, we make water, make also carbon dioxide, we make water, and we also make what are called and we also make what are called and we also make what are called reactive oxygen species. Free radicals. reactive oxygen species. Free radicals. reactive oxygen species. Free radicals. Yes. Exactly. And so we need those. But Yes. Exactly. And so we need those. But Yes. Exactly. And so we need those. But if we have too many or if we're if we have too many or if we're if we have too many or if we're stimulated for such a such a long time stimulated for such a such a long time stimulated for such a such a long time or a period of time like you're or a period of time like you're or a period of time like you're sympathetically overdriven, right, sympathetically overdriven, right, sympathetically overdriven, right, you're stimulating the mitochondria to you're stimulating the mitochondria to you're stimulating the mitochondria to make so much energy or trying to. And make so much energy or trying to. And make so much energy or trying to. And what happens over time is that the what happens over time is that the what happens over time is that the mitochondria can't keep up. They can't mitochondria can't keep up. They can't mitochondria can't keep up. They can't keep up with energy production. They keep up with energy production. They keep up with energy production. They can't keep it up with the detoxification can't keep it up with the detoxification can't keep it up with the detoxification required because you don't have enough required because you don't have enough required because you don't have enough antioxidants around. And then the antioxidants around. And then the antioxidants around. And then the mitochondria become under significant mitochondria become under significant mitochondria become under significant amounts of stress. amounts of stress. amounts of stress. >> And so you're in this place now where >> And so you're in this place now where >> And so you're in this place now where you have sympathetic overdrive, you have sympathetic overdrive, you have sympathetic overdrive, mitochondrial dysfunction in the mitochondrial dysfunction in the mitochondrial dysfunction in the majority of people. And it's a spectrum majority of people. And it's a spectrum majority of people. And it's a spectrum now, but all of these people, everybody, now, but all of these people, everybody, now, but all of these people, everybody, so many of us are on this sympathetic so many of us are on this sympathetic so many of us are on this sympathetic spiral as a result of that. spiral as a result of that. spiral as a result of that. >> And what's really interesting is the >> And what's really interesting is the >> And what's really interesting is the connection between the stress response, connection between the stress response, connection between the stress response, which we all can relate to. which we all can relate to. which we all can relate to. >> Yeah. >> Yeah. >> Yeah. >> And our mitochondrial function, which is >> And our mitochondrial function, which is >> And our mitochondrial function, which is >> which is basically something that, you >> which is basically something that, you >> which is basically something that, you know, most of us don't think about. And know, most of us don't think about. And know, most of us don't think about. And by the way, most doctors don't know by the way, most doctors don't know by the way, most doctors don't know >> much about that. We didn't we learned ma >> much about that. We didn't we learned ma >> much about that. We didn't we learned ma basically biochemistry in the first basically biochemistry in the first basically biochemistry in the first semester of medical school how to you semester of medical school how to you semester of medical school how to you know food and oxygen go through our know food and oxygen go through our know food and oxygen go through our little KB cycle mitochondria little KB cycle mitochondria little KB cycle mitochondria >> you you memorize all the intermediate >> you you memorize all the intermediate >> you you memorize all the intermediate >> and we memorize it for five minutes >> and we memorize it for five minutes >> and we memorize it for five minutes before the test and we forget about it before the test and we forget about it before the test and we forget about it but mitochondria are central to almost but mitochondria are central to almost but mitochondria are central to almost every single disease that we see in every single disease that we see in every single disease that we see in chronic illness whether it's dementia or chronic illness whether it's dementia or chronic illness whether it's dementia or cancer or heart disease or obesity or cancer or heart disease or obesity or cancer or heart disease or obesity or diabetes or all the all the diabetes or all the all the diabetes or all the all the neurodeenerative diseases it's just neurodeenerative diseases it's just neurodeenerative diseases it's just quite it's quite profoundly ly important quite it's quite profoundly ly important quite it's quite profoundly ly important and and you're right like if you if you and and you're right like if you if you and and you're right like if you if you are um in this stress response and then are um in this stress response and then are um in this stress response and then you're also exposed to all the stresses you're also exposed to all the stresses you're also exposed to all the stresses of being in the modern world with of being in the modern world with of being in the modern world with microlastics and pesticides and heavy microlastics and pesticides and heavy microlastics and pesticides and heavy metals and metals and metals and >> latent viruses, infections, long COVID, >> latent viruses, infections, long COVID, >> latent viruses, infections, long COVID, tick infections, mold exposure, tick infections, mold exposure, tick infections, mold exposure, >> insulin resistance, >> insulin resistance, >> insulin resistance, >> insulin like the whole thing. And then >> insulin like the whole thing. And then >> insulin like the whole thing. And then of course our our ultra sort of of course our our ultra sort of of course our our ultra sort of processed diet that I was getting to processed diet that I was getting to processed diet that I was getting to that that that >> you know our highly sugary processed >> you know our highly sugary processed >> you know our highly sugary processed diet. So, you know, we all are stressing diet. So, you know, we all are stressing diet. So, you know, we all are stressing our stress response because you you're our stress response because you you're our stress response because you you're by the way, eating crap makes your body by the way, eating crap makes your body by the way, eating crap makes your body stressed even if you don't stressed even if you don't stressed even if you don't psychologically feel stressed and also psychologically feel stressed and also psychologically feel stressed and also it stresses your mitochondria. So then it stresses your mitochondria. So then it stresses your mitochondria. So then you get all these insults. You talk you get all these insults. You talk you get all these insults. You talk about this sort of metabolic stress. about this sort of metabolic stress. about this sort of metabolic stress. Yeah. You know what what are like the Yeah. You know what what are like the Yeah. You know what what are like the main symptoms people are this main symptoms people are this main symptoms people are this sympathetic sp like how would people sympathetic sp like how would people sympathetic sp like how would people listening know I have this? So when it listening know I have this? So when it listening know I have this? So when it comes down to when the mitochondria are comes down to when the mitochondria are comes down to when the mitochondria are so stressed they shift over from being so stressed they shift over from being so stressed they shift over from being make being being able to make energy make being being able to make energy make being being able to make energy effectively instead of making energy effectively instead of making energy effectively instead of making energy like with oxygen they actually shift like with oxygen they actually shift like with oxygen they actually shift over into something called the gly the over into something called the gly the over into something called the gly the glycolytic state which is making less glycolytic state which is making less glycolytic state which is making less energy because they're trying to protect energy because they're trying to protect energy because they're trying to protect themselves from all the stress that's themselves from all the stress that's themselves from all the stress that's that they're on. And when that happens that they're on. And when that happens that they're on. And when that happens it's there's an overcompensation of the it's there's an overcompensation of the it's there's an overcompensation of the sympathetic nervous system. The sympathetic nervous system. The sympathetic nervous system. The sympathetic overdrive gets even higher sympathetic overdrive gets even higher sympathetic overdrive gets even higher because you physically feel worse. because you physically feel worse. because you physically feel worse. >> And these are the symptoms you're >> And these are the symptoms you're >> And these are the symptoms you're talking about. We're talking about talking about. We're talking about talking about. We're talking about feeling tired but wired. Feeling like feeling tired but wired. Feeling like feeling tired but wired. Feeling like you can't recover anymore from anything you can't recover anymore from anything you can't recover anymore from anything that was pretty small before. Something that was pretty small before. Something that was pretty small before. Something small now it takes you two or three small now it takes you two or three small now it takes you two or three days. Like you go to the gym, you don't days. Like you go to the gym, you don't days. Like you go to the gym, you don't feel like you really recover for two or feel like you really recover for two or feel like you really recover for two or three days. Or you go on an airplane, three days. Or you go on an airplane, three days. Or you go on an airplane, you don't recover for much longer. Or you don't recover for much longer. Or you don't recover for much longer. Or you have a bad night of sleep and you you have a bad night of sleep and you you have a bad night of sleep and you feel terrible the next day. Or your mood feel terrible the next day. Or your mood feel terrible the next day. Or your mood is all over the place. It used to be is all over the place. It used to be is all over the place. It used to be pretty stable throughout the day, pretty stable throughout the day, pretty stable throughout the day, barring going through parmenopause or barring going through parmenopause or barring going through parmenopause or something like that. It used to be something like that. It used to be something like that. It used to be stable and now it's all over the place. stable and now it's all over the place. stable and now it's all over the place. Um, you also can find that just overall Um, you also can find that just overall Um, you also can find that just overall your energy levels just kind of up and your energy levels just kind of up and your energy levels just kind of up and down throughout the day. Like you're down throughout the day. Like you're down throughout the day. Like you're relying on things like caffeine and relying on things like caffeine and relying on things like caffeine and stimulants to try to give you enough stimulants to try to give you enough stimulants to try to give you enough energy, give you enough brain function. energy, give you enough brain function. energy, give you enough brain function. And the challenge often times, and I And the challenge often times, and I And the challenge often times, and I have patients like this, it's like, doc, have patients like this, it's like, doc, have patients like this, it's like, doc, I just need to feel better. I need more I just need to feel better. I need more I just need to feel better. I need more stimulation. I need more energy. And stimulation. I need more energy. And stimulation. I need more energy. And often times it's not about giving them often times it's not about giving them often times it's not about giving them more energy. It's actually about calming more energy. It's actually about calming more energy. It's actually about calming down the whole system, this whole loop, down the whole system, this whole loop, down the whole system, this whole loop, this spiral, and then allowing them to this spiral, and then allowing them to this spiral, and then allowing them to get back to making energy more get back to making energy more get back to making energy more effectively. And so there's a spectrum effectively. And so there's a spectrum effectively. And so there's a spectrum here, Mark, and you and I know this. We here, Mark, and you and I know this. We here, Mark, and you and I know this. We have people that are super, you know, have people that are super, you know, have people that are super, you know, complex and they've been sick for a long complex and they've been sick for a long complex and they've been sick for a long time and have, you know, very time and have, you know, very time and have, you know, very significant mitochondrial issues. And significant mitochondrial issues. And significant mitochondrial issues. And then you have people that are on the then you have people that are on the then you have people that are on the other side of the spectrum where they other side of the spectrum where they other side of the spectrum where they just don't feel very good anymore. Like just don't feel very good anymore. Like just don't feel very good anymore. Like they're just not waking up feeling like they're just not waking up feeling like they're just not waking up feeling like they have energy. Their energy is waning they have energy. Their energy is waning they have energy. Their energy is waning throughout the day. Their recovery just throughout the day. Their recovery just throughout the day. Their recovery just not as good. And like often times with not as good. And like often times with not as good. And like often times with those people that it's something often those people that it's something often those people that it's something often happens where they feel like they just happens where they feel like they just happens where they feel like they just fall off a cliff. Yeah. It's like that fall off a cliff. Yeah. It's like that fall off a cliff. Yeah. It's like that extra little stress that just did it and extra little stress that just did it and extra little stress that just did it and then all of a sudden the things go down. then all of a sudden the things go down. then all of a sudden the things go down. >> Yeah. They they kind of manage along as >> Yeah. They they kind of manage along as >> Yeah. They they kind of manage along as they crash. Yeah. they crash. Yeah. they crash. Yeah. >> Yeah. >> Yeah. >> Yeah. >> And it's common. A lot of people have >> And it's common. A lot of people have >> And it's common. A lot of people have this and this and this and it it and if you looked at it as it it and if you looked at it as it it and if you looked at it as spectrum, you know, some most of us are spectrum, you know, some most of us are spectrum, you know, some most of us are somewhere in that spectrum. somewhere in that spectrum. somewhere in that spectrum. >> Yeah. >> Yeah. >> Yeah. >> I want to share something personal about >> I want to share something personal about >> I want to share something personal about my own health journey. Now, a while my own health journey. Now, a while my own health journey. Now, a while back, I went through a period where I back, I went through a period where I back, I went through a period where I was recovering physically and working was recovering physically and working was recovering physically and working hard to rebuild my strength. I was doing hard to rebuild my strength. I was doing hard to rebuild my strength. I was doing all the right things, eating well, all the right things, eating well, all the right things, eating well, exercising. I was focusing on sleep and exercising. I was focusing on sleep and exercising. I was focusing on sleep and recovery. But I started looking more recovery. But I started looking more recovery. But I started looking more closely at how the body actually uses closely at how the body actually uses closely at how the body actually uses protein as we age. And here's the thing, protein as we age. And here's the thing, protein as we age. And here's the thing, our bodies don't always utilize protein our bodies don't always utilize protein our bodies don't always utilize protein as efficiently as we get older. So even as efficiently as we get older. So even as efficiently as we get older. So even when you're eating well, you may not when you're eating well, you may not when you're eating well, you may not always be getting the essential amino always be getting the essential amino always be getting the essential amino acids your body needs to support muscle acids your body needs to support muscle acids your body needs to support muscle repair and recovery. And that's when I repair and recovery. And that's when I repair and recovery. And that's when I started using perfect aminos. Now, I started using perfect aminos. Now, I started using perfect aminos. Now, I want to be clear, this isn't about want to be clear, this isn't about want to be clear, this isn't about replacing whole food protein. I'm a huge replacing whole food protein. I'm a huge replacing whole food protein. I'm a huge believer in getting high quality protein believer in getting high quality protein believer in getting high quality protein from real food, but perfect amino can be from real food, but perfect amino can be from real food, but perfect amino can be a very convenient way to complement your a very convenient way to complement your a very convenient way to complement your diet and to help make sure you're diet and to help make sure you're diet and to help make sure you're getting the essential amino acids your getting the essential amino acids your getting the essential amino acids your body relies on. The essential amino body relies on. The essential amino body relies on. The essential amino acids are nine amino acids your body acids are nine amino acids your body acids are nine amino acids your body cannot make on its own. So, you have to cannot make on its own. So, you have to cannot make on its own. 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That's ko rr us.com/phere That's ko rr us.com/phere That's ko rr us.com/phere and use the code himmanphere 15. and use the code himmanphere 15. and use the code himmanphere 15. >> Yeah. >> Yeah. >> Yeah. >> So, so this you talk about this feedback >> So, so this you talk about this feedback >> So, so this you talk about this feedback loop between the nervous system and the loop between the nervous system and the loop between the nervous system and the mitochondria because I think it's it's a mitochondria because I think it's it's a mitochondria because I think it's it's a it's a little bit hard conceptually for it's a little bit hard conceptually for it's a little bit hard conceptually for people to understand well how does that people to understand well how does that people to understand well how does that work? You got your nervous system. work? You got your nervous system. work? You got your nervous system. >> Yeah. Your sympathetic parasympathetic >> Yeah. Your sympathetic parasympathetic >> Yeah. Your sympathetic parasympathetic and your stress response, your and your stress response, your and your stress response, your relaxation response. But relaxation response. But relaxation response. But >> how does that relate to your >> how does that relate to your >> how does that relate to your mitochondria and your energy system? And mitochondria and your energy system? And mitochondria and your energy system? And how what is that connection and loop how what is that connection and loop how what is that connection and loop feedback loop? feedback loop? feedback loop? >> One of the main hormones that's being >> One of the main hormones that's being >> One of the main hormones that's being vilified right now is cortisol. Cortisol vilified right now is cortisol. Cortisol vilified right now is cortisol. Cortisol is your stress steroid hormone. As you is your stress steroid hormone. As you is your stress steroid hormone. As you know, when you're under fight or flight, know, when you're under fight or flight, know, when you're under fight or flight, when you're in sympathetic overdrive all when you're in sympathetic overdrive all when you're in sympathetic overdrive all the time, you're pumping out cortisol the time, you're pumping out cortisol the time, you're pumping out cortisol all the time. We're supposed to have all the time. We're supposed to have all the time. We're supposed to have cortisol rise when we wake up in the cortisol rise when we wake up in the cortisol rise when we wake up in the morning. It helps us wake up from being morning. It helps us wake up from being morning. It helps us wake up from being asleep and then it's supposed to slowly asleep and then it's supposed to slowly asleep and then it's supposed to slowly go down throughout the day. Yeah. go down throughout the day. Yeah. go down throughout the day. Yeah. >> The challenge is that most people do not >> The challenge is that most people do not >> The challenge is that most people do not have that pattern anymore. And what have that pattern anymore. And what have that pattern anymore. And what cortisol does is it stimulates the cortisol does is it stimulates the cortisol does is it stimulates the production of it's a steroid hormone. It production of it's a steroid hormone. It production of it's a steroid hormone. It also stimulates and initiates the also stimulates and initiates the also stimulates and initiates the norepinephrine and epinephrine. So norepinephrine and epinephrine. So norepinephrine and epinephrine. So norepinephrine, nor adrenaline and norepinephrine, nor adrenaline and norepinephrine, nor adrenaline and adrenaline in the system too. And what adrenaline in the system too. And what adrenaline in the system too. And what happens when you have a lot of cortisol happens when you have a lot of cortisol happens when you have a lot of cortisol around a lot of those neurotransmitters around a lot of those neurotransmitters around a lot of those neurotransmitters is that you are just telling your is that you are just telling your is that you are just telling your mitochondria that you're under stress. mitochondria that you're under stress. mitochondria that you're under stress. You need energy now. And as a result of You need energy now. And as a result of You need energy now. And as a result of that, it is going to your mitochondria that, it is going to your mitochondria that, it is going to your mitochondria and saying mitochondria, you need to and saying mitochondria, you need to and saying mitochondria, you need to make more energy now because you're make more energy now because you're make more energy now because you're under a lot of stress. this cortisol is under a lot of stress. this cortisol is under a lot of stress. this cortisol is high and as a result of that you're high and as a result of that you're high and as a result of that you're getting the mitochondria that are like getting the mitochondria that are like getting the mitochondria that are like >> we can't keep up. There's too much >> we can't keep up. There's too much >> we can't keep up. There's too much energy requirements that you're giving energy requirements that you're giving energy requirements that you're giving us. And so that's why it flips over into us. And so that's why it flips over into us. And so that's why it flips over into this something called the cell danger this something called the cell danger this something called the cell danger response which I know you know about response which I know you know about response which I know you know about which is when the cell says we have to which is when the cell says we have to which is when the cell says we have to protect ourselves. And the mitochondria protect ourselves. And the mitochondria protect ourselves. And the mitochondria says we're sensing too much stress. We says we're sensing too much stress. We says we're sensing too much stress. We can't actually keep up. And so what it can't actually keep up. And so what it can't actually keep up. And so what it does is it tries to protect itself. But does is it tries to protect itself. But does is it tries to protect itself. But then when that happens you start making then when that happens you start making then when that happens you start making less energy. And when you start making less energy. And when you start making less energy. And when you start making less energy, you start feeling like less energy, you start feeling like less energy, you start feeling like you're not able to compensate. You're you're not able to compensate. You're you're not able to compensate. You're not actually able to show up the way not actually able to show up the way not actually able to show up the way you're tired. You're tired. This is the you're tired. You're tired. This is the you're tired. You're tired. This is the tired but wired kind of feeling. tired but wired kind of feeling. tired but wired kind of feeling. >> The ability of the mitochondria to kind >> The ability of the mitochondria to kind >> The ability of the mitochondria to kind of like register this danger is of like register this danger is of like register this danger is interesting. And you know, you talk interesting. And you know, you talk interesting. And you know, you talk about this this new concept, this cell about this this new concept, this cell about this this new concept, this cell danger response. But if you actually danger response. But if you actually danger response. But if you actually look in the medical literature, it's look in the medical literature, it's look in the medical literature, it's there. There's a lot of scientific there. There's a lot of scientific there. There's a lot of scientific papers about this. It's not just some papers about this. It's not just some papers about this. It's not just some >> woo woo thing. It sounds kind of a >> woo woo thing. It sounds kind of a >> woo woo thing. It sounds kind of a little crazy, but you actually look at little crazy, but you actually look at little crazy, but you actually look at it and I think most physicians don't it and I think most physicians don't it and I think most physicians don't understand what it is. understand what it is. understand what it is. >> No. >> No. >> No. >> So, so you know it's what I'm just >> So, so you know it's what I'm just >> So, so you know it's what I'm just hearing as you say is when you have hearing as you say is when you have hearing as you say is when you have chronic stress either from the top down chronic stress either from the top down chronic stress either from the top down or bottom up from, you know, your brain or bottom up from, you know, your brain or bottom up from, you know, your brain or from Yeah. or from Yeah. or from Yeah. >> you know, the toxin crap and we're >> you know, the toxin crap and we're >> you know, the toxin crap and we're all exposed to, all exposed to, all exposed to, >> it stresses your mitochondria and then >> it stresses your mitochondria and then >> it stresses your mitochondria and then it flips into this cycle, this cell it flips into this cycle, this cell it flips into this cycle, this cell danger response, which is that the same danger response, which is that the same danger response, which is that the same thing as a sympathetic spiral of doom? thing as a sympathetic spiral of doom? thing as a sympathetic spiral of doom? >> That's part of it, right? Because you >> That's part of it, right? Because you >> That's part of it, right? Because you when you're in that sympathetic spiral, when you're in that sympathetic spiral, when you're in that sympathetic spiral, you're almost always flipping over into you're almost always flipping over into you're almost always flipping over into that cell danger response. that cell danger response. that cell danger response. >> And so unpack what is this cell danger >> And so unpack what is this cell danger >> And so unpack what is this cell danger response? response? response? >> The cell danger response is a natural >> The cell danger response is a natural >> The cell danger response is a natural respon response that the that the cells respon response that the that the cells respon response that the that the cells do when they're under stress. There's do when they're under stress. There's do when they're under stress. There's multiple stages of the CDR. Um and multiple stages of the CDR. Um and multiple stages of the CDR. Um and there's a very there's a very there's a very >> CDR cell danger >> CDR cell danger >> CDR cell danger >> cell danger response. Yes. Sorry. Um and >> cell danger response. Yes. Sorry. Um and >> cell danger response. Yes. Sorry. Um and as a result of having this pattern, we as a result of having this pattern, we as a result of having this pattern, we have a way of either have a way of either have a way of either going anabolic or catabolic, which means going anabolic or catabolic, which means going anabolic or catabolic, which means that we can either build up or break that we can either build up or break that we can either build up or break down in the system. And what the CDR down in the system. And what the CDR down in the system. And what the CDR does when the cell danger response is does when the cell danger response is does when the cell danger response is active, we get into more of a catabolic active, we get into more of a catabolic active, we get into more of a catabolic state. We start breaking down parts of state. We start breaking down parts of state. We start breaking down parts of our body to try to protect it. Um, where our body to try to protect it. Um, where our body to try to protect it. Um, where in the anabolic state is really when in the anabolic state is really when in the anabolic state is really when we're building up and getting stronger. we're building up and getting stronger. we're building up and getting stronger. That's when you're in a safe space, That's when you're in a safe space, That's when you're in a safe space, right? When you're in safe spaces, right? When you're in safe spaces, right? When you're in safe spaces, you're parasympathetic. I call it the you're parasympathetic. I call it the you're parasympathetic. I call it the parasympathetic edge really. And and and parasympathetic edge really. And and and parasympathetic edge really. And and and we can talk about that, but the idea is we can talk about that, but the idea is we can talk about that, but the idea is when you're in the parasympathetic mode, when you're in the parasympathetic mode, when you're in the parasympathetic mode, you're resting, digesting. You can turn you're resting, digesting. You can turn you're resting, digesting. You can turn off the cell danger response, but you off the cell danger response, but you off the cell danger response, but you can't turn it off if you're always in can't turn it off if you're always in can't turn it off if you're always in stress mode. And the cell danger stress mode. And the cell danger stress mode. And the cell danger response is basically protecting you response is basically protecting you response is basically protecting you from stress. It's protecting you so that from stress. It's protecting you so that from stress. It's protecting you so that you can survive. It's a survival mode. you can survive. It's a survival mode. you can survive. It's a survival mode. It's also also activated in the short It's also also activated in the short It's also also activated in the short term when you have acute stress, when term when you have acute stress, when term when you have acute stress, when you have acute infection, you have acute you have acute infection, you have acute you have acute infection, you have acute um additional stress outside, external um additional stress outside, external um additional stress outside, external stress, but it's supposed to turn itself stress, but it's supposed to turn itself stress, but it's supposed to turn itself off. But it can't turn itself off if it off. But it can't turn itself off if it off. But it can't turn itself off if it doesn't have that anabolic doesn't have that anabolic doesn't have that anabolic parasympathetic activation. And that's parasympathetic activation. And that's parasympathetic activation. And that's the challenge. And and and in addition the challenge. And and and in addition the challenge. And and and in addition to that, what happens over time is that to that, what happens over time is that to that, what happens over time is that you deplete a lot of the intermediates, you deplete a lot of the intermediates, you deplete a lot of the intermediates, a lot of the vitamins, minerals, a lot of the vitamins, minerals, a lot of the vitamins, minerals, nutrients, and co-actors that are nutrients, and co-actors that are nutrients, and co-actors that are responsible for shifting you out of the responsible for shifting you out of the responsible for shifting you out of the cell danger response. cell danger response. cell danger response. >> So just the very fact of trying to >> So just the very fact of trying to >> So just the very fact of trying to manage the danger. you're using a lot of manage the danger. you're using a lot of manage the danger. you're using a lot of nutrients, tons of it, and you deplete nutrients, tons of it, and you deplete nutrients, tons of it, and you deplete your nutrients and then you end up in your nutrients and then you end up in your nutrients and then you end up in this vicious cycle where you need the this vicious cycle where you need the this vicious cycle where you need the nutrients to fix the problem, but you nutrients to fix the problem, but you nutrients to fix the problem, but you don't have the nutrients and it depletes don't have the nutrients and it depletes don't have the nutrients and it depletes them them them >> and you're still in the stress mode and >> and you're still in the stress mode and >> and you're still in the stress mode and you're still right. So, the the the you're still right. So, the the the you're still right. So, the the the major question is, well, how do you major question is, well, how do you major question is, well, how do you approach it? How do you work on approach it? How do you work on approach it? How do you work on optimizing somebody's capacity and optimizing somebody's capacity and optimizing somebody's capacity and increasing their reserve, getting them increasing their reserve, getting them increasing their reserve, getting them out of the sympathetic, but also out of the sympathetic, but also out of the sympathetic, but also supporting their capacity to flip out of supporting their capacity to flip out of supporting their capacity to flip out of that cell danger response and support that cell danger response and support that cell danger response and support mitochondrial function? mitochondrial function? mitochondrial function? >> Well, that's an important question. I >> Well, that's an important question. I >> Well, that's an important question. I want to get into the practical aspects want to get into the practical aspects want to get into the practical aspects of how do people of how do people of how do people >> end the sympathetic spell and how do >> end the sympathetic spell and how do >> end the sympathetic spell and how do they they they >> stop the cell danger response but before >> stop the cell danger response but before >> stop the cell danger response but before we get to that we get to that we get to that >> I want to kind of unpack a little bit >> I want to kind of unpack a little bit >> I want to kind of unpack a little bit about your top down bottom up idea here about your top down bottom up idea here about your top down bottom up idea here because it's important because it's important because it's important >> because you know you can enter into this >> because you know you can enter into this >> because you know you can enter into this sympathetic spy sympathetic spy sympathetic spy state for sure from trauma or from your state for sure from trauma or from your state for sure from trauma or from your biological state from things you're biological state from things you're biological state from things you're exposed to in the environment that you exposed to in the environment that you exposed to in the environment that you may have control over or your diet which may have control over or your diet which may have control over or your diet which you do have control over. Right. So can you do have control over. Right. So can you do have control over. Right. So can you kind of walk us through the top down you kind of walk us through the top down you kind of walk us through the top down bottom up explanation and where the bottom up explanation and where the bottom up explanation and where the where where are the contributors to the where where are the contributors to the where where are the contributors to the sympathetic spell of doom and cell sympathetic spell of doom and cell sympathetic spell of doom and cell danger response. So I think if we danger response. So I think if we danger response. So I think if we understand what those are, we can start understand what those are, we can start understand what those are, we can start to think about how we might approach to think about how we might approach to think about how we might approach them. them. them. >> The top down part, let's talk about that >> The top down part, let's talk about that >> The top down part, let's talk about that first. The top down part is how are we first. The top down part is how are we first. The top down part is how are we stressed? What is causing our stressed? What is causing our stressed? What is causing our sympathetic activation? And the amount sympathetic activation? And the amount sympathetic activation? And the amount of things that can be doing this is of things that can be doing this is of things that can be doing this is unlimited in this. We can talk about it unlimited in this. We can talk about it unlimited in this. We can talk about it from social media to politics to what's from social media to politics to what's from social media to politics to what's going around in the world right now with going around in the world right now with going around in the world right now with wars and things like that. Two things wars and things like that. Two things wars and things like that. Two things >> distress in the world right now. >> distress in the world right now. >> distress in the world right now. >> I mean a little. I mean a little. I mean >> I mean a little. I mean a little. I mean >> I mean a little. I mean a little. I mean it's not going away. it's not going away. it's not going away. >> Yeah. >> Yeah. >> Yeah. >> And we are wired as humans to do two >> And we are wired as humans to do two >> And we are wired as humans to do two things. Survive and reproduce. That's things. Survive and reproduce. That's things. Survive and reproduce. That's it. That's what we are wired to do it. That's what we are wired to do it. That's what we are wired to do because that's what the species because that's what the species because that's what the species requires. And so as a result of that, requires. And so as a result of that, requires. And so as a result of that, what do our news media? What does our what do our news media? What does our what do our news media? What does our social media do? It wires you, it's social media do? It wires you, it's social media do? It wires you, it's wired or it's it's created to fit into wired or it's it's created to fit into wired or it's it's created to fit into that those two patterns, survival and that those two patterns, survival and that those two patterns, survival and reproduction, mostly survival. So fear, reproduction, mostly survival. So fear, reproduction, mostly survival. So fear, right? Fear is the biggest one. And so right? Fear is the biggest one. And so right? Fear is the biggest one. And so there's tons of things that are coming there's tons of things that are coming there's tons of things that are coming outside of us all the time that are outside of us all the time that are outside of us all the time that are trying to instill fear in us. It could trying to instill fear in us. It could trying to instill fear in us. It could be everything from the things I be everything from the things I be everything from the things I mentioned. It could be within your own mentioned. It could be within your own mentioned. It could be within your own home, right? If it's a relationship, home, right? If it's a relationship, home, right? If it's a relationship, that isn't great. If it's a job, that's that isn't great. If it's a job, that's that isn't great. If it's a job, that's too hard. If you're not getting enough too hard. If you're not getting enough too hard. If you're not getting enough sleep, that's a huge one because if sleep, that's a huge one because if sleep, that's a huge one because if you're not getting enough sleep, you're you're not getting enough sleep, you're you're not getting enough sleep, you're not going to be able to regulate your not going to be able to regulate your not going to be able to regulate your nervous system either. And so, that's nervous system either. And so, that's nervous system either. And so, that's these that what I call the topdown these that what I call the topdown these that what I call the topdown aspects. And I could fill in aspects. And I could fill in aspects. And I could fill in >> all the psychological it can be your >> all the psychological it can be your >> all the psychological it can be your childhood trauma. childhood trauma. childhood trauma. >> This could and I had I mean, you've had >> This could and I had I mean, you've had >> This could and I had I mean, you've had patients like this too that you know, patients like this too that you know, patients like this too that you know, they were abused as a child and they they were abused as a child and they they were abused as a child and they never feel safe in their own body. never feel safe in their own body. never feel safe in their own body. There's no way they can ever heal. There's no way they can ever heal. There's no way they can ever heal. there's no way they can ever really there's no way they can ever really there's no way they can ever really fully truly be their best self because fully truly be their best self because fully truly be their best self because they're always in this locked in they're always in this locked in they're always in this locked in sympathetic. sympathetic. sympathetic. >> But there's ways for people to come out >> But there's ways for people to come out >> But there's ways for people to come out of that of that of that >> 100%. Yeah, we'll talk about that. And >> 100%. Yeah, we'll talk about that. And >> 100%. Yeah, we'll talk about that. And then that's exactly what this is all then that's exactly what this is all then that's exactly what this is all about. It's about understanding the about. It's about understanding the about. It's about understanding the pattern and then seeing how to break. pattern and then seeing how to break. pattern and then seeing how to break. >> So that's the top down. That's the top >> So that's the top down. That's the top >> So that's the top down. That's the top down and the bottom up is down and the bottom up is down and the bottom up is >> the bottom bottom up is really you did a >> the bottom bottom up is really you did a >> the bottom bottom up is really you did a great job earlier when we were talking great job earlier when we were talking great job earlier when we were talking about direct mitochondrial stress. You about direct mitochondrial stress. You about direct mitochondrial stress. You know, things like infections and know, things like infections and know, things like infections and >> they're very sensitive. Mitochondria >> they're very sensitive. Mitochondria >> they're very sensitive. Mitochondria very sensitive. Everything affects them. very sensitive. Everything affects them. very sensitive. Everything affects them. They do. They do. It's I mean they're a They do. They do. It's I mean they're a They do. They do. It's I mean they're a sensitive organel. There's a lot of sensitive organel. There's a lot of sensitive organel. There's a lot of them. There's quadrillions of them in them. There's quadrillions of them in them. There's quadrillions of them in our bodies. Huge amounts of them. our bodies. Huge amounts of them. our bodies. Huge amounts of them. >> That's a big number. >> That's a big number. >> That's a big number. >> I can't count that. I >> I can't count that. I >> I can't count that. I >> I can't either, but it's a quad. I know >> I can't either, but it's a quad. I know >> I can't either, but it's a quad. I know that. I think after that I can't that. I think after that I can't that. I think after that I can't remember. It's like I don't it's quint remember. It's like I don't it's quint remember. It's like I don't it's quint after that I think. But it's after after that I think. But it's after after that I think. But it's after trillions is quadrillions everybody trillions is quadrillions everybody trillions is quadrillions everybody that's listened. Okay. And so it's a lot that's listened. Okay. And so it's a lot that's listened. Okay. And so it's a lot of mitochondria. of mitochondria. of mitochondria. >> And so we need a huge amount of energy. >> And so we need a huge amount of energy. >> And so we need a huge amount of energy. In fact the we need to make about 150 In fact the we need to make about 150 In fact the we need to make about 150 pounds of it every single day of ATP to pounds of it every single day of ATP to pounds of it every single day of ATP to maintain our energy capacity. And as I maintain our energy capacity. And as I maintain our energy capacity. And as I mentioned, 94% of us can't do this on a mentioned, 94% of us can't do this on a mentioned, 94% of us can't do this on a regular basis. And that's because of the regular basis. And that's because of the regular basis. And that's because of the things you mentioned. You talked about things you mentioned. You talked about things you mentioned. You talked about insulin resistance and toxins in our insulin resistance and toxins in our insulin resistance and toxins in our environment. Um, medications that we environment. Um, medications that we environment. Um, medications that we take on a regular basis that actually take on a regular basis that actually take on a regular basis that actually have a dysfunctional impetus or actually have a dysfunctional impetus or actually have a dysfunctional impetus or actually make our our mitochondria make do worse. make our our mitochondria make do worse. make our our mitochondria make do worse. Things like metformin, even things like Things like metformin, even things like Things like metformin, even things like birth control pills even because they birth control pills even because they birth control pills even because they deplete nutrients that help with deplete nutrients that help with deplete nutrients that help with mitochondrial function. Not to say mitochondrial function. Not to say mitochondrial function. Not to say people should get off off their people should get off off their people should get off off their medications, but you know, but even medications, but you know, but even medications, but you know, but even proton pump inhibitors, which are proton pump inhibitors, which are proton pump inhibitors, which are >> acid blockers are a big one. That's the >> acid blockers are a big one. That's the >> acid blockers are a big one. That's the third leading cause of of of use of third leading cause of of of use of third leading cause of of of use of drugs and which is acid blockers from drugs and which is acid blockers from drugs and which is acid blockers from people eating a crappy diet. people eating a crappy diet. people eating a crappy diet. >> Yeah. But statins too. Statins also have >> Yeah. But statins too. Statins also have >> Yeah. But statins too. Statins also have significant significant significant >> impact and that's the number one class >> impact and that's the number one class >> impact and that's the number one class of drugs. So the number one and three of drugs. So the number one and three of drugs. So the number one and three class of drugs is causing mitochondrial. class of drugs is causing mitochondrial. class of drugs is causing mitochondrial. >> Statins and they have effect on on both >> Statins and they have effect on on both >> Statins and they have effect on on both complex one and complex 2 which are the complex one and complex 2 which are the complex one and complex 2 which are the two first proteins in the mitochondria two first proteins in the mitochondria two first proteins in the mitochondria that help you make energy. Now that help you make energy. Now that help you make energy. Now pesticides do it, infections do it. we pesticides do it, infections do it. we pesticides do it, infections do it. we talked about it. Um, and then and then talked about it. Um, and then and then talked about it. Um, and then and then of course the sympathetic activation of course the sympathetic activation of course the sympathetic activation which can be overarching to everything which can be overarching to everything which can be overarching to everything but on its own can cause mitochondrial but on its own can cause mitochondrial but on its own can cause mitochondrial stress. And I think that the way I kind stress. And I think that the way I kind stress. And I think that the way I kind of picture this and I talk about it with of picture this and I talk about it with of picture this and I talk about it with my patients is that you and I were my patients is that you and I were my patients is that you and I were talking. It's not just one thing. You talking. It's not just one thing. You talking. It's not just one thing. You know, it's often a combination and know, it's often a combination and know, it's often a combination and you're going you're riding you're going you're riding you're going you're riding >> combo package. >> combo package. >> combo package. >> Yeah, of course. you know, it's the >> Yeah, of course. you know, it's the >> Yeah, of course. you know, it's the bundle and like you're riding along, bundle and like you're riding along, bundle and like you're riding along, you're doing okay until you hit around, you're doing okay until you hit around, you're doing okay until you hit around, for most people, though it's getting for most people, though it's getting for most people, though it's getting worse now, like around like your mid30s, worse now, like around like your mid30s, worse now, like around like your mid30s, late 30s, like early 40s, and then late 30s, like early 40s, and then late 30s, like early 40s, and then things start going a little, you know, things start going a little, you know, things start going a little, you know, pear-shaped, as they say in Ireland, one pear-shaped, as they say in Ireland, one pear-shaped, as they say in Ireland, one of my favorite expressions. And they're of my favorite expressions. And they're of my favorite expressions. And they're like, "Yeah, a little pear-shaped." And like, "Yeah, a little pear-shaped." And like, "Yeah, a little pear-shaped." And things start to go like, "Why am I not things start to go like, "Why am I not things start to go like, "Why am I not recovering as well? Why do I need more recovering as well? Why do I need more recovering as well? Why do I need more sleep?" Or, "Why don't I feel as rested sleep?" Or, "Why don't I feel as rested sleep?" Or, "Why don't I feel as rested when I wake up in the morning?" or why when I wake up in the morning?" or why when I wake up in the morning?" or why does when my son comes in in the when does when my son comes in in the when does when my son comes in in the when she when he gets home at school at 4:00 she when he gets home at school at 4:00 she when he gets home at school at 4:00 and he says like hi dad I go what do you and he says like hi dad I go what do you and he says like hi dad I go what do you want you know I start like what's going want you know I start like what's going want you know I start like what's going on there you know and so you start on there you know and so you start on there you know and so you start noticing these things but as you said noticing these things but as you said noticing these things but as you said Mark it's happening at earlier and Mark it's happening at earlier and Mark it's happening at earlier and earlier ages because of just the amount earlier ages because of just the amount earlier ages because of just the amount of toxic exposure that people have on a of toxic exposure that people have on a of toxic exposure that people have on a regular basis which is crazy regular basis which is crazy regular basis which is crazy >> yeah is a lot it's a lot and you know >> yeah is a lot it's a lot and you know >> yeah is a lot it's a lot and you know the truth is we have a lot of the truth is we have a lot of the truth is we have a lot of mitochondria but they're fragile mitochondria but they're fragile mitochondria but they're fragile >> and they're very sensitive to any ins >> and they're very sensitive to any ins >> and they're very sensitive to any ins salt even like disturbances in your salt even like disturbances in your salt even like disturbances in your microbiome microbiome microbiome >> for sure >> for sure >> for sure >> and the bacteria in your gut can cause >> and the bacteria in your gut can cause >> and the bacteria in your gut can cause harm. harm. harm. >> Yeah. >> Yeah. >> Yeah. >> You know the microbiome mitochondrial >> You know the microbiome mitochondrial >> You know the microbiome mitochondrial connection people don't even think connection people don't even think connection people don't even think about. about. about. >> Yeah. The inter kingdom cross talk stuff >> Yeah. The inter kingdom cross talk stuff >> Yeah. The inter kingdom cross talk stuff is so cool. is so cool. is so cool. >> Very impressive. Yeah. >> Very impressive. Yeah. >> Very impressive. Yeah. >> And you know you mentioned quickly >> And you know you mentioned quickly >> And you know you mentioned quickly metformin. I think I want to just metformin. I think I want to just metformin. I think I want to just quickly double click on that. This is a quickly double click on that. This is a quickly double click on that. This is a drug that's widely been used for drug that's widely been used for drug that's widely been used for diabetes. I've used it for years in my diabetes. I've used it for years in my diabetes. I've used it for years in my practice and it can be a good drug for practice and it can be a good drug for practice and it can be a good drug for diabetes but it but it does have a weird diabetes but it but it does have a weird diabetes but it but it does have a weird side effect which is it inhibits side effect which is it inhibits side effect which is it inhibits mitochondrial complex one. And this is a mitochondrial complex one. And this is a mitochondrial complex one. And this is a like one of the first steps in producing like one of the first steps in producing like one of the first steps in producing energy from food and oxygen. energy from food and oxygen. energy from food and oxygen. >> And and one of the studies that most >> And and one of the studies that most >> And and one of the studies that most concerned me was they did a randomized concerned me was they did a randomized concerned me was they did a randomized control trial where they did progressive control trial where they did progressive control trial where they did progressive resistance training meaning strength resistance training meaning strength resistance training meaning strength training training training >> in two groups. One taking metformin and >> in two groups. One taking metformin and >> in two groups. One taking metformin and one not taking metformin. And the one one not taking metformin. And the one one not taking metformin. And the one taking metformin didn't have any muscle taking metformin didn't have any muscle taking metformin didn't have any muscle gains and it inhibited muscle growth. gains and it inhibited muscle growth. gains and it inhibited muscle growth. Yep. Yep. Yep. >> And that concerns me. So it's being used >> And that concerns me. So it's being used >> And that concerns me. So it's being used a lot for longevity and aging. I I feel a lot for longevity and aging. I I feel a lot for longevity and aging. I I feel strongly that it's not something people strongly that it's not something people strongly that it's not something people should use for that. I think in certain should use for that. I think in certain should use for that. I think in certain cases in certain patients it can be an cases in certain patients it can be an cases in certain patients it can be an adjunctive therapy and yeah is a adjunctive therapy and yeah is a adjunctive therapy and yeah is a transition to get off of drugs because transition to get off of drugs because transition to get off of drugs because you can reverse all of it with lifestyle you can reverse all of it with lifestyle you can reverse all of it with lifestyle but like yeah I just I think it's but like yeah I just I think it's but like yeah I just I think it's important. So so you've got you've got important. So so you've got you've got important. So so you've got you've got all this top down bottom up stuff. It all this top down bottom up stuff. It all this top down bottom up stuff. It even gets more interesting than that even gets more interesting than that even gets more interesting than that because a lot of new research and we've because a lot of new research and we've because a lot of new research and we've had Chris Pomero and others talking had Chris Pomero and others talking had Chris Pomero and others talking about the mitochondrial role in mental about the mitochondrial role in mental about the mitochondrial role in mental health. health. health. >> Oh yeah. So, it's not just that you lose >> Oh yeah. So, it's not just that you lose >> Oh yeah. So, it's not just that you lose energy and you're tired from the stress. energy and you're tired from the stress. energy and you're tired from the stress. Your your mitochondria play a big role Your your mitochondria play a big role Your your mitochondria play a big role in disregulating your mood, right, in disregulating your mood, right, in disregulating your mood, right, >> and your brain function. So, talk about >> and your brain function. So, talk about >> and your brain function. So, talk about that. that. that. >> Yeah, that's a big piece of I'm glad >> Yeah, that's a big piece of I'm glad >> Yeah, that's a big piece of I'm glad that you had Chris on. I think it's that you had Chris on. I think it's that you had Chris on. I think it's there. His work is so great looking at there. His work is so great looking at there. His work is so great looking at metabolic dysfunction and the reversal metabolic dysfunction and the reversal metabolic dysfunction and the reversal using the ketogenic diet, for example. using the ketogenic diet, for example. using the ketogenic diet, for example. And that's a big symptom of what we just And that's a big symptom of what we just And that's a big symptom of what we just described here that described here that described here that >> by talking about metabolic dysfunction, >> by talking about metabolic dysfunction, >> by talking about metabolic dysfunction, it's kind of confusing term. metabolic it's kind of confusing term. metabolic it's kind of confusing term. metabolic dysfunction in this context means dysfunction in this context means dysfunction in this context means >> how we turn food and oxygen into energy >> how we turn food and oxygen into energy >> how we turn food and oxygen into energy in the mitochondria that's our in the mitochondria that's our in the mitochondria that's our metabolism. metabolism. metabolism. >> Yes. And then I would just add to that >> Yes. And then I would just add to that >> Yes. And then I would just add to that that how we are able to address the that how we are able to address the that how we are able to address the stress of making energy as well in the stress of making energy as well in the stress of making energy as well in the sense that when we make energy we make sense that when we make energy we make sense that when we make energy we make ATP. We're also making waste products as ATP. We're also making waste products as ATP. We're also making waste products as I mentioned and that's the other part of I mentioned and that's the other part of I mentioned and that's the other part of metabolic health is that you're able to metabolic health is that you're able to metabolic health is that you're able to make energy effectively and you're able make energy effectively and you're able make energy effectively and you're able to neutralize the stress of making to neutralize the stress of making to neutralize the stress of making energy. But I love your definition energy. But I love your definition energy. But I love your definition because people get so confused by it so because people get so confused by it so because people get so confused by it so I appreciate you mentioning it. So when I appreciate you mentioning it. So when I appreciate you mentioning it. So when it comes down to brain health and mental it comes down to brain health and mental it comes down to brain health and mental health disorders, depression, bipolar, health disorders, depression, bipolar, health disorders, depression, bipolar, even schizophrenia and some of the major even schizophrenia and some of the major even schizophrenia and some of the major ones, like you see amazing capacity to ones, like you see amazing capacity to ones, like you see amazing capacity to work on mitochondrial function and see work on mitochondrial function and see work on mitochondrial function and see these things get so much better. I mean, these things get so much better. I mean, these things get so much better. I mean, people throw around and don't like the people throw around and don't like the people throw around and don't like the word cure, but in some cases, people word cure, but in some cases, people word cure, but in some cases, people coming off of of medications like coming off of of medications like coming off of of medications like entirely. And I've seen this entirely. And I've seen this entirely. And I've seen this >> like curing schizophrenia with diet and >> like curing schizophrenia with diet and >> like curing schizophrenia with diet and keto diet. keto diet. keto diet. >> It's amazing. And I, you know, I have a >> It's amazing. And I, you know, I have a >> It's amazing. And I, you know, I have a colleague that's on this with bipolar colleague that's on this with bipolar colleague that's on this with bipolar disorder, right? And so I feel like disorder, right? And so I feel like disorder, right? And so I feel like >> where it comes down to is that this is a >> where it comes down to is that this is a >> where it comes down to is that this is a mitochondrial dysfunction, at least a mitochondrial dysfunction, at least a mitochondrial dysfunction, at least a significant component of it. There might significant component of it. There might significant component of it. There might be neurochemical things for sure, but be neurochemical things for sure, but be neurochemical things for sure, but we, you know, you and I both know, I we, you know, you and I both know, I we, you know, you and I both know, I learned in medical school that learned in medical school that learned in medical school that depression was a serotonin deficiency, depression was a serotonin deficiency, depression was a serotonin deficiency, >> but we >> but we >> but we >> How did that work out? >> How did that work out? >> How did that work out? >> Not so bad. >> Not so bad. >> Not so bad. >> Wait, wait, wait. Depression isn't a >> Wait, wait, wait. Depression isn't a >> Wait, wait, wait. Depression isn't a Prozac deficiency. Prozac deficiency. Prozac deficiency. >> It's a Prozac deficiency, right? And so >> It's a Prozac deficiency, right? And so >> It's a Prozac deficiency, right? And so everybody, we need to put Prozac in the everybody, we need to put Prozac in the everybody, we need to put Prozac in the water. That was like not LSD anymore, water. That was like not LSD anymore, water. That was like not LSD anymore, but the Prozac. And we know now but the Prozac. And we know now but the Prozac. And we know now >> would be better. >> would be better. >> would be better. >> 100%. Yeah. of an interesting experiment >> 100%. Yeah. of an interesting experiment >> 100%. Yeah. of an interesting experiment in New York City back in the day. We in New York City back in the day. We in New York City back in the day. We know that depression is not a serotonin know that depression is not a serotonin know that depression is not a serotonin deficiency and we know that people that deficiency and we know that people that deficiency and we know that people that have depression have no lower levels of have depression have no lower levels of have depression have no lower levels of serotonin than people that don't have serotonin than people that don't have serotonin than people that don't have depression. Right? So I think that you depression. Right? So I think that you depression. Right? So I think that you know that's an interesting know that's an interesting know that's an interesting >> thing that we all learned that's >> thing that we all learned that's >> thing that we all learned that's completely wrong. Right? And that's what completely wrong. Right? And that's what completely wrong. Right? And that's what I learned in medical school and we now I learned in medical school and we now I learned in medical school and we now know that mitochondrial dysfunction is know that mitochondrial dysfunction is know that mitochondrial dysfunction is so much more of the the actual game so much more of the the actual game so much more of the the actual game here. Now understanding why people have here. Now understanding why people have here. Now understanding why people have the mitochondrial dysfunction is the mitochondrial dysfunction is the mitochondrial dysfunction is absolutely essential. We talked about absolutely essential. We talked about absolutely essential. We talked about the top down, the bottom up and how you the top down, the bottom up and how you the top down, the bottom up and how you have to address the causes for sure. But have to address the causes for sure. But have to address the causes for sure. But in the essence of this conversation, in the essence of this conversation, in the essence of this conversation, what I would say to those that are what I would say to those that are what I would say to those that are listening is that we can help people listening is that we can help people listening is that we can help people right now by working on mitochondrial right now by working on mitochondrial right now by working on mitochondrial function and sympathetic activation function and sympathetic activation function and sympathetic activation >> while longterm trying to figure out what >> while longterm trying to figure out what >> while longterm trying to figure out what those inputs are that are causing it those inputs are that are causing it those inputs are that are causing it too. Yeah. But seeing mitochondrial too. Yeah. But seeing mitochondrial too. Yeah. But seeing mitochondrial function improve and then all of a function improve and then all of a function improve and then all of a sudden depression, anxiety, insomnia sudden depression, anxiety, insomnia sudden depression, anxiety, insomnia >> get better is it's been transformative >> get better is it's been transformative >> get better is it's been transformative to people that I work with. to people that I work with. to people that I work with. >> No, it's huge. And I think I think just >> No, it's huge. And I think I think just >> No, it's huge. And I think I think just people should stay tuned to the end of people should stay tuned to the end of people should stay tuned to the end of this podcast. So, we're going to get to this podcast. So, we're going to get to this podcast. So, we're going to get to how to fix this, but I have a few more. how to fix this, but I have a few more. how to fix this, but I have a few more. >> No, I keep I keep foreshadowing. >> No, I keep I keep foreshadowing. >> No, I keep I keep foreshadowing. >> No, no, it's good. It's good. It's good. >> No, no, it's good. It's good. It's good. >> No, no, it's good. It's good. It's good. We're going to get there. Uh, We're going to get there. Uh, We're going to get there. Uh, at 66, I pay close attention to how my at 66, I pay close attention to how my at 66, I pay close attention to how my body feels, especially my energy, my body feels, especially my energy, my body feels, especially my energy, my strength, and my resilience. And aging strength, and my resilience. And aging strength, and my resilience. And aging doesn't mean we have to slow down or doesn't mean we have to slow down or doesn't mean we have to slow down or stop doing the things we love. And stop doing the things we love. 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One one of the ways you know is as One one of the ways you know is as One one of the ways you know is as people are listening I imagine they're people are listening I imagine they're people are listening I imagine they're thinking is well you know okay I know thinking is well you know okay I know thinking is well you know okay I know how to activate my parasympathetic how to activate my parasympathetic how to activate my parasympathetic system I can meditate I can do breath system I can meditate I can do breath system I can meditate I can do breath work I can do yoga I can maybe exercise work I can do yoga I can maybe exercise work I can do yoga I can maybe exercise to improve my mitochondria to improve my mitochondria to improve my mitochondria >> but you know co-plunches saunas whatever >> but you know co-plunches saunas whatever >> but you know co-plunches saunas whatever >> but you said something which is >> but you said something which is >> but you said something which is interesting you said you can't interesting you said you can't interesting you said you can't parasympathetic your way out of cell parasympathetic your way out of cell parasympathetic your way out of cell danger what does that mean danger what does that mean danger what does that mean >> so this is the thing right because >> so this is the thing right because >> so this is the thing right because >> you can't meditate your way out of this >> you can't meditate your way out of this >> you can't meditate your way out of this like physiological stress to your cells like physiological stress to your cells like physiological stress to your cells falls in mitochondria is what you're falls in mitochondria is what you're falls in mitochondria is what you're saying, right? saying, right? saying, right? >> Yeah. You can't I mean because you're in >> Yeah. You can't I mean because you're in >> Yeah. You can't I mean because you're in this sympathetic locked in kind of mode this sympathetic locked in kind of mode this sympathetic locked in kind of mode and the challenge is anytime you try to and the challenge is anytime you try to and the challenge is anytime you try to downregulate your nervous system, it downregulate your nervous system, it downregulate your nervous system, it actually might make you feel like you're actually might make you feel like you're actually might make you feel like you're crashing because when you try to get crashing because when you try to get crashing because when you try to get yourself out of sympathetic and get into yourself out of sympathetic and get into yourself out of sympathetic and get into parasympathetic, but you've been in parasympathetic, but you've been in parasympathetic, but you've been in sympathetic for a long period of time, sympathetic for a long period of time, sympathetic for a long period of time, so you're in that fight or flight. Your so you're in that fight or flight. Your so you're in that fight or flight. Your mitochondria, as we've been talking mitochondria, as we've been talking mitochondria, as we've been talking about, have been under a lot of stress about, have been under a lot of stress about, have been under a lot of stress for a while and we've depleted vitamins, for a while and we've depleted vitamins, for a while and we've depleted vitamins, minerals, nutrients. We're in that cell minerals, nutrients. We're in that cell minerals, nutrients. We're in that cell danger response. location of of your danger response. location of of your danger response. location of of your cell spectrum of capacity to make cell spectrum of capacity to make cell spectrum of capacity to make energy. And then you're trying to bring energy. And then you're trying to bring energy. And then you're trying to bring down the nervous system. down the nervous system. down the nervous system. >> But what can happen at when you do that >> But what can happen at when you do that >> But what can happen at when you do that is that you've only been able to is that you've only been able to is that you've only been able to function because you've been at that function because you've been at that function because you've been at that high of a state. And when you bring down high of a state. And when you bring down high of a state. And when you bring down the nervous system without enough the nervous system without enough the nervous system without enough support support support >> on the mitochondrial side, especially >> on the mitochondrial side, especially >> on the mitochondrial side, especially immune system really be helpful too. immune system really be helpful too. immune system really be helpful too. You'll see that you have this crash. You'll see that you have this crash. You'll see that you have this crash. People feel like they crash. they when People feel like they crash. they when People feel like they crash. they when they go down and try to do their breath they go down and try to do their breath they go down and try to do their breath work, try to do their meditation, often work, try to do their meditation, often work, try to do their meditation, often times they feel terrible when they try times they feel terrible when they try times they feel terrible when they try to do it, if they can even do it at the to do it, if they can even do it at the to do it, if they can even do it at the first in the first place because the first in the first place because the first in the first place because the other challenge of this too, Mark, is other challenge of this too, Mark, is other challenge of this too, Mark, is that people don't even know what it that people don't even know what it that people don't even know what it feels like to be back in parasympathetic feels like to be back in parasympathetic feels like to be back in parasympathetic mode. They don't even remember what it mode. They don't even remember what it mode. They don't even remember what it felt like to calm down their nervous felt like to calm down their nervous felt like to calm down their nervous system. And so it can be very difficult system. And so it can be very difficult system. And so it can be very difficult to do breath work or tell somebody to to do breath work or tell somebody to to do breath work or tell somebody to meditate or the last thing you want to meditate or the last thing you want to meditate or the last thing you want to do is to tell them to calm down, of do is to tell them to calm down, of do is to tell them to calm down, of course, right? That doesn't work. If if course, right? That doesn't work. If if course, right? That doesn't work. If if anybody's married or has a partner, they anybody's married or has a partner, they anybody's married or has a partner, they know rule number one of being married is know rule number one of being married is know rule number one of being married is that you don't tell your partner to calm that you don't tell your partner to calm that you don't tell your partner to calm down, right? Doesn't down, right? Doesn't down, right? Doesn't >> I was tell talking to my son who's eight >> I was tell talking to my son who's eight >> I was tell talking to my son who's eight and he's like, "Dad," he has three and he's like, "Dad," he has three and he's like, "Dad," he has three sisters, three older sisters and and my sisters, three older sisters and and my sisters, three older sisters and and my wife. He's like, "Dad, what are the wife. He's like, "Dad, what are the wife. He's like, "Dad, what are the things you never tell a girl?" I'm like, things you never tell a girl?" I'm like, things you never tell a girl?" I'm like, "Number one, do not tell them to calm "Number one, do not tell them to calm "Number one, do not tell them to calm down." down." down." >> Good advice. >> Good advice. >> Good advice. >> Yeah. Yeah. But, so that's the thing, >> Yeah. Yeah. But, so that's the thing, >> Yeah. Yeah. But, so that's the thing, right? If you're in this locked in state right? If you're in this locked in state right? If you're in this locked in state where you're in this metabolic where you're in this metabolic where you're in this metabolic dysfunction related to being in this dysfunction related to being in this dysfunction related to being in this cell danger response, not being able to cell danger response, not being able to cell danger response, not being able to make enough energy, you can't just make enough energy, you can't just make enough energy, you can't just breathe your way out of it. breathe your way out of it. breathe your way out of it. >> And so, you've got to really deal with >> And so, you've got to really deal with >> And so, you've got to really deal with those root causes. Like, you know, we those root causes. Like, you know, we those root causes. Like, you know, we say if you're mercury poisoned or you're say if you're mercury poisoned or you're say if you're mercury poisoned or you're vitro deficient, your thighs aren't vitro deficient, your thighs aren't vitro deficient, your thighs aren't working. It's hard to get enlightened. working. It's hard to get enlightened. working. It's hard to get enlightened. You know, you got to like you got to You know, you got to like you got to You know, you got to like you got to deal with those biological things. Yes. deal with those biological things. Yes. deal with those biological things. Yes. And then the often the psychological And then the often the psychological And then the often the psychological things or the or the physiological things or the or the physiological things or the or the physiological stress gets better, stress gets better, stress gets better, >> but it takes time. >> but it takes time. >> but it takes time. >> And, you know, it's interesting. I I I I >> And, you know, it's interesting. I I I I >> And, you know, it's interesting. I I I I really sort of fascinate when you came really sort of fascinate when you came really sort of fascinate when you came up with this because I I've noticed this up with this because I I've noticed this up with this because I I've noticed this for years in my practice. I was like, for years in my practice. I was like, for years in my practice. I was like, gosh, when people have a physical gosh, when people have a physical gosh, when people have a physical stress, meaning a toxin, an allergen, stress, meaning a toxin, an allergen, stress, meaning a toxin, an allergen, infection, it's poor diet, whatever, it infection, it's poor diet, whatever, it infection, it's poor diet, whatever, it actually causes a a actually causes a a actually causes a a like a a trouble with the whole system. like a a trouble with the whole system. like a a trouble with the whole system. Like it's not just Yeah. Like it's not just Yeah. Like it's not just Yeah. >> It's not just causing like a mental >> It's not just causing like a mental >> It's not just causing like a mental stress causing stress. It's it's stress causing stress. It's it's stress causing stress. It's it's physiological stress. Mercury is the physiological stress. Mercury is the physiological stress. Mercury is the same fight or flight, the same same fight or flight, the same same fight or flight, the same sympathetic activation, the same even if sympathetic activation, the same even if sympathetic activation, the same even if you even if you're kind of cool and you even if you're kind of cool and you even if you're kind of cool and everything's fine, you can still feel everything's fine, you can still feel everything's fine, you can still feel stressed because of having mercury in stressed because of having mercury in stressed because of having mercury in your system% for example. your system% for example. your system% for example. >> And I think that's something people >> And I think that's something people >> And I think that's something people don't realize. So they it's not just don't realize. So they it's not just don't realize. So they it's not just psychological, it can be biological psychological, it can be biological psychological, it can be biological causes of psychological stress. causes of psychological stress. causes of psychological stress. >> 100%. And and that's what I tell my >> 100%. And and that's what I tell my >> 100%. And and that's what I tell my patients all the time. It doesn't have patients all the time. It doesn't have patients all the time. It doesn't have to start with that sympathetic to start with that sympathetic to start with that sympathetic activation, but it it begins somewhere activation, but it it begins somewhere activation, but it it begins somewhere and then at some point they both often and then at some point they both often and then at some point they both often they both have to be addressed, right? they both have to be addressed, right? they both have to be addressed, right? Which is you can't just address the Which is you can't just address the Which is you can't just address the mercury exposure if you don't address mercury exposure if you don't address mercury exposure if you don't address also the sympathetic activation that was also the sympathetic activation that was also the sympathetic activation that was caused by the mercury exposure. Even if caused by the mercury exposure. Even if caused by the mercury exposure. Even if it wasn't a top- down issue before, it wasn't a top- down issue before, it wasn't a top- down issue before, maybe had some mild things in that that maybe had some mild things in that that maybe had some mild things in that that were stressful but not too bad, but all were stressful but not too bad, but all were stressful but not too bad, but all of a sudden you're mercury toxic. That's of a sudden you're mercury toxic. That's of a sudden you're mercury toxic. That's a different story. So when you work on a different story. So when you work on a different story. So when you work on mercury toxicity, you also have to work mercury toxicity, you also have to work mercury toxicity, you also have to work on the sympathetic activation, too. on the sympathetic activation, too. on the sympathetic activation, too. Because if you don't do them both, Because if you don't do them both, Because if you don't do them both, you're still going to be left in a place you're still going to be left in a place you're still going to be left in a place where you're still sympathetically where you're still sympathetically where you're still sympathetically activated. And you know how it is, like activated. And you know how it is, like activated. And you know how it is, like you've worked with patients like this, you've worked with patients like this, you've worked with patients like this, you know that if somebody's so fight you know that if somebody's so fight you know that if somebody's so fight orflight dominant, there's no healing orflight dominant, there's no healing orflight dominant, there's no healing that you can do with these patients. that you can do with these patients. that you can do with these patients. It's impossible and it's really It's impossible and it's really It's impossible and it's really difficult. It's like the one time I difficult. It's like the one time I difficult. It's like the one time I agree with our conventional colleagues agree with our conventional colleagues agree with our conventional colleagues that if you're giving them supplements, that if you're giving them supplements, that if you're giving them supplements, it's like giving them expensive urine. it's like giving them expensive urine. it's like giving them expensive urine. you know, if you're not addressing the you know, if you're not addressing the you know, if you're not addressing the root the sympathetic activation along root the sympathetic activation along root the sympathetic activation along with the root cause if it was with the root cause if it was with the root cause if it was mitochondrial first, right? And so mitochondrial first, right? And so mitochondrial first, right? And so that's why it's so nuanced here and but that's why it's so nuanced here and but that's why it's so nuanced here and but it's so important to kind of piece this it's so important to kind of piece this it's so important to kind of piece this out as you are and discuss it. out as you are and discuss it. out as you are and discuss it. >> But then even like the mitochondrial >> But then even like the mitochondrial >> But then even like the mitochondrial stress from toxins or whatever, stress from toxins or whatever, stress from toxins or whatever, >> it it it actually makes the body stay in >> it it it actually makes the body stay in >> it it it actually makes the body stay in fight or flight. Yeah. So how explain fight or flight. Yeah. So how explain fight or flight. Yeah. So how explain that connection between the that connection between the that connection between the mitochondrial stress from things that mitochondrial stress from things that mitochondrial stress from things that are just insults that you didn't have to are just insults that you didn't have to are just insults that you didn't have to do do it like that are not mental do do it like that are not mental do do it like that are not mental insults causing this you to be in this insults causing this you to be in this insults causing this you to be in this mental state of fight or flight mental state of fight or flight mental state of fight or flight >> right so the idea is that when you have >> right so the idea is that when you have >> right so the idea is that when you have a lot of mitochondrial stress you're not a lot of mitochondrial stress you're not a lot of mitochondrial stress you're not making enough energy okay and when making enough energy okay and when making enough energy okay and when you're not making enough energy the you're not making enough energy the you're not making enough energy the system goes oh no I need more energy and system goes oh no I need more energy and system goes oh no I need more energy and what it does is it tries to compensate what it does is it tries to compensate what it does is it tries to compensate by increasing your sympathetic nervous by increasing your sympathetic nervous by increasing your sympathetic nervous system increasing your capacity to find system increasing your capacity to find system increasing your capacity to find out psy psychologically how you can help out psy psychologically how you can help out psy psychologically how you can help the situation. So it's almost like it's the situation. So it's almost like it's the situation. So it's almost like it's a bottom up where you have these a bottom up where you have these a bottom up where you have these sensations and activation of sensations and activation of sensations and activation of inflammatory pathways and etc in the inflammatory pathways and etc in the inflammatory pathways and etc in the body related to mitochondrial body related to mitochondrial body related to mitochondrial dysfunction that overtly psychologically dysfunction that overtly psychologically dysfunction that overtly psychologically this manifests in you trying to figure this manifests in you trying to figure this manifests in you trying to figure out why this is happening or trying to out why this is happening or trying to out why this is happening or trying to give you more energy so to maintain the give you more energy so to maintain the give you more energy so to maintain the capacity that you need to make any capacity that you need to make any capacity that you need to make any energy at all. And so you get in this in energy at all. And so you get in this in energy at all. And so you get in this in this loop where it doesn't have to be this loop where it doesn't have to be this loop where it doesn't have to be any that that over sympathetic any that that over sympathetic any that that over sympathetic activation from outside sources. All of activation from outside sources. All of activation from outside sources. All of a sudden it's just the mitochondria a sudden it's just the mitochondria a sudden it's just the mitochondria itself that are not making enough energy itself that are not making enough energy itself that are not making enough energy and then causing the system to and then causing the system to and then causing the system to compensate for that. compensate for that. compensate for that. >> Okay. So let me see if I get this >> Okay. So let me see if I get this >> Okay. So let me see if I get this straight. You we've got this this thing straight. You we've got this this thing straight. You we've got this this thing that you describe which is something I that you describe which is something I that you describe which is something I think most of us who practice this way think most of us who practice this way think most of us who practice this way for years have already seen. We never for years have already seen. We never for years have already seen. We never called it this but the sympathetic called it this but the sympathetic called it this but the sympathetic spiral of doom. spiral of doom. spiral of doom. >> Yeah. >> Yeah. >> Yeah. >> Which can come from the top down bottom >> Which can come from the top down bottom >> Which can come from the top down bottom up. It's a lot of mitochondrial up. It's a lot of mitochondrial up. It's a lot of mitochondrial dysfunction, stress, a lot of inability dysfunction, stress, a lot of inability dysfunction, stress, a lot of inability to produce energy in our cells which to produce energy in our cells which to produce energy in our cells which runs everything, runs everything, runs everything, >> right? >> right? >> right? >> And we end up in this cell danger >> And we end up in this cell danger >> And we end up in this cell danger response. So we've got like sympathetic response. So we've got like sympathetic response. So we've got like sympathetic spiralum cell danger response. So people spiralum cell danger response. So people spiralum cell danger response. So people listening go, "Yeah, that's me, right? listening go, "Yeah, that's me, right? listening go, "Yeah, that's me, right? I'm listening go, yeah, that's kind of I'm listening go, yeah, that's kind of I'm listening go, yeah, that's kind of me." So like what do we do? Like what if me." So like what do we do? Like what if me." So like what do we do? Like what if someone's stuck? How do what's the first someone's stuck? How do what's the first someone's stuck? How do what's the first step to getting out of this this loop? step to getting out of this this loop? step to getting out of this this loop? The first step, the spiral of doom, The first step, the spiral of doom, The first step, the spiral of doom, >> the spiral is is to escape the spiral. >> the spiral is is to escape the spiral. >> the spiral is is to escape the spiral. That's what you want to do over the long That's what you want to do over the long That's what you want to do over the long term. But initially, you want to figure term. But initially, you want to figure term. But initially, you want to figure out ways to help somebody now to help out ways to help somebody now to help out ways to help somebody now to help break the spiral and get them additional break the spiral and get them additional break the spiral and get them additional support so they actually can maintain support so they actually can maintain support so they actually can maintain and benefit from long-term support. So, and benefit from long-term support. So, and benefit from long-term support. So, the idea is that you were you're a the idea is that you were you're a the idea is that you were you're a functional medicine expert. You founded functional medicine expert. You founded functional medicine expert. You founded the field basically with Jeff and the field basically with Jeff and the field basically with Jeff and others. you know that working with others. you know that working with others. you know that working with people and optimizing their health, people and optimizing their health, people and optimizing their health, vitamins, minerals, nutrients, vitamins, minerals, nutrients, vitamins, minerals, nutrients, optimizing their gut, the optimizing their gut, the optimizing their gut, the neurotransmitters, that can take a long neurotransmitters, that can take a long neurotransmitters, that can take a long time to do, right? Yeah. And if you're time to do, right? Yeah. And if you're time to do, right? Yeah. And if you're in this spiral, it's very difficult to in this spiral, it's very difficult to in this spiral, it's very difficult to do as well because again, you're clamped do as well because again, you're clamped do as well because again, you're clamped down. You're sympathetically activated. down. You're sympathetically activated. down. You're sympathetically activated. So, the goal of breaking the spiral is So, the goal of breaking the spiral is So, the goal of breaking the spiral is to support the mitochondria now as much to support the mitochondria now as much to support the mitochondria now as much as possible and at the same time slowly as possible and at the same time slowly as possible and at the same time slowly start downregulating the sympathetic start downregulating the sympathetic start downregulating the sympathetic activation, slowly downregulating the activation, slowly downregulating the activation, slowly downregulating the nervous system so it can calm down. But nervous system so it can calm down. But nervous system so it can calm down. But you have to do it in that order. You you have to do it in that order. You you have to do it in that order. You have to start off with supporting have to start off with supporting have to start off with supporting mitochondrial first, mitochondrial mitochondrial first, mitochondrial mitochondrial first, mitochondrial function first. function first. function first. >> So it's not meditate first and then it's >> So it's not meditate first and then it's >> So it's not meditate first and then it's fix your mitochondria first then fix your mitochondria first then fix your mitochondria first then meditate meditate meditate >> because what can happen is if you go too >> because what can happen is if you go too >> because what can happen is if you go too soon on the parasympathetic side trying soon on the parasympathetic side trying soon on the parasympathetic side trying to calm down the nervous system without to calm down the nervous system without to calm down the nervous system without having mitochondrial support. That's having mitochondrial support. That's having mitochondrial support. That's when you get into trouble too because when you get into trouble too because when you get into trouble too because you physically and mentally can't you physically and mentally can't you physically and mentally can't compensate because you don't have enough compensate because you don't have enough compensate because you don't have enough energy capacity. And so your energy energy capacity. And so your energy energy capacity. And so your energy capacity is still low. You've capacity is still low. You've capacity is still low. You've downregulated your nervous system and downregulated your nervous system and downregulated your nervous system and now the sympathetic activation, the now the sympathetic activation, the now the sympathetic activation, the fight or flight is down. You're trying fight or flight is down. You're trying fight or flight is down. You're trying to calm down the nervous system and but to calm down the nervous system and but to calm down the nervous system and but you don't have energy that you can make. you don't have energy that you can make. you don't have energy that you can make. You don't have enough energy. And so as You don't have enough energy. And so as You don't have enough energy. And so as a result of that, you crash. And I've a result of that, you crash. And I've a result of that, you crash. And I've seen this in in my practice all the time seen this in in my practice all the time seen this in in my practice all the time where if you start working on the where if you start working on the where if you start working on the nervous system too soon, people crash. nervous system too soon, people crash. nervous system too soon, people crash. And so the key is to work on And so the key is to work on And so the key is to work on mitochondrial function now and give mitochondrial function now and give mitochondrial function now and give immediate support so that when you start immediate support so that when you start immediate support so that when you start downregulating and calming down that downregulating and calming down that downregulating and calming down that this nervous system has enough capacity this nervous system has enough capacity this nervous system has enough capacity the whole system has enough capacity the whole system has enough capacity the whole system has enough capacity because the mitochondria is supported. because the mitochondria is supported. because the mitochondria is supported. >> Okay. So let's talk about that. How how >> Okay. So let's talk about that. How how >> Okay. So let's talk about that. How how do we fix mitochondria because it do we fix mitochondria because it do we fix mitochondria because it certainly wasn't something that we all certainly wasn't something that we all certainly wasn't something that we all learned in medical school. It's it's learned in medical school. It's it's learned in medical school. It's it's something that's one of the central something that's one of the central something that's one of the central features of functional medicine which is features of functional medicine which is features of functional medicine which is understanding how to diagnose and treat understanding how to diagnose and treat understanding how to diagnose and treat mitochondrial dysfunction. Right. It's a mitochondrial dysfunction. Right. It's a mitochondrial dysfunction. Right. It's a little bit tricky because you know the little bit tricky because you know the little bit tricky because you know the best way to look at mitochondria is do a best way to look at mitochondria is do a best way to look at mitochondria is do a muscle biopsy but that's not fun. muscle biopsy but that's not fun. muscle biopsy but that's not fun. >> Um but there are other other tests. How >> Um but there are other other tests. How >> Um but there are other other tests. How how do you how do you think about how do you how do you think about how do you how do you think about approaching mitochondrial dysfunction? approaching mitochondrial dysfunction? approaching mitochondrial dysfunction? Cuz yes it's got to be focusing on the Cuz yes it's got to be focusing on the Cuz yes it's got to be focusing on the causes like if you're eating something causes like if you're eating something causes like if you're eating something that's bad or if you're got exposure to that's bad or if you're got exposure to that's bad or if you're got exposure to toxins but let's assuming you're you're toxins but let's assuming you're you're toxins but let's assuming you're you're you're working on those because you have you're working on those because you have you're working on those because you have to. What else can you do to revive these to. What else can you do to revive these to. What else can you do to revive these little poor baby little mitochondria little poor baby little mitochondria little poor baby little mitochondria that don't feel so good? Well, I think that don't feel so good? Well, I think that don't feel so good? Well, I think you're kind of alluding to the idea of you're kind of alluding to the idea of you're kind of alluding to the idea of testing to see how mitochondria are testing to see how mitochondria are testing to see how mitochondria are working. And there are new tests out working. And there are new tests out working. And there are new tests out there that are working on giving you a there that are working on giving you a there that are working on giving you a direct sense of what's happening in the direct sense of what's happening in the direct sense of what's happening in the mitochondria. And there maybe are there mitochondria. And there maybe are there mitochondria. And there maybe are there are a number of them that are on the are a number of them that are on the are a number of them that are on the market already. Some of them might be market already. Some of them might be market already. Some of them might be more ready for prime time than others. more ready for prime time than others. more ready for prime time than others. >> What do you think is the the >> What do you think is the the >> What do you think is the the >> Well, I mean, there's there's a couple >> Well, I mean, there's there's a couple >> Well, I mean, there's there's a couple out there. I mean, the ones that I use out there. I mean, the ones that I use out there. I mean, the ones that I use are more the indirect measures like you are more the indirect measures like you are more the indirect measures like you do like organic acid testing, for do like organic acid testing, for do like organic acid testing, for example, looking at uh the intermediates example, looking at uh the intermediates example, looking at uh the intermediates that are associated with making energy that are associated with making energy that are associated with making energy and also oxidative stress markers, and also oxidative stress markers, and also oxidative stress markers, inflammatory markers. Those are really inflammatory markers. Those are really inflammatory markers. Those are really good indicators really of mitochondrial good indicators really of mitochondrial good indicators really of mitochondrial function. There's things like miscreen function. There's things like miscreen function. There's things like miscreen and mito and others that are out there and mito and others that are out there and mito and others that are out there that I think are interesting. I think that I think are interesting. I think that I think are interesting. I think they're they're new. they're they're new. they're they're new. >> Yeah. >> Yeah. >> Yeah. >> In the end, what I see here is they're >> In the end, what I see here is they're >> In the end, what I see here is they're it's really nice to have the data for it's really nice to have the data for it's really nice to have the data for sure because then you can get a sense of sure because then you can get a sense of sure because then you can get a sense of how people do over time. how people do over time. how people do over time. >> But so much of this, as you know, Mark >> But so much of this, as you know, Mark >> But so much of this, as you know, Mark is subjective and people really do know is subjective and people really do know is subjective and people really do know how they feel. If you even guys who are how they feel. If you even guys who are how they feel. If you even guys who are not as good as women as we know about not as good as women as we know about not as good as women as we know about telling you how they feel, like, well, telling you how they feel, like, well, telling you how they feel, like, well, how did you feel last, you know, 5 years how did you feel last, you know, 5 years how did you feel last, you know, 5 years ago? Tell me about your energy now ago? Tell me about your energy now ago? Tell me about your energy now versus 5 years ago. like, oh yeah, I had versus 5 years ago. like, oh yeah, I had versus 5 years ago. like, oh yeah, I had a lot of energy. I had no issues and now a lot of energy. I had no issues and now a lot of energy. I had no issues and now I I get brain fog. I get that dip during I I get brain fog. I get that dip during I I get brain fog. I get that dip during the day and I feel terri like people can the day and I feel terri like people can the day and I feel terri like people can typically give you a sense. So typically give you a sense. So typically give you a sense. So subjectively such a big part of this and subjectively such a big part of this and subjectively such a big part of this and when that's hard, but it's so important when that's hard, but it's so important when that's hard, but it's so important because it's how you feel on some level, because it's how you feel on some level, because it's how you feel on some level, but what it comes down to is that when but what it comes down to is that when but what it comes down to is that when you're looking at optimizing you're looking at optimizing you're looking at optimizing mitochondrial function, it is giving the mitochondrial function, it is giving the mitochondrial function, it is giving the mitochondria what it needs to make mitochondria what it needs to make mitochondria what it needs to make energy effectively and to address the energy effectively and to address the energy effectively and to address the stress of making energy. stress of making energy. stress of making energy. >> Vitamins, minerals, nutrients, >> Vitamins, minerals, nutrients, >> Vitamins, minerals, nutrients, antioxidants, getting rid of heavy antioxidants, getting rid of heavy antioxidants, getting rid of heavy metals. this is your work. This is my metals. this is your work. This is my metals. this is your work. This is my work. The challenge with all of that work. The challenge with all of that work. The challenge with all of that though is that it takes time. though is that it takes time. though is that it takes time. >> Yeah. >> Yeah. >> Yeah. >> It doesn't happen overnight. And so I've >> It doesn't happen overnight. And so I've >> It doesn't happen overnight. And so I've kind of fallen in love with a compound kind of fallen in love with a compound kind of fallen in love with a compound called methylene blue that you know of called methylene blue that you know of called methylene blue that you know of >> that is a very novel compound in some >> that is a very novel compound in some >> that is a very novel compound in some respects, but it's been around for a respects, but it's been around for a respects, but it's been around for a long time. But it's one of the most long time. But it's one of the most long time. But it's one of the most effective ways at supporting effective ways at supporting effective ways at supporting mitochondrial function right now. mitochondrial function right now. mitochondrial function right now. >> And the reason is that it works on the >> And the reason is that it works on the >> And the reason is that it works on the energy production cycle of things. It energy production cycle of things. It energy production cycle of things. It helps with energy production and it also helps with energy production and it also helps with energy production and it also works directly like an antioxidant. So works directly like an antioxidant. So works directly like an antioxidant. So our cells are like gasoline powered our cells are like gasoline powered our cells are like gasoline powered cars. Methylene blue at low doses as cars. Methylene blue at low doses as cars. Methylene blue at low doses as long as it's a clean source 4 millig to long as it's a clean source 4 millig to long as it's a clean source 4 millig to 25 milligrams or so works both as an 25 milligrams or so works both as an 25 milligrams or so works both as an energy enhancer and as a detoxifier. So energy enhancer and as a detoxifier. So energy enhancer and as a detoxifier. So it more like an electric power vehicle it more like an electric power vehicle it more like an electric power vehicle rather than a gasoline powered one. And rather than a gasoline powered one. And rather than a gasoline powered one. And so it's become one of these big levers so it's become one of these big levers so it's become one of these big levers that I can pull with patients to be a that I can pull with patients to be a that I can pull with patients to be a bridge to be that bridge. I like a bridge to be that bridge. I like a bridge to be that bridge. I like a picture. I I often will put up a picture picture. I I often will put up a picture picture. I I often will put up a picture of the Brooklyn Bridge. I love the of the Brooklyn Bridge. I love the of the Brooklyn Bridge. I love the Brooklyn Bridge. I grew up in New York. Brooklyn Bridge. I grew up in New York. Brooklyn Bridge. I grew up in New York. And it's this bridge where you can help And it's this bridge where you can help And it's this bridge where you can help people right now while they're on that people right now while they're on that people right now while they're on that path. So, if you're starting at like path. So, if you're starting at like path. So, if you're starting at like letter A through H or something in the letter A through H or something in the letter A through H or something in the alphabet on your path to optimizing your alphabet on your path to optimizing your alphabet on your path to optimizing your health, that first beginning can be health, that first beginning can be health, that first beginning can be really hard. Really hard because you really hard. Really hard because you really hard. Really hard because you don't have energy to go take a walk don't have energy to go take a walk don't have energy to go take a walk around the block. You don't have enough around the block. You don't have enough around the block. You don't have enough energy to make your own food. You don't energy to make your own food. You don't energy to make your own food. You don't have enough energy to maybe get out of a have enough energy to maybe get out of a have enough energy to maybe get out of a relationship that's toxic, right? But relationship that's toxic, right? But relationship that's toxic, right? But once you start giving people enough once you start giving people enough once you start giving people enough energy, supporting that capacity without energy, supporting that capacity without energy, supporting that capacity without causing stress on the system, that's causing stress on the system, that's causing stress on the system, that's when they can make huge gains across the when they can make huge gains across the when they can make huge gains across the alphabet in my analogy here, getting alphabet in my analogy here, getting alphabet in my analogy here, getting them to LM O, or whatever. And then them to LM O, or whatever. And then them to LM O, or whatever. And then they're able to start really making they're able to start really making they're able to start really making changes that they really want to make. changes that they really want to make. changes that they really want to make. And so I see methylene blue as a And so I see methylene blue as a And so I see methylene blue as a fantastic bridge for so many people on fantastic bridge for so many people on fantastic bridge for so many people on this path to their own health this path to their own health this path to their own health optimization journey, optimization journey, optimization journey, >> you know, and the mechanism of action is >> you know, and the mechanism of action is >> you know, and the mechanism of action is really interesting, right? It it kind of really interesting, right? It it kind of really interesting, right? It it kind of acts as an electron carrier. acts as an electron carrier. acts as an electron carrier. >> Yeah. which is what electrons are really >> Yeah. which is what electrons are really >> Yeah. which is what electrons are really what goes through this little what goes through this little what goes through this little mitochondrial you know assembly line to mitochondrial you know assembly line to mitochondrial you know assembly line to make energy to make ATP and it kind of make energy to make ATP and it kind of make energy to make ATP and it kind of bypasses some of the complexes like two bypasses some of the complexes like two bypasses some of the complexes like two and three that are kind of in the way so and three that are kind of in the way so and three that are kind of in the way so if there's mitochondrial dysfunction it if there's mitochondrial dysfunction it if there's mitochondrial dysfunction it kind of like leaprogs over it a little kind of like leaprogs over it a little kind of like leaprogs over it a little bit right bit right bit right >> yep it bypasses >> yep it bypasses >> yep it bypasses >> and then you get more ATP and you get >> and then you get more ATP and you get >> and then you get more ATP and you get less oxidative stress in my practice you less oxidative stress in my practice you less oxidative stress in my practice you know one of the doctors was sharing with know one of the doctors was sharing with know one of the doctors was sharing with me how they were doing intravenous me how they were doing intravenous me how they were doing intravenous methylene blue and how they had a methylene blue and how they had a methylene blue and how they had a Parkinson's patient and they immediately Parkinson's patient and they immediately Parkinson's patient and they immediately improved their symptoms and and I don't improved their symptoms and and I don't improved their symptoms and and I don't know if it was a long-lasting effect, know if it was a long-lasting effect, know if it was a long-lasting effect, but it was an incredible thing because but it was an incredible thing because but it was an incredible thing because we know that Parkinson's is we know that Parkinson's is we know that Parkinson's is fundamentally a mitochondrial disease in fundamentally a mitochondrial disease in fundamentally a mitochondrial disease in the part of the brain that has to do the part of the brain that has to do the part of the brain that has to do with motor function, right? with motor function, right? with motor function, right? >> And so, can you kind of explain how that >> And so, can you kind of explain how that >> And so, can you kind of explain how that might all be possible? might all be possible? might all be possible? >> Yeah. So, in the end, neurocognitive >> Yeah. So, in the end, neurocognitive >> Yeah. So, in the end, neurocognitive disease, metabolic as we've been talking disease, metabolic as we've been talking disease, metabolic as we've been talking about, everything has these parts of the about, everything has these parts of the about, everything has these parts of the cell called the mitochondria that help cell called the mitochondria that help cell called the mitochondria that help make energy, your immune system, make energy, your immune system, make energy, your immune system, everything. And so if your mitochondria everything. And so if your mitochondria everything. And so if your mitochondria aren't working well, you have aren't working well, you have aren't working well, you have significant incapacity in the areas that significant incapacity in the areas that significant incapacity in the areas that have the most mitochondria that are have the most mitochondria that are have the most mitochondria that are affected. And so in Parkinson's, you affected. And so in Parkinson's, you affected. And so in Parkinson's, you know, it's in the substantia in know, it's in the substantia in know, it's in the substantia in the brain, for example. So one cool the brain, for example. So one cool the brain, for example. So one cool thing about methylene blue I should thing about methylene blue I should thing about methylene blue I should mention is that it is highly mention is that it is highly mention is that it is highly bioavailable, which means that orally bioavailable, which means that orally bioavailable, which means that orally absorption, oral absorption of methane absorption, oral absorption of methane absorption, oral absorption of methane blue is almost as good as IV. The only blue is almost as good as IV. The only blue is almost as good as IV. The only difference with IV is that how fast it difference with IV is that how fast it difference with IV is that how fast it gets in the body. But most people don't gets in the body. But most people don't gets in the body. But most people don't need IV. Most people can use oral and need IV. Most people can use oral and need IV. Most people can use oral and get the same mitochondrial benefits. And get the same mitochondrial benefits. And get the same mitochondrial benefits. And so what you were describing on on what's so what you were describing on on what's so what you were describing on on what's called the electron transport chain in called the electron transport chain in called the electron transport chain in the mitochondria. So the mitochondria the mitochondria. So the mitochondria the mitochondria. So the mitochondria has these proteins that are all kind of has these proteins that are all kind of has these proteins that are all kind of aligned up and electrons that we get aligned up and electrons that we get aligned up and electrons that we get from our food mostly carbohydrates and from our food mostly carbohydrates and from our food mostly carbohydrates and fat. They get donated to this chain fat. They get donated to this chain fat. They get donated to this chain using something called NAD and FAD which using something called NAD and FAD which using something called NAD and FAD which people know NAD these days right um people know NAD these days right um people know NAD these days right um that's a hot topic I know. So you get that's a hot topic I know. So you get that's a hot topic I know. So you get these carriers electron carriers NAD and these carriers electron carriers NAD and these carriers electron carriers NAD and FAD that bring electrons into the FAD that bring electrons into the FAD that bring electrons into the mitochondria. So what happens is if you mitochondria. So what happens is if you mitochondria. So what happens is if you have those first couple proteins not have those first couple proteins not have those first couple proteins not working very well, complex one or working very well, complex one or working very well, complex one or complex 2, the whole rest of the system complex 2, the whole rest of the system complex 2, the whole rest of the system breaks down. You don't have capacity to breaks down. You don't have capacity to breaks down. You don't have capacity to make energy. And most of the the make energy. And most of the the make energy. And most of the the mitochondrial toxins out there are mitochondrial toxins out there are mitochondrial toxins out there are affecting complex one and complex 2. We affecting complex one and complex 2. We affecting complex one and complex 2. We talked about statins. We talked about talked about statins. We talked about talked about statins. We talked about metformin infections, pesticides, more metformin infections, pesticides, more metformin infections, pesticides, more are affecting those first four are affecting those first four are affecting those first four complexes, those first two complexes, complexes, those first two complexes, complexes, those first two complexes, excuse me. And so if those first couple excuse me. And so if those first couple excuse me. And so if those first couple complexes aren't working, the rest of complexes aren't working, the rest of complexes aren't working, the rest of the system breaks down. So what the system breaks down. So what the system breaks down. So what methylene blue can do is it can come in, methylene blue can do is it can come in, methylene blue can do is it can come in, it can bypass the complexes that aren't it can bypass the complexes that aren't it can bypass the complexes that aren't working very well and donate electrons working very well and donate electrons working very well and donate electrons directly up the chain. So all of a directly up the chain. So all of a directly up the chain. So all of a sudden you're able to start making sudden you're able to start making sudden you're able to start making energy in these cells. energy in these cells. energy in these cells. >> So it's almost like a bypass road. If >> So it's almost like a bypass road. If >> So it's almost like a bypass road. If there's a broken road, you just kind of there's a broken road, you just kind of there's a broken road, you just kind of goes around it. goes around it. goes around it. >> Yes. And it also can recycle things like >> Yes. And it also can recycle things like >> Yes. And it also can recycle things like NAD and FAD. So those can maintain their NAD and FAD. So those can maintain their NAD and FAD. So those can maintain their capacity to take electrons from your capacity to take electrons from your capacity to take electrons from your food even if those particular complexes food even if those particular complexes food even if those particular complexes aren't working as well as they needed aren't working as well as they needed aren't working as well as they needed to. So it's this amazing capacity to to. So it's this amazing capacity to to. So it's this amazing capacity to bypass and compensate for almost any bypass and compensate for almost any bypass and compensate for almost any capacity or incapacity of the electron capacity or incapacity of the electron capacity or incapacity of the electron transport chain to work and that even transport chain to work and that even transport chain to work and that even even to the much as so as it's actually even to the much as so as it's actually even to the much as so as it's actually the antidote for cyanide poisoning. So the antidote for cyanide poisoning. So the antidote for cyanide poisoning. So cyanide cyanide cyanide >> right >> right >> right >> is actually a >> is actually a >> is actually a >> kills you by stopping your mitochondria >> kills you by stopping your mitochondria >> kills you by stopping your mitochondria from working from working from working >> complex 4. So the four the fourth >> complex 4. So the four the fourth >> complex 4. So the four the fourth complex in the mitochondria complex 4 is complex in the mitochondria complex 4 is complex in the mitochondria complex 4 is destroyed by cyanide. And what methylene destroyed by cyanide. And what methylene destroyed by cyanide. And what methylene blue can do is it does these ninja moves blue can do is it does these ninja moves blue can do is it does these ninja moves of going across membranes and being an of going across membranes and being an of going across membranes and being an electron acceptor so you can maintain electron acceptor so you can maintain electron acceptor so you can maintain electron flow through those protein electron flow through those protein electron flow through those protein complexes even if you're poisoned by complexes even if you're poisoned by complexes even if you're poisoned by cyanide. And so that's just cyanide. And so that's just cyanide. And so that's just demonstrating the power of this demonstrating the power of this demonstrating the power of this particular particular particular >> and it's actually how I learned about it >> and it's actually how I learned about it >> and it's actually how I learned about it was in the emergency room as an was in the emergency room as an was in the emergency room as an emergency room doctor. If someone comes emergency room doctor. If someone comes emergency room doctor. If someone comes with cyanide poisoning this is the drug with cyanide poisoning this is the drug with cyanide poisoning this is the drug that you give to cure people like that you give to cure people like that you give to cure people like >> right it's not common but it's there. >> right it's not common but it's there. >> right it's not common but it's there. There's another one called med he There's another one called med he There's another one called med he hemoglobinia which is more common and hemoglobinia which is more common and hemoglobinia which is more common and that's also why it's used in emergency that's also why it's used in emergency that's also why it's used in emergency rooms all over the country. from carbon rooms all over the country. from carbon rooms all over the country. from carbon monoxide poisoning. monoxide poisoning. monoxide poisoning. >> Carbonoxide poisoning and also if you've >> Carbonoxide poisoning and also if you've >> Carbonoxide poisoning and also if you've like the huffing glue or like the that like the huffing glue or like the that like the huffing glue or like the that stuff if you have too much of that that stuff if you have too much of that that stuff if you have too much of that that gives you the incapacity to carry oxygen gives you the incapacity to carry oxygen gives you the incapacity to carry oxygen on your red blood cells and methane blue on your red blood cells and methane blue on your red blood cells and methane blue changes the the um the the the iron changes the the um the the the iron changes the the um the the the iron state to make sure that you can state to make sure that you can state to make sure that you can >> and the and it also it also acts as a an >> and the and it also it also acts as a an >> and the and it also it also acts as a an MAO inhibitor which is MAO is like a MAO inhibitor which is MAO is like a MAO inhibitor which is MAO is like a monoamine oxidase it's regulates monoamine oxidase it's regulates monoamine oxidase it's regulates neurotransmitter function but you got neurotransmitter function but you got neurotransmitter function but you got higher serotonin dopamine or epinephrine higher serotonin dopamine or epinephrine higher serotonin dopamine or epinephrine it can have improved mood neurocognitive it can have improved mood neurocognitive it can have improved mood neurocognitive effects right effects right effects right >> so it's dose dependent so lower dose >> so it's dose dependent so lower dose >> so it's dose dependent so lower dose doses of methylene blue will increase doses of methylene blue will increase doses of methylene blue will increase norepinephrine and serotonin. norepinephrine and serotonin. norepinephrine and serotonin. >> Um, higher doses will also increase >> Um, higher doses will also increase >> Um, higher doses will also increase dopamine once you get to about 100 dopamine once you get to about 100 dopamine once you get to about 100 milligrams or so. The key, as I milligrams or so. The key, as I milligrams or so. The key, as I mentioned, is that it's dose dependent, mentioned, is that it's dose dependent, mentioned, is that it's dose dependent, meaning that a little bit will do a meaning that a little bit will do a meaning that a little bit will do a little bit of that and more of it will little bit of that and more of it will little bit of that and more of it will do more. So, there are people that have do more. So, there are people that have do more. So, there are people that have talked about how methane blue just helps talked about how methane blue just helps talked about how methane blue just helps people feel better because it increases people feel better because it increases people feel better because it increases serotonin, but that's not the case at serotonin, but that's not the case at serotonin, but that's not the case at all. Right? We're talking about small all. Right? We're talking about small all. Right? We're talking about small amounts compared to the huge effect on amounts compared to the huge effect on amounts compared to the huge effect on mitochondrial function. People listening mitochondrial function. People listening mitochondrial function. People listening want to know how to take it like you want to know how to take it like you want to know how to take it like you know what are the doses like how do you know what are the doses like how do you know what are the doses like how do you do it you know I see a lot of people do it you know I see a lot of people do it you know I see a lot of people like sucking on these lozenes it makes like sucking on these lozenes it makes like sucking on these lozenes it makes their tongue all blue their tongue all blue their tongue all blue >> they can just swallow it it's okay >> they can just swallow it it's okay >> they can just swallow it it's okay swallow it swallow it right yeah because swallow it swallow it right yeah because swallow it swallow it right yeah because as I mentioned it's almost 100% as I mentioned it's almost 100% as I mentioned it's almost 100% bioavailable which means if you ingest bioavailable which means if you ingest bioavailable which means if you ingest it whether you dissolve in the mouth as it whether you dissolve in the mouth as it whether you dissolve in the mouth as a troy or if you swallow it um you can a troy or if you swallow it um you can a troy or if you swallow it um you can get the same mitochondrial benefits the get the same mitochondrial benefits the get the same mitochondrial benefits the key here Mark and I think this is key here Mark and I think this is key here Mark and I think this is important for your audience to know is important for your audience to know is important for your audience to know is that that that >> methylene blue is not a natural compound >> methylene blue is not a natural compound >> methylene blue is not a natural compound it doesn't come from the earth it's a it doesn't come from the earth it's a it doesn't come from the earth it's a synthetic ingredient and as a result of synthetic ingredient and as a result of synthetic ingredient and as a result of that that that >> it can be sometimes contaminated with >> it can be sometimes contaminated with >> it can be sometimes contaminated with heavy metals things like lead mercury heavy metals things like lead mercury heavy metals things like lead mercury cadmium and arsenic okay cadmium and arsenic okay cadmium and arsenic okay >> in the manufacturing >> in the manufacturing >> in the manufacturing >> in the manu in the manufacturing process >> in the manu in the manufacturing process >> in the manu in the manufacturing process and so to take the synthetic thing just and so to take the synthetic thing just and so to take the synthetic thing just for a minute because I know some people for a minute because I know some people for a minute because I know some people don't like the idea of taking any don't like the idea of taking any don't like the idea of taking any anything synthetic anything synthetic anything synthetic >> the way I like to talk about this is >> the way I like to talk about this is >> the way I like to talk about this is that not not everything natural is good that not not everything natural is good that not not everything natural is good for us okay you can forage for us okay you can forage for us okay you can forage >> arsenic is yeah mushrooms would kill you >> arsenic is yeah mushrooms would kill you >> arsenic is yeah mushrooms would kill you right right right >> mushrooms like I was in medical school >> mushrooms like I was in medical school >> mushrooms like I was in medical school and I saw two people die of liver and I saw two people die of liver and I saw two people die of liver failure because of foraging for the failure because of foraging for the failure because of foraging for the wrong mushrooms for example So, so and wrong mushrooms for example So, so and wrong mushrooms for example So, so and of course the dose makes the poison, of course the dose makes the poison, of course the dose makes the poison, right? So, you can have low doses of right? So, you can have low doses of right? So, you can have low doses of natural products that can be okay, but natural products that can be okay, but natural products that can be okay, but high doses of nicotine for example can high doses of nicotine for example can high doses of nicotine for example can kill somebody, right? And so on the kill somebody, right? And so on the kill somebody, right? And so on the other side of things, synthetic other side of things, synthetic other side of things, synthetic argument, not everything synthetic is argument, not everything synthetic is argument, not everything synthetic is bad for us is what it comes down to. We bad for us is what it comes down to. We bad for us is what it comes down to. We live in synthetic worlds. We have lots live in synthetic worlds. We have lots live in synthetic worlds. We have lots of synthetic things all around us, of synthetic things all around us, of synthetic things all around us, right? Um my son when he was four, he right? Um my son when he was four, he right? Um my son when he was four, he had a tracking cellulitis or a skin had a tracking cellulitis or a skin had a tracking cellulitis or a skin infection up his leg and I was looking infection up his leg and I was looking infection up his leg and I was looking at it go up his leg in front of me and at it go up his leg in front of me and at it go up his leg in front of me and so I took him to the hospital and I got so I took him to the hospital and I got so I took him to the hospital and I got him antibiotics which are synthetic. him antibiotics which are synthetic. him antibiotics which are synthetic. Okay? And if you're taking insulin right Okay? And if you're taking insulin right Okay? And if you're taking insulin right now as a diabetic, if you have type 1 now as a diabetic, if you have type 1 now as a diabetic, if you have type 1 diabetes or type two, it's a synthetic diabetes or type two, it's a synthetic diabetes or type two, it's a synthetic ingredient. It's not from a pig anymore, ingredient. It's not from a pig anymore, ingredient. It's not from a pig anymore, right? And so there are reasons why we right? And so there are reasons why we right? And so there are reasons why we need synthetic things. And I think need synthetic things. And I think need synthetic things. And I think methylene boo falls into this category methylene boo falls into this category methylene boo falls into this category where where where >> it's a synthetic >> it's a synthetic >> it's a synthetic >> compound that can help so much, >> compound that can help so much, >> compound that can help so much, especially in the short term. And then I especially in the short term. And then I especially in the short term. And then I think over the long term, as you get think over the long term, as you get think over the long term, as you get more optimized, you don't need it as more optimized, you don't need it as more optimized, you don't need it as much. much. much. >> And do you use it in conjunction with >> And do you use it in conjunction with >> And do you use it in conjunction with other mitochondrial support? So in other mitochondrial support? So in other mitochondrial support? So in functional medicine we talked about functional medicine we talked about functional medicine we talked about CoQ10 and creatine and carnitine and CoQ10 and creatine and carnitine and CoQ10 and creatine and carnitine and >> pic acid and ccysteine and rioflavin and >> pic acid and ccysteine and rioflavin and >> pic acid and ccysteine and rioflavin and you know all you know magnesium you know all you know magnesium you know all you know magnesium potassium aspartate all these wonderful potassium aspartate all these wonderful potassium aspartate all these wonderful yes the ribos that can be supportive and yes the ribos that can be supportive and yes the ribos that can be supportive and I've used them in my practice to great I've used them in my practice to great I've used them in my practice to great benefit often you know together with you benefit often you know together with you benefit often you know together with you know think even things like heart know think even things like heart know think even things like heart failure failure failure >> of course >> of course >> of course >> but um do you have to use them in >> but um do you have to use them in >> but um do you have to use them in conjunction with methylene blue or not conjunction with methylene blue or not conjunction with methylene blue or not as much as much as much >> it works better when it's being used in >> it works better when it's being used in >> it works better when it's being used in more of a synergistic mutual way as you more of a synergistic mutual way as you more of a synergistic mutual way as you just described Because not only so just described Because not only so just described Because not only so methane blue what it's going to do is methane blue what it's going to do is methane blue what it's going to do is it's going to increase metabolic rate it's going to increase metabolic rate it's going to increase metabolic rate because it's going to increase the because it's going to increase the because it's going to increase the amount of energy you're making. So low amount of energy you're making. So low amount of energy you're making. So low doses are very supportive. They don't doses are very supportive. They don't doses are very supportive. They don't cause a huge amount of stress cause a huge amount of stress cause a huge amount of stress >> but it is much better to have it as a >> but it is much better to have it as a >> but it is much better to have it as a full ecosystem that you're creating in full ecosystem that you're creating in full ecosystem that you're creating in the mitochondria. So you're grading all the mitochondria. So you're grading all the mitochondria. So you're grading all the substrate meaning you have the the substrate meaning you have the the substrate meaning you have the capacity from vitamins, minerals, capacity from vitamins, minerals, capacity from vitamins, minerals, nutrients like all the things that you nutrients like all the things that you nutrients like all the things that you just mentioned to support mitochondrial just mentioned to support mitochondrial just mentioned to support mitochondrial function and use the methylene blue. function and use the methylene blue. function and use the methylene blue. It's like a supercharge like because the It's like a supercharge like because the It's like a supercharge like because the things you mentioned do a great job with things you mentioned do a great job with things you mentioned do a great job with mitochondrial function but it takes time mitochondrial function but it takes time mitochondrial function but it takes time for all of those to work whereas you for all of those to work whereas you for all of those to work whereas you give some methylene blue in the system give some methylene blue in the system give some methylene blue in the system within about 3 days once you find the within about 3 days once you find the within about 3 days once you find the right dose you will feel a difference right dose you will feel a difference right dose you will feel a difference it's not something that happens 30 days it's not something that happens 30 days it's not something that happens 30 days or a month later which can happen with or a month later which can happen with or a month later which can happen with many of the things that you mentioned many of the things that you mentioned many of the things that you mentioned which I love and I use in my clinical which I love and I use in my clinical which I love and I use in my clinical practice too and they're so supportive practice too and they're so supportive practice too and they're so supportive and necessary but what methane blue can and necessary but what methane blue can and necessary but what methane blue can do is in that short term give you the do is in that short term give you the do is in that short term give you the boost that you need and so that you boost that you need and so that you boost that you need and so that you start feeling the difference much sooner start feeling the difference much sooner start feeling the difference much sooner I recommend magnesium to most of my I recommend magnesium to most of my I recommend magnesium to most of my patients and for good reason. It's patients and for good reason. It's patients and for good reason. It's involved in hundreds of biochemical involved in hundreds of biochemical involved in hundreds of biochemical reactions in the body, including reactions in the body, including reactions in the body, including regulating the nervous system, regulating the nervous system, regulating the nervous system, supporting muscle recovery, and helping supporting muscle recovery, and helping supporting muscle recovery, and helping your body transition to a restful sleep. your body transition to a restful sleep. your body transition to a restful sleep. Now, what's interesting is that newer Now, what's interesting is that newer Now, what's interesting is that newer research is starting to look at how research is starting to look at how research is starting to look at how certain forms of magnesium may support certain forms of magnesium may support certain forms of magnesium may support brain health and sleep quality. Now, one brain health and sleep quality. Now, one brain health and sleep quality. Now, one randomized clinical study, adults who randomized clinical study, adults who randomized clinical study, adults who took a brain available form of magnesium took a brain available form of magnesium took a brain available form of magnesium reported improvements in sleep quality reported improvements in sleep quality reported improvements in sleep quality and daytime functioning compared to and daytime functioning compared to and daytime functioning compared to placebo. Now, magnesium is one of the placebo. Now, magnesium is one of the placebo. Now, magnesium is one of the most common nutrient deficiencies I see. most common nutrient deficiencies I see. most common nutrient deficiencies I see. And low levels can contribute to stress, And low levels can contribute to stress, And low levels can contribute to stress, poor sleep, muscle tension, and low poor sleep, muscle tension, and low poor sleep, muscle tension, and low energy. And the challenge is that most energy. And the challenge is that most energy. And the challenge is that most magnesium supplements only contain one magnesium supplements only contain one magnesium supplements only contain one or two forms, and they're not always or two forms, and they're not always or two forms, and they're not always well absorbed. And that's why I well absorbed. And that's why I well absorbed. And that's why I recommend Magnesium Breakthrough by recommend Magnesium Breakthrough by recommend Magnesium Breakthrough by Boptimizers. It's a full spectrum Boptimizers. It's a full spectrum Boptimizers. It's a full spectrum formula that includes seven different formula that includes seven different formula that includes seven different forms of magnesium designed to support forms of magnesium designed to support forms of magnesium designed to support your brain, your muscles, your stress your brain, your muscles, your stress your brain, your muscles, your stress response, and your sleep. I take it as response, and your sleep. I take it as response, and your sleep. I take it as part of my evening routine. Try it today part of my evening routine. Try it today part of my evening routine. Try it today and go to biopimizers.com/heimman and go to biopimizers.com/heimman and go to biopimizers.com/heimman and use the codeman at checkout to save and use the codeman at checkout to save and use the codeman at checkout to save 15% off your order. That's bio pt i m i 15% off your order. That's bio pt i m i 15% off your order. That's bio pt i m i z.com/heimman z.com/heimman z.com/heimman and use the codeman. As a doctor, one of and use the codeman. As a doctor, one of and use the codeman. As a doctor, one of the questions I get all the time is how the questions I get all the time is how the questions I get all the time is how bad is alcohol for me really. Now, many bad is alcohol for me really. Now, many bad is alcohol for me really. Now, many people reach for a drink at the end of people reach for a drink at the end of people reach for a drink at the end of the day to unwind or to feel social, and the day to unwind or to feel social, and the day to unwind or to feel social, and it works in the moment. But even it works in the moment. But even it works in the moment. But even moderate alcohol, as little as one moderate alcohol, as little as one moderate alcohol, as little as one drink, can disrupt sleep. It can leave drink, can disrupt sleep. It can leave drink, can disrupt sleep. It can leave you groggy the next morning, and it puts you groggy the next morning, and it puts you groggy the next morning, and it puts stress on your body in ways most people stress on your body in ways most people stress on your body in ways most people don't realize. Plus, alcohol is don't realize. Plus, alcohol is don't realize. Plus, alcohol is classified by the World Health classified by the World Health classified by the World Health Organization as a group one carcinogen, Organization as a group one carcinogen, Organization as a group one carcinogen, meaning there's strong evidence linking meaning there's strong evidence linking meaning there's strong evidence linking it to certain cancers, including breast it to certain cancers, including breast it to certain cancers, including breast and colon cancer. So, while an and colon cancer. So, while an and colon cancer. So, while an occasional drink isn't catastrophic, occasional drink isn't catastrophic, occasional drink isn't catastrophic, alcohol isn't actually a healthpromoting alcohol isn't actually a healthpromoting alcohol isn't actually a healthpromoting substance. And if what you're really substance. And if what you're really substance. And if what you're really looking for is relaxation, connection, looking for is relaxation, connection, looking for is relaxation, connection, or that subtle eating lift, is there a or that subtle eating lift, is there a or that subtle eating lift, is there a smarter, gentler way to get it? Well, smarter, gentler way to get it? Well, smarter, gentler way to get it? Well, yes. That's where Vesper comes in from yes. That's where Vesper comes in from yes. That's where Vesper comes in from Peak. Vesper is a non-alcoholic Peak. Vesper is a non-alcoholic Peak. Vesper is a non-alcoholic adaptogenic apparat designed to give you adaptogenic apparat designed to give you adaptogenic apparat designed to give you a mindful alternative to your usual a mindful alternative to your usual a mindful alternative to your usual drink without the next day sleep drink without the next day sleep drink without the next day sleep disruption or the next day brain fog. disruption or the next day brain fog. disruption or the next day brain fog. Ingredients like eltheanine and lemon Ingredients like eltheanine and lemon Ingredients like eltheanine and lemon balm help your body relax while the balm help your body relax while the balm help your body relax while the gentin root adds a subtle uplifting gentin root adds a subtle uplifting gentin root adds a subtle uplifting effect. You feel calm, bright, and effect. You feel calm, bright, and effect. You feel calm, bright, and present, not sedated. I've been paying present, not sedated. I've been paying present, not sedated. I've been paying close attention to this category, and close attention to this category, and close attention to this category, and Vesper is the most thoughtfully Vesper is the most thoughtfully Vesper is the most thoughtfully formulated option I've come across. If formulated option I've come across. If formulated option I've come across. If you're ready to rethink your eating you're ready to rethink your eating you're ready to rethink your eating ritual, Vesper is a thoughtful, ritual, Vesper is a thoughtful, ritual, Vesper is a thoughtful, healthier option. And get up to 20% off healthier option. And get up to 20% off healthier option. And get up to 20% off for life at peak.com/heimman. for life at peak.com/heimman. for life at peak.com/heimman. That's piqlife.com/heimman. So is this the most important tool for So is this the most important tool for getting out of this sympathetic spell of getting out of this sympathetic spell of getting out of this sympathetic spell of doom? doom? doom? >> I found it's the fastest tool to be able >> I found it's the fastest tool to be able >> I found it's the fastest tool to be able to do it from a mitochondrial to do it from a mitochondrial to do it from a mitochondrial perspective, right? Because you want to perspective, right? Because you want to perspective, right? Because you want to be able to support the mitochondria to be able to support the mitochondria to be able to support the mitochondria to help it relax. And a good example of help it relax. And a good example of help it relax. And a good example of this this this >> and it's okay to take it every day. >> and it's okay to take it every day. >> and it's okay to take it every day. >> So in the beginning, yeah, as long as >> So in the beginning, yeah, as long as >> So in the beginning, yeah, as long as you're keeping the dose low, my sense of you're keeping the dose low, my sense of you're keeping the dose low, my sense of this is that this is that this is that >> what does a dose low mean? >> what does a dose low mean? >> what does a dose low mean? >> Right. So usually >> Right. So usually >> Right. So usually >> milligram amount. >> milligram amount. >> milligram amount. >> So typically milligram dose that I find >> So typically milligram dose that I find >> So typically milligram dose that I find that's really great for the mitochondria that's really great for the mitochondria that's really great for the mitochondria is somewhere between 8 to about 25 is somewhere between 8 to about 25 is somewhere between 8 to about 25 milligrams a day. If you're keeping the milligrams a day. If you're keeping the milligrams a day. If you're keeping the dose less than 30 milligrams per day, dose less than 30 milligrams per day, dose less than 30 milligrams per day, you don't even have to take a day off you don't even have to take a day off you don't even have to take a day off and you can take it every day. If you're and you can take it every day. If you're and you can take it every day. If you're giving if you're taking above 70 or 80 giving if you're taking above 70 or 80 giving if you're taking above 70 or 80 or 100 milligrams of methylene blue, or 100 milligrams of methylene blue, or 100 milligrams of methylene blue, then you do need to take more days off. then you do need to take more days off. then you do need to take more days off. So, the thing about it, methane blue So, the thing about it, methane blue So, the thing about it, methane blue kind of has this sort of biodal kind of has this sort of biodal kind of has this sort of biodal capacity. What I mean by that is like capacity. What I mean by that is like capacity. What I mean by that is like low doses of it around what I just low doses of it around what I just low doses of it around what I just described as as a range. Fantastic described as as a range. Fantastic described as as a range. Fantastic mitochondrial function. Sometimes a mitochondrial function. Sometimes a mitochondrial function. Sometimes a little bit higher than that. Um but up little bit higher than that. Um but up little bit higher than that. Um but up to when you get to about a milligram per to when you get to about a milligram per to when you get to about a milligram per kilogram which is around 50 to 70 kilogram which is around 50 to 70 kilogram which is around 50 to 70 milligrams of methylene blue and above. milligrams of methylene blue and above. milligrams of methylene blue and above. What happens then is it becomes more of What happens then is it becomes more of What happens then is it becomes more of an anti-infective actually it's a an anti-infective actually it's a an anti-infective actually it's a fantastic antimicrobial at higher doses fantastic antimicrobial at higher doses fantastic antimicrobial at higher doses and um it does that because it it and um it does that because it it and um it does that because it it produces something in the body called produces something in the body called produces something in the body called hydrogen peroxide and hydrogen peroxide hydrogen peroxide and hydrogen peroxide hydrogen peroxide and hydrogen peroxide you know you can buy at the store. you know you can buy at the store. you know you can buy at the store. >> That's why it's actually what your white >> That's why it's actually what your white >> That's why it's actually what your white blood cells produce to kill infections. blood cells produce to kill infections. blood cells produce to kill infections. >> Exactly. And so what methane blue does >> Exactly. And so what methane blue does >> Exactly. And so what methane blue does is it creates more of a hydrogen is it creates more of a hydrogen is it creates more of a hydrogen peroxide capacity and you kill bugs peroxide capacity and you kill bugs peroxide capacity and you kill bugs easier and you also enhance your easier and you also enhance your easier and you also enhance your antioxidant systems if you have the antioxidant systems if you have the antioxidant systems if you have the capacity. And that's the key. And that's capacity. And that's the key. And that's capacity. And that's the key. And that's why if you have an acute infection, I why if you have an acute infection, I why if you have an acute infection, I use it all the time at high doses. But use it all the time at high doses. But use it all the time at high doses. But if you have a chronic infection, chronic if you have a chronic infection, chronic if you have a chronic infection, chronic lime, chronic mold, I use it at the lime, chronic mold, I use it at the lime, chronic mold, I use it at the higher doses, but I ramp them up. I higher doses, but I ramp them up. I higher doses, but I ramp them up. I don't start. Yes. Because you're because don't start. Yes. Because you're because don't start. Yes. Because you're because if you give somebody a high dose of if you give somebody a high dose of if you give somebody a high dose of methylene blue right off the gate and methylene blue right off the gate and methylene blue right off the gate and they have chronic lime, they're not they have chronic lime, they're not they have chronic lime, they're not going to feel good if you give them 50 going to feel good if you give them 50 going to feel good if you give them 50 or 100 milligrams right away. So slowly or 100 milligrams right away. So slowly or 100 milligrams right away. So slowly increasing their dose mitochondrial increasing their dose mitochondrial increasing their dose mitochondrial support and then higher doses can be support and then higher doses can be support and then higher doses can be fantastically effective for chronic fantastically effective for chronic fantastically effective for chronic lime, for chronic mold, for even people lime, for chronic mold, for even people lime, for chronic mold, for even people with spike protein. I've seen some with spike protein. I've seen some with spike protein. I've seen some interesting things as well. And also, interesting things as well. And also, interesting things as well. And also, you know, it's just as a result of that, you know, it's just as a result of that, you know, it's just as a result of that, even viral infections as well. I've seen even viral infections as well. I've seen even viral infections as well. I've seen some really interesting things. But the some really interesting things. But the some really interesting things. But the majority of people are going to using majority of people are going to using majority of people are going to using lower doses for mitochondrial function. lower doses for mitochondrial function. lower doses for mitochondrial function. That being said, some people have these That being said, some people have these That being said, some people have these chronic infections that are causing chronic infections that are causing chronic infections that are causing significant, you know, infection or sign significant, you know, infection or sign significant, you know, infection or sign significant mitochondrial dysfunction. significant mitochondrial dysfunction. significant mitochondrial dysfunction. But I was gonna say I was gonna tell a But I was gonna say I was gonna tell a But I was gonna say I was gonna tell a patient a story about a friend of mine. patient a story about a friend of mine. patient a story about a friend of mine. He's a colleague. He's like, doc, I've He's a colleague. He's like, doc, I've He's a colleague. He's like, doc, I've had anxiety for, you know, my whole had anxiety for, you know, my whole had anxiety for, you know, my whole life. I started taking methylene blue life. I started taking methylene blue life. I started taking methylene blue and it's gone. and it's gone. and it's gone. >> Wow. >> Wow. >> Wow. >> You ask, well, why is that the case? >> You ask, well, why is that the case? >> You ask, well, why is that the case? Right? Is that because we changed his Right? Is that because we changed his Right? Is that because we changed his neurochemical stuff? No, it's because we neurochemical stuff? No, it's because we neurochemical stuff? No, it's because we gave him significant mitochondrial gave him significant mitochondrial gave him significant mitochondrial support immediately. And then he's like, support immediately. And then he's like, support immediately. And then he's like, I've never felt this good. Like what did I've never felt this good. Like what did I've never felt this good. Like what did And as a result of having enough And as a result of having enough And as a result of having enough mitochondrial support, his system mitochondrial support, his system mitochondrial support, his system started being able to unclench itself. started being able to unclench itself. started being able to unclench itself. >> Yeah. And because now you're making >> Yeah. And because now you're making >> Yeah. And because now you're making enough energy and now the system can enough energy and now the system can enough energy and now the system can start healing. start healing. start healing. >> Um and I found my methylene blue at >> Um and I found my methylene blue at >> Um and I found my methylene blue at these low doses to be fantastically these low doses to be fantastically these low doses to be fantastically effective, Mark. And and I haven't and effective, Mark. And and I haven't and effective, Mark. And and I haven't and initially I was very skeptical, you initially I was very skeptical, you initially I was very skeptical, you know, because I was like this is a know, because I was like this is a know, because I was like this is a compound that doesn't come from the compound that doesn't come from the compound that doesn't come from the ground and my dad's a chiropractor for ground and my dad's a chiropractor for ground and my dad's a chiropractor for 45 years. Like in the beginning he was 45 years. Like in the beginning he was 45 years. Like in the beginning he was militantly against western medicine. Um militantly against western medicine. Um militantly against western medicine. Um but over the years he now knows that but over the years he now knows that but over the years he now knows that it's important to use too. Um but so I it's important to use too. Um but so I it's important to use too. Um but so I was blown away the first couple years was blown away the first couple years was blown away the first couple years when we started using it. people. I had when we started using it. people. I had when we started using it. people. I had this we had this one lady with mild this we had this one lady with mild this we had this one lady with mild cognitive impairment. She started cognitive impairment. She started cognitive impairment. She started telling stories about her childhood that telling stories about her childhood that telling stories about her childhood that nobody in her family had ever heard of nobody in her family had ever heard of nobody in her family had ever heard of before. Her brain came back online. I before. Her brain came back online. I before. Her brain came back online. I had another lady that had chronic mold, had another lady that had chronic mold, had another lady that had chronic mold, done all the remediation in her house, done all the remediation in her house, done all the remediation in her house, in her body, still felt terrible, in her body, still felt terrible, in her body, still felt terrible, started giving her some methylene blue. started giving her some methylene blue. started giving her some methylene blue. She was back to work in two weeks. It She was back to work in two weeks. It She was back to work in two weeks. It was crazy. And then I I had another lady was crazy. And then I I had another lady was crazy. And then I I had another lady with chronic ankylosing spondylitis, with chronic ankylosing spondylitis, with chronic ankylosing spondylitis, like severe pain disorder um in the like severe pain disorder um in the like severe pain disorder um in the back, inflammatory issues. Nothing had back, inflammatory issues. Nothing had back, inflammatory issues. Nothing had ever worked. She started taking ever worked. She started taking ever worked. She started taking methylene blue and her pain just went methylene blue and her pain just went methylene blue and her pain just went away. And I was like, this is back in away. And I was like, this is back in away. And I was like, this is back in 2020. So, you know, we were the first 2020. So, you know, we were the first 2020. So, you know, we were the first people to really pioneer this back then people to really pioneer this back then people to really pioneer this back then in 2020 at the company at our company. in 2020 at the company at our company. in 2020 at the company at our company. And so, we've seen gigantic amounts of And so, we've seen gigantic amounts of And so, we've seen gigantic amounts of of anecdotal data. And then there's of anecdotal data. And then there's of anecdotal data. And then there's researchers that have been doing this researchers that have been doing this researchers that have been doing this and showing that these models of and showing that these models of and showing that these models of Alzheimer's, models of Parkinson's, you Alzheimer's, models of Parkinson's, you Alzheimer's, models of Parkinson's, you know, others looking at in traumatic know, others looking at in traumatic know, others looking at in traumatic brain injury, looking at it in stroke. brain injury, looking at it in stroke. brain injury, looking at it in stroke. And so it's just it's a fantastic And so it's just it's a fantastic And so it's just it's a fantastic compound that, you know, has gotten more compound that, you know, has gotten more compound that, you know, has gotten more popular over the last couple years, popular over the last couple years, popular over the last couple years, which is great. But understanding what which is great. But understanding what which is great. But understanding what you're doing like dosing wise and making you're doing like dosing wise and making you're doing like dosing wise and making sure you're getting good quality stuff sure you're getting good quality stuff sure you're getting good quality stuff is absolutely essential. Like the stuff is absolutely essential. Like the stuff is absolutely essential. Like the stuff on Amazon is garbage mostly. Most on Amazon is garbage mostly. Most on Amazon is garbage mostly. Most liquids out there are not as potent. liquids out there are not as potent. liquids out there are not as potent. Even if it says it on the label, it's, Even if it says it on the label, it's, Even if it says it on the label, it's, you know, it's a huge deal. And so I'm you know, it's a huge deal. And so I'm you know, it's a huge deal. And so I'm very much a proponent of using it, but very much a proponent of using it, but very much a proponent of using it, but using the right company stuff, the right using the right company stuff, the right using the right company stuff, the right products and the right dosing is products and the right dosing is products and the right dosing is absolutely. absolutely. absolutely. >> And you know, just to be transparent, >> And you know, just to be transparent, >> And you know, just to be transparent, you you have created a company you you have created a company you you have created a company prescriptions, which I use, prescriptions, which I use, prescriptions, which I use, >> but but it it it you provide uh >> but but it it it you provide uh >> but but it it it you provide uh methylene blue. methylene blue. methylene blue. >> Yeah. >> Yeah. >> Yeah. >> And and you have different forms of it, >> And and you have different forms of it, >> And and you have different forms of it, but you run through all third party but you run through all third party but you run through all third party testing and make sure it's the right testing and make sure it's the right testing and make sure it's the right dose and dose and dose and >> right >> right >> right >> that there's no contaminants. And so is >> that there's no contaminants. And so is >> that there's no contaminants. And so is is there is there like a is there a is there is there like a is there a is there is there like a is there a method that you've kind of developed method that you've kind of developed method that you've kind of developed that actually you're able to do that? that actually you're able to do that? that actually you're able to do that? >> So at transcriptions which is our >> So at transcriptions which is our >> So at transcriptions which is our company um we decided to make this company um we decided to make this company um we decided to make this company by the way Mark we we actually company by the way Mark we we actually company by the way Mark we we actually evolved it out of a nonprofit evolved it out of a nonprofit evolved it out of a nonprofit organization. So we have a nonprofit organization. So we have a nonprofit organization. So we have a nonprofit called health optimization medicine and called health optimization medicine and called health optimization medicine and practice. You've met Dr. Ted in the past practice. You've met Dr. Ted in the past practice. You've met Dr. Ted in the past who's our founder Dr. Tedoso. And the who's our founder Dr. Tedoso. And the who's our founder Dr. Tedoso. And the idea with the nonprofit was to create an idea with the nonprofit was to create an idea with the nonprofit was to create an ecosystem for practitioners for training ecosystem for practitioners for training ecosystem for practitioners for training and for for learning how to optimize and for for learning how to optimize and for for learning how to optimize health rather than focus on disease and health rather than focus on disease and health rather than focus on disease and very much aligned with functional very much aligned with functional very much aligned with functional medicine. And out of that we birthed the medicine. And out of that we birthed the medicine. And out of that we birthed the transcription company because he wanted transcription company because he wanted transcription company because he wanted to help people right now along that to help people right now along that to help people right now along that path. And transcriptions was the first path. And transcriptions was the first path. And transcriptions was the first company to come out with a commercial company to come out with a commercial company to come out with a commercial product of methylene blue using it in product of methylene blue using it in product of methylene blue using it in 2020. I thought Ted was crazy at the 2020. I thought Ted was crazy at the 2020. I thought Ted was crazy at the time. I'm like what what are people time. I'm like what what are people time. I'm like what what are people going to they're going to want their going to they're going to want their going to they're going to want their urine to be blue because your urine urine to be blue because your urine urine to be blue because your urine >> by the way. Yeah. make sure your urine >> by the way. Yeah. make sure your urine >> by the way. Yeah. make sure your urine green or blue or like you're green or blue or like you're green or blue or like you're >> dying the concentrates in the urine. So >> dying the concentrates in the urine. So >> dying the concentrates in the urine. So you got to you got to watch out for you got to you got to watch out for you got to you got to watch out for that. Um and you have to so you don't that. Um and you have to so you don't that. Um and you have to so you don't >> stain your clothes if you get you got to >> stain your clothes if you get you got to >> stain your clothes if you get you got to be very careful. And so we came out with be very careful. And so we came out with be very careful. And so we came out with the first commercial product in 2020 and the first commercial product in 2020 and the first commercial product in 2020 and I was a little bit hesitant to be honest I was a little bit hesitant to be honest I was a little bit hesitant to be honest because I was like I saw the research it because I was like I saw the research it because I was like I saw the research it was very compelling but then the other was very compelling but then the other was very compelling but then the other issue that I was very hesitant about is issue that I was very hesitant about is issue that I was very hesitant about is that it took us about a year and a half that it took us about a year and a half that it took us about a year and a half longer to launch the company to find a longer to launch the company to find a longer to launch the company to find a good source of methylene blue. even when good source of methylene blue. even when good source of methylene blue. even when it said pharmaceutical grade, USP grade, it said pharmaceutical grade, USP grade, it said pharmaceutical grade, USP grade, it was contaminated with heavy metals or it was contaminated with heavy metals or it was contaminated with heavy metals or it was not as potent as it said on the it was not as potent as it said on the it was not as potent as it said on the label. Um the the challenge is and you label. Um the the challenge is and you label. Um the the challenge is and you know this, you get a a compound from know this, you get a a compound from know this, you get a a compound from another country, we got we get ours from another country, we got we get ours from another country, we got we get ours from Japan and Korea and even China. I mean, Japan and Korea and even China. I mean, Japan and Korea and even China. I mean, it doesn't matter where you're getting it doesn't matter where you're getting it doesn't matter where you're getting it from, you're going to get what's it from, you're going to get what's it from, you're going to get what's called a certificate of analysis with called a certificate of analysis with called a certificate of analysis with your product with with the ingredient your product with with the ingredient your product with with the ingredient itself. That certificate of analysis is itself. That certificate of analysis is itself. That certificate of analysis is technically supposed to be a third party technically supposed to be a third party technically supposed to be a third party assessment of that particular assessment of that particular assessment of that particular ingredient. But can you trust that? ingredient. But can you trust that? ingredient. But can you trust that? That's coming from another country. That's coming from another country. That's coming from another country. >> No. Right. >> No. Right. >> No. Right. is China policing itself. is China policing itself. is China policing itself. >> I'm not even throwing China under the >> I'm not even throwing China under the >> I'm not even throwing China under the bus, any any other country, right? And bus, any any other country, right? And bus, any any other country, right? And so what we do, which most companies so what we do, which most companies so what we do, which most companies don't do, unfortunately, you know this don't do, unfortunately, you know this don't do, unfortunately, you know this in the supplement world, even across the in the supplement world, even across the in the supplement world, even across the board, is that we test it again once it board, is that we test it again once it board, is that we test it again once it comes into the United States, with comes into the United States, with comes into the United States, with another independent lab to make sure another independent lab to make sure another independent lab to make sure that it's safe, to make sure that it that it's safe, to make sure that it that it's safe, to make sure that it meets our specifications, and only then meets our specifications, and only then meets our specifications, and only then do we put it in our products, and then do we put it in our products, and then do we put it in our products, and then we test it again, final product, to make we test it again, final product, to make we test it again, final product, to make sure it's the exact amount of milligram sure it's the exact amount of milligram sure it's the exact amount of milligram dosage. And we've tested a lot of things dosage. And we've tested a lot of things dosage. And we've tested a lot of things on the on the market. Um but in the end on the on the market. Um but in the end on the on the market. Um but in the end I didn't get into this to sell methylene I didn't get into this to sell methylene I didn't get into this to sell methylene blue. I get into this because blue. I get into this because blue. I get into this because >> creating patient >> creating patient >> creating patient >> I saw this pattern. >> I saw this pattern. >> I saw this pattern. >> Yeah. >> Yeah. >> Yeah. >> I didn't know I didn't name it. >> I didn't know I didn't name it. >> I didn't know I didn't name it. >> And you can use in conjunction with your >> And you can use in conjunction with your >> And you can use in conjunction with your other areas of expertise like hyperbaric other areas of expertise like hyperbaric other areas of expertise like hyperbaric oxygen red light therapy which can also oxygen red light therapy which can also oxygen red light therapy which can also help modify mitochondrial function. help modify mitochondrial function. help modify mitochondrial function. Right. Right. Right. >> 100%. Yeah. This is not just a zero some >> 100%. Yeah. This is not just a zero some >> 100%. Yeah. This is not just a zero some game. It's not like one thing. What I game. It's not like one thing. What I game. It's not like one thing. What I find with methane blue it's just a find with methane blue it's just a find with methane blue it's just a fantastic supercharger accelerator fantastic supercharger accelerator fantastic supercharger accelerator bridge for our patients that are just bridge for our patients that are just bridge for our patients that are just stuck and then all of a sudden we stuck and then all of a sudden we stuck and then all of a sudden we unstick them. they could become unstuck, unstick them. they could become unstuck, unstick them. they could become unstuck, I guess. And then we can actually let I guess. And then we can actually let I guess. And then we can actually let them finally heal, finally maximize them finally heal, finally maximize them finally heal, finally maximize their potential, because you can't heal their potential, because you can't heal their potential, because you can't heal when your mitochondria is stuck. And you when your mitochondria is stuck. And you when your mitochondria is stuck. And you >> I agree. It's it's one of the it's one >> I agree. It's it's one of the it's one >> I agree. It's it's one of the it's one of the sticky issues in functional of the sticky issues in functional of the sticky issues in functional medicine is how do you unbburden medicine is how do you unbburden medicine is how do you unbburden someone's mitochondria? How do you get someone's mitochondria? How do you get someone's mitochondria? How do you get them out of this them out of this them out of this >> cell danger response and this what you >> cell danger response and this what you >> cell danger response and this what you call the sympathetic spiral of doom? So call the sympathetic spiral of doom? So call the sympathetic spiral of doom? So So let's kind of talk a little bit about So let's kind of talk a little bit about So let's kind of talk a little bit about what you call the parasympathetic edge. what you call the parasympathetic edge. what you call the parasympathetic edge. What is that? Why is it important? And What is that? Why is it important? And What is that? Why is it important? And it's, you know, people talk about, you it's, you know, people talk about, you it's, you know, people talk about, you know, pushing hard and just going know, pushing hard and just going know, pushing hard and just going through and, you know, going through the through and, you know, going through the through and, you know, going through the barriers that you feel and kind of barriers that you feel and kind of barriers that you feel and kind of overcoming resistance, but you're saying overcoming resistance, but you're saying overcoming resistance, but you're saying maybe that's not the best way. So, what maybe that's not the best way. So, what maybe that's not the best way. So, what is the par sympathetic edge? is the par sympathetic edge? is the par sympathetic edge? >> So, this is the opposite of the >> So, this is the opposite of the >> So, this is the opposite of the sympathetic spiral. This is the sympathetic spiral. This is the sympathetic spiral. This is the parasympathetic edge. But the deal, I parasympathetic edge. But the deal, I parasympathetic edge. But the deal, I have a friend of mine, he's the only have a friend of mine, he's the only have a friend of mine, he's the only Olympic skier and former wide receiver Olympic skier and former wide receiver Olympic skier and former wide receiver on the Philadelphia Eagles. His name is on the Philadelphia Eagles. His name is on the Philadelphia Eagles. His name is Jeremy. Um, and he told me when he first Jeremy. Um, and he told me when he first Jeremy. Um, and he told me when he first started doing his competitions, he would started doing his competitions, he would started doing his competitions, he would listen to like Metallica and like hard listen to like Metallica and like hard listen to like Metallica and like hard metal, but by the time he was Olympic metal, but by the time he was Olympic metal, but by the time he was Olympic level, he was listening to Mozart and level, he was listening to Mozart and level, he was listening to Mozart and Beethoven. Why? He didn't need his Beethoven. Why? He didn't need his Beethoven. Why? He didn't need his nervous system to be functioning at a nervous system to be functioning at a nervous system to be functioning at a sympathetic level. He needed to drop sympathetic level. He needed to drop sympathetic level. He needed to drop down just a little bit to find that edge down just a little bit to find that edge down just a little bit to find that edge so that he was right in there. And you so that he was right in there. And you so that he was right in there. And you talk about people that are high talk about people that are high talk about people that are high performers, they are not in sympathetic performers, they are not in sympathetic performers, they are not in sympathetic overload. they are just below that in a overload. they are just below that in a overload. they are just below that in a place where they can maintain their place where they can maintain their place where they can maintain their capacity. Navy Seals are are are famous capacity. Navy Seals are are are famous capacity. Navy Seals are are are famous for this, right? They can find ways when for this, right? They can find ways when for this, right? They can find ways when they're in when they're actually in they're in when they're actually in they're in when they're actually in operations. They're not sympathetically operations. They're not sympathetically operations. They're not sympathetically dominant. They've done training so much dominant. They've done training so much dominant. They've done training so much like a Michael Phelps is a great example like a Michael Phelps is a great example like a Michael Phelps is a great example of this too, right? You have trained so of this too, right? You have trained so of this too, right? You have trained so much for every eventuality that nothing much for every eventuality that nothing much for every eventuality that nothing is going to make your nervous system go is going to make your nervous system go is going to make your nervous system go too high because if it goes too high, too high because if it goes too high, too high because if it goes too high, >> we don't we can't function that high. We >> we don't we can't function that high. We >> we don't we can't function that high. We don't do well. And this is where like don't do well. And this is where like don't do well. And this is where like the the classic example is like you have the the classic example is like you have the the classic example is like you have that dream where you're supposed to give that dream where you're supposed to give that dream where you're supposed to give a speech and you can't remember your a speech and you can't remember your a speech and you can't remember your lines because when your sympathetic lines because when your sympathetic lines because when your sympathetic nervous system is so high on such high nervous system is so high on such high nervous system is so high on such high alert you actually lose blood flow to alert you actually lose blood flow to alert you actually lose blood flow to the front of your brain which is where the front of your brain which is where the front of your brain which is where you have what's called your executive you have what's called your executive you have what's called your executive function your capacity to maintain function your capacity to maintain function your capacity to maintain things come bring things from your things come bring things from your things come bring things from your long-term memory like you go blank. You long-term memory like you go blank. You long-term memory like you go blank. You go blank. That's that sympathetic go blank. That's that sympathetic go blank. That's that sympathetic activation. And so we want to have activation. And so we want to have activation. And so we want to have people learn is that when we people learn is that when we people learn is that when we downregulate the nervous system, you're downregulate the nervous system, you're downregulate the nervous system, you're going to function better than you're going to function better than you're going to function better than you're even thinking that you're functioning at even thinking that you're functioning at even thinking that you're functioning at a higher capacity when you're at a higher capacity when you're at a higher capacity when you're at sympathetic dominance. Because when you sympathetic dominance. Because when you sympathetic dominance. Because when you teach people that you can bring people teach people that you can bring people teach people that you can bring people down and have them function at a better down and have them function at a better down and have them function at a better level, it is like night and day. I mean level, it is like night and day. I mean level, it is like night and day. I mean the main a good example of this another the main a good example of this another the main a good example of this another one just to give another example is is one just to give another example is is one just to give another example is is recovery. Like we're now in 2026, people recovery. Like we're now in 2026, people recovery. Like we're now in 2026, people care about recovery, right? But we were care about recovery, right? But we were care about recovery, right? But we were kind of like, oh, but you know, five or kind of like, oh, but you know, five or kind of like, oh, but you know, five or 10 years ago, if you were an athlete in 10 years ago, if you were an athlete in 10 years ago, if you were an athlete in the professional sports, nobody gave a the professional sports, nobody gave a the professional sports, nobody gave a crap about recovery, right? And people crap about recovery, right? And people crap about recovery, right? And people were burning out, they were getting were burning out, they were getting were burning out, they were getting injured and things like that. But now, injured and things like that. But now, injured and things like that. But now, if you focus on knowing you can strength if you focus on knowing you can strength if you focus on knowing you can strength train three times a week at most, and train three times a week at most, and train three times a week at most, and it's better than strength training five it's better than strength training five it's better than strength training five times a week. Why? It's the same deal times a week. Why? It's the same deal times a week. Why? It's the same deal because are you going to exercise because are you going to exercise because are you going to exercise optimally? That is sympathetic. But as optimally? That is sympathetic. But as optimally? That is sympathetic. But as soon as you finish exercise, you need to soon as you finish exercise, you need to soon as you finish exercise, you need to drop yourself down into parasympathetic drop yourself down into parasympathetic drop yourself down into parasympathetic to actually gain muscle and actually to actually gain muscle and actually to actually gain muscle and actually build because you build most of your build because you build most of your build because you build most of your muscle when you're out of the gym muscle when you're out of the gym muscle when you're out of the gym >> because cortisol actually cause you to >> because cortisol actually cause you to >> because cortisol actually cause you to lose muscle, right? lose muscle, right? lose muscle, right? >> Yes. It's it's catabolic. >> Yes. It's it's catabolic. >> Yes. It's it's catabolic. >> Yeah. >> Yeah. >> Yeah. >> But the GABA system and that's the >> But the GABA system and that's the >> But the GABA system and that's the system that is involved in calming down system that is involved in calming down system that is involved in calming down the brain. GABA is your primary the brain. GABA is your primary the brain. GABA is your primary inhibitory neurotransmitter. That is inhibitory neurotransmitter. That is inhibitory neurotransmitter. That is your neurotransmitter that puts the your neurotransmitter that puts the your neurotransmitter that puts the brakes on your firing, calms down your brakes on your firing, calms down your brakes on your firing, calms down your nervous system and it's enhanced when nervous system and it's enhanced when nervous system and it's enhanced when you have increased insulin for example. you have increased insulin for example. you have increased insulin for example. So when after you eat your GABA levels So when after you eat your GABA levels So when after you eat your GABA levels go go up for example. But GABA is go go up for example. But GABA is go go up for example. But GABA is deficient in so many of our p in some deficient in so many of our p in some deficient in so many of our p in some people so many people because of the people so many people because of the people so many people because of the lives that we leave with live with lives that we leave with live with lives that we leave with live with stress all over the place. So GABA stress all over the place. So GABA stress all over the place. So GABA deficiency is actually more associated deficiency is actually more associated deficiency is actually more associated with depression, anxiety, insomnia than with depression, anxiety, insomnia than with depression, anxiety, insomnia than any serotonergic issues that you could any serotonergic issues that you could any serotonergic issues that you could ever imagine. ever imagine. ever imagine. >> But but you say that you're taking GABA >> But but you say that you're taking GABA >> But but you say that you're taking GABA because you can buy GABA supplements because you can buy GABA supplements because you can buy GABA supplements over the counter, over the counter, over the counter, >> right? So GABA as a supplement is not a >> right? So GABA as a supplement is not a >> right? So GABA as a supplement is not a good idea. good idea. good idea. >> Yeah. Yeah. >> Yeah. Yeah. >> Yeah. Yeah. >> But you're saying there's another >> But you're saying there's another >> But you're saying there's another compound that comes from the toxic compound that comes from the toxic compound that comes from the toxic mushroom, the aminium mascaria mushroom. mushroom, the aminium mascaria mushroom. mushroom, the aminium mascaria mushroom. >> Uh which is uh agaren. >> Uh which is uh agaren. >> Uh which is uh agaren. >> Yeah. Agaran. Yeah. Agaran. Yeah. A. >> Yeah. Agaran. Yeah. Agaran. Yeah. A. >> Yeah. Agaran. Yeah. Agaran. Yeah. A. >> Yeah. And so what it comes down to like >> Yeah. And so what it comes down to like >> Yeah. And so what it comes down to like to break it down just briefly. Okay, so to break it down just briefly. Okay, so to break it down just briefly. Okay, so GABA again your breaks of your brain, GABA again your breaks of your brain, GABA again your breaks of your brain, right? If most of us are running around right? If most of us are running around right? If most of us are running around GABA deficient because of the GABA deficient because of the GABA deficient because of the sympathetic activation, the spiral that sympathetic activation, the spiral that sympathetic activation, the spiral that we've been talking about, the challenge we've been talking about, the challenge we've been talking about, the challenge is that if you go to your regular doctor is that if you go to your regular doctor is that if you go to your regular doctor and you say, "I have anxiety, I have and you say, "I have anxiety, I have and you say, "I have anxiety, I have stress, I have depression, they're stress, I have depression, they're stress, I have depression, they're probably going to give you an SSRI, probably going to give you an SSRI, probably going to give you an SSRI, maybe they'll give you a benzo, which maybe they'll give you a benzo, which maybe they'll give you a benzo, which you know they don't want to give you, you know they don't want to give you, you know they don't want to give you, but they might give you a short amount but they might give you a short amount but they might give you a short amount of it." Now, when it comes to benzo and of it." Now, when it comes to benzo and of it." Now, when it comes to benzo and alcohol, alcohol, alcohol, >> benzo like >> benzo like >> benzo like >> Valium, >> Valium, >> Valium, right? So those medications and alcohol, right? So those medications and alcohol, right? So those medications and alcohol, they they all bind to the GABA receptor, they they all bind to the GABA receptor, they they all bind to the GABA receptor, but they vastly deplete GABA in the but they vastly deplete GABA in the but they vastly deplete GABA in the process, giving you more GABA issues process, giving you more GABA issues process, giving you more GABA issues over time and more anxiety, more stress, over time and more anxiety, more stress, over time and more anxiety, more stress, and then you have more tolerance to and then you have more tolerance to and then you have more tolerance to those drugs, you need to take more of those drugs, you need to take more of those drugs, you need to take more of them, etc. And so GABA supplements them, etc. And so GABA supplements them, etc. And so GABA supplements sounds like a good idea, right? But the sounds like a good idea, right? But the sounds like a good idea, right? But the problem with the GABA supplement is that problem with the GABA supplement is that problem with the GABA supplement is that GABA is too big of a molecule to get GABA is too big of a molecule to get GABA is too big of a molecule to get into the brain. into the brain. into the brain. >> If you take GABA and it works for you, >> If you take GABA and it works for you, >> If you take GABA and it works for you, >> you have a leaky brain. leaky brain, >> you have a leaky brain. leaky brain, >> you have a leaky brain. leaky brain, meaning that your blood brain barrier is meaning that your blood brain barrier is meaning that your blood brain barrier is not doing what it's supposed to, keeping not doing what it's supposed to, keeping not doing what it's supposed to, keeping things out. And so, well, what do you things out. And so, well, what do you things out. And so, well, what do you really have there? Often times, you have really have there? Often times, you have really have there? Often times, you have a leaky gut, as you you know. So, if you a leaky gut, as you you know. So, if you a leaky gut, as you you know. So, if you optimize the gut, I've had patients like optimize the gut, I've had patients like optimize the gut, I've had patients like this where GABA works for them this where GABA works for them this where GABA works for them beautifully. They feel nice and calm and beautifully. They feel nice and calm and beautifully. They feel nice and calm and relaxed. relaxed. relaxed. We optimize their gut, seal it up, GABA We optimize their gut, seal it up, GABA We optimize their gut, seal it up, GABA supplements stop working. And when I supplements stop working. And when I supplements stop working. And when I first started talking about this a first started talking about this a first started talking about this a number of years ago, I had a number of number of years ago, I had a number of number of years ago, I had a number of clinicians that came up to me and said, clinicians that came up to me and said, clinicians that came up to me and said, "Gaba supplements, if they work for my "Gaba supplements, if they work for my "Gaba supplements, if they work for my patients, it's diagnostic they have a patients, it's diagnostic they have a patients, it's diagnostic they have a leaky brain." And I was like, "This is leaky brain." And I was like, "This is leaky brain." And I was like, "This is interesting." And I I started learning interesting." And I I started learning interesting." And I I started learning more about it and seeing it in my own more about it and seeing it in my own more about it and seeing it in my own clinical practice. When you optimize the clinical practice. When you optimize the clinical practice. When you optimize the gut, which you and I do in practice all gut, which you and I do in practice all gut, which you and I do in practice all the time, the brain gets better. So GABA the time, the brain gets better. So GABA the time, the brain gets better. So GABA supplements don't work. If they do work, supplements don't work. If they do work, supplements don't work. If they do work, go see a practitioner. go see a practitioner. go see a practitioner. >> But there's something else you can take, >> But there's something else you can take, >> But there's something else you can take, which is from the mushroom. which is from the mushroom. which is from the mushroom. >> Right. Right. The mushroom has So the >> Right. Right. The mushroom has So the >> Right. Right. The mushroom has So the ammonita mushroom has a very cool ammonita mushroom has a very cool ammonita mushroom has a very cool compound called agarin or or agaren. And compound called agarin or or agaren. And compound called agarin or or agaren. And it's a long acting molecule that works it's a long acting molecule that works it's a long acting molecule that works on the GABA receptor binding to where on the GABA receptor binding to where on the GABA receptor binding to where GABA would bind. The cool thing about GABA would bind. The cool thing about GABA would bind. The cool thing about the GABA receptor is that there's a the GABA receptor is that there's a the GABA receptor is that there's a there's it's five subunit receptor. Not there's it's five subunit receptor. Not there's it's five subunit receptor. Not getting too technical, but you have a getting too technical, but you have a getting too technical, but you have a place where GABA binds itself and then place where GABA binds itself and then place where GABA binds itself and then you have separate sites called, you you have separate sites called, you you have separate sites called, you know, separate sites or alsteric sites know, separate sites or alsteric sites know, separate sites or alsteric sites where other things can bind. Yeah. where other things can bind. Yeah. where other things can bind. Yeah. >> Where aguran binds is where directly >> Where aguran binds is where directly >> Where aguran binds is where directly where GABA would bind. So when you take where GABA would bind. So when you take where GABA would bind. So when you take it, you're not depleting GABA in the it, you're not depleting GABA in the it, you're not depleting GABA in the process. The thing is if you're binding process. The thing is if you're binding process. The thing is if you're binding something on a separate site to the GABA something on a separate site to the GABA something on a separate site to the GABA receptor, say it's cava for example or receptor, say it's cava for example or receptor, say it's cava for example or CBD or CBG or magnolia bark or valyan, CBD or CBG or magnolia bark or valyan, CBD or CBG or magnolia bark or valyan, these are all binding to separate sites these are all binding to separate sites these are all binding to separate sites increasing the amount of GABA to bind. increasing the amount of GABA to bind. increasing the amount of GABA to bind. But if you don't have enough GABA around But if you don't have enough GABA around But if you don't have enough GABA around >> all that's not going to what's going to >> all that's not going to what's going to >> all that's not going to what's going to happen is over time those aren't going happen is over time those aren't going happen is over time those aren't going to work very well for you. They're going to work very well for you. They're going to work very well for you. They're going to stop working. to stop working. to stop working. >> Well, Scott, so this is really >> Well, Scott, so this is really >> Well, Scott, so this is really fascinating stuff and I think that uh fascinating stuff and I think that uh fascinating stuff and I think that uh you know getting a parasympathetic edge you know getting a parasympathetic edge you know getting a parasympathetic edge is key. ending the sympathetic spy doom is key. ending the sympathetic spy doom is key. ending the sympathetic spy doom is key. is key. is key. >> How do how do you kind of support people >> How do how do you kind of support people >> How do how do you kind of support people to kind of maintain they've sort of to kind of maintain they've sort of to kind of maintain they've sort of broken the cycle a little bit you you broken the cycle a little bit you you broken the cycle a little bit you you and we're we're going to refer you to and we're we're going to refer you to and we're we're going to refer you to resources. I know you've written a lot resources. I know you've written a lot resources. I know you've written a lot about this and I want to ask you s where about this and I want to ask you s where about this and I want to ask you s where people can find out more information but people can find out more information but people can find out more information but how do you maintain a more stable state how do you maintain a more stable state how do you maintain a more stable state rather than keep falling into the rather than keep falling into the rather than keep falling into the sympathetic spiral of doom. sympathetic spiral of doom. sympathetic spiral of doom. >> Yeah, I think the first place is to know >> Yeah, I think the first place is to know >> Yeah, I think the first place is to know what it feels like to not be in that what it feels like to not be in that what it feels like to not be in that state, right? is when you know that the state, right? is when you know that the state, right? is when you know that the system is now calmed down, you're going system is now calmed down, you're going system is now calmed down, you're going to feel better. You may not feel 100% to feel better. You may not feel 100% to feel better. You may not feel 100% better right away because you still need better right away because you still need better right away because you still need a lot of long-term support. You need a lot of long-term support. You need a lot of long-term support. You need support with, you know, your vitamins, support with, you know, your vitamins, support with, you know, your vitamins, your minerals, your nutrients, your your minerals, your nutrients, your your minerals, your nutrients, your diet. These things can take time, as you diet. These things can take time, as you diet. These things can take time, as you know, and be difficult and then you fall know, and be difficult and then you fall know, and be difficult and then you fall off the wagon, come back up and things off the wagon, come back up and things off the wagon, come back up and things like that. So, but I think what it comes like that. So, but I think what it comes like that. So, but I think what it comes down to for me is that you need to have down to for me is that you need to have down to for me is that you need to have short-term short-term short-term >> ways to intervene, right? short-term way >> ways to intervene, right? short-term way >> ways to intervene, right? short-term way for me is methylene blue is just a great for me is methylene blue is just a great for me is methylene blue is just a great capacity enhancer in the mitochondria. capacity enhancer in the mitochondria. capacity enhancer in the mitochondria. Optimizing the GABA system can be great Optimizing the GABA system can be great Optimizing the GABA system can be great and transcriptions does have some and transcriptions does have some and transcriptions does have some products there. We have something like products there. We have something like products there. We have something like called Trocom and and Troy. They can be called Trocom and and Troy. They can be called Trocom and and Troy. They can be helpful. You don't have to go product. helpful. You don't have to go product. helpful. You don't have to go product. You can also learn how to meditate and You can also learn how to meditate and You can also learn how to meditate and do breath work and start taking more do breath work and start taking more do breath work and start taking more walks in nature, get better sunlight. walks in nature, get better sunlight. walks in nature, get better sunlight. These are all going to be helpful too. These are all going to be helpful too. These are all going to be helpful too. It doesn't matter where people are in It doesn't matter where people are in It doesn't matter where people are in that on their level of capacity to start that on their level of capacity to start that on their level of capacity to start doing something, right? Sometimes it's doing something, right? Sometimes it's doing something, right? Sometimes it's helpful, I found, is to give them helpful, I found, is to give them helpful, I found, is to give them something like something that something like something that something like something that downregulates the nervous system, downregulates the nervous system, downregulates the nervous system, something that that's GABAurgic that something that that's GABAurgic that something that that's GABAurgic that works on the GABA system to give them works on the GABA system to give them works on the GABA system to give them the experience of what it feels like to the experience of what it feels like to the experience of what it feels like to not be in that sympathetic state and not be in that sympathetic state and not be in that sympathetic state and doing it in a very supportive way. So doing it in a very supportive way. So doing it in a very supportive way. So their mitochondria supported typically their mitochondria supported typically their mitochondria supported typically is what I try to do first, as I is what I try to do first, as I is what I try to do first, as I mentioned, mentioned, mentioned, >> and then I'll have give them the >> and then I'll have give them the >> and then I'll have give them the experience. experience. experience. >> You can still get some reactive anxiety >> You can still get some reactive anxiety >> You can still get some reactive anxiety when that happens because you're used to when that happens because you're used to when that happens because you're used to being at a certain level. being at a certain level. being at a certain level. >> Um, so that's short-term. So charge >> Um, so that's short-term. So charge >> Um, so that's short-term. So charge giving people the experience of where giving people the experience of where giving people the experience of where there is. We talk about in meditation there is. We talk about in meditation there is. We talk about in meditation there's no there there but in there's no there there but in there's no there there but in parasympathetic edge there absolutely is parasympathetic edge there absolutely is parasympathetic edge there absolutely is a there there. So knowing what that a there there. So knowing what that a there there. So knowing what that feels like and then you can try to feels like and then you can try to feels like and then you can try to modulate that in various things that modulate that in various things that modulate that in various things that you're doing in your day-to-day life. you're doing in your day-to-day life. you're doing in your day-to-day life. >> Powerful >> Powerful >> Powerful >> and but that's the thing like your >> and but that's the thing like your >> and but that's the thing like your day-to-day life becomes your meditation day-to-day life becomes your meditation day-to-day life becomes your meditation becomes your life, right? You have to becomes your life, right? You have to becomes your life, right? You have to find ways during your day to break down find ways during your day to break down find ways during your day to break down not break down but calm down the system, not break down but calm down the system, not break down but calm down the system, right? Taking more breaks, getting right? Taking more breaks, getting right? Taking more breaks, getting outside in the sunlight. Um, and then outside in the sunlight. Um, and then outside in the sunlight. Um, and then that's more medium-term. Long-term is that's more medium-term. Long-term is that's more medium-term. Long-term is like, okay, why are you so like, okay, why are you so like, okay, why are you so sympathetically activated? Like, we sympathetically activated? Like, we sympathetically activated? Like, we talked about this. Is it external stuff? talked about this. Is it external stuff? talked about this. Is it external stuff? Is it the is the top down? Do you need Is it the is the top down? Do you need Is it the is the top down? Do you need to get out of a bad marriage? Do you to get out of a bad marriage? Do you to get out of a bad marriage? Do you need to sleep in a different room to need to sleep in a different room to need to sleep in a different room to just get a sleep divorce from your just get a sleep divorce from your just get a sleep divorce from your partner? partner? partner? >> I think about 50% of us couples sleep in >> I think about 50% of us couples sleep in >> I think about 50% of us couples sleep in different beds, different rooms. different beds, different rooms. different beds, different rooms. >> This is not it's not a small thing. They >> This is not it's not a small thing. They >> This is not it's not a small thing. They have a more PC word of like sleep union have a more PC word of like sleep union have a more PC word of like sleep union or something like that now instead of or something like that now instead of or something like that now instead of sleep divorce. It make it doesn't sound sleep divorce. It make it doesn't sound sleep divorce. It make it doesn't sound as bad. But if you need to sleep in a as bad. But if you need to sleep in a as bad. But if you need to sleep in a different room so you get better sleep, different room so you get better sleep, different room so you get better sleep, you should. But that can be hard, right? you should. But that can be hard, right? you should. But that can be hard, right? So trauma, you mentioned this as well. So trauma, you mentioned this as well. So trauma, you mentioned this as well. And this is where things become harder, And this is where things become harder, And this is where things become harder, right? This is where your experiences right? This is where your experiences right? This is where your experiences with psychedelics specifically are very with psychedelics specifically are very with psychedelics specifically are very interesting, right? Because like looking interesting, right? Because like looking interesting, right? Because like looking at psychedelics like ketamine and and at psychedelics like ketamine and and at psychedelics like ketamine and and MDMA and it's legal and I gain like you MDMA and it's legal and I gain like you MDMA and it's legal and I gain like you did, right? Like these are huge. I know did, right? Like these are huge. I know did, right? Like these are huge. I know you've already you've spoken openly you've already you've spoken openly you've already you've spoken openly about this which I really commend you on about this which I really commend you on about this which I really commend you on because because because >> I'm very often sending my patients to go >> I'm very often sending my patients to go >> I'm very often sending my patients to go get ketamine with our friend you know get ketamine with our friend you know get ketamine with our friend you know Dave Rabin and and and others that are Dave Rabin and and and others that are Dave Rabin and and and others that are out there that are really good at out there that are really good at out there that are really good at creating a huge neuroplastic response to creating a huge neuroplastic response to creating a huge neuroplastic response to these these medicines and that's where these these medicines and that's where these these medicines and that's where the real healing is going to occur long the real healing is going to occur long the real healing is going to occur long term like we can give the people the term like we can give the people the term like we can give the people the experience of downregulating their experience of downregulating their experience of downregulating their nervous system now we can give them nervous system now we can give them nervous system now we can give them modes of operation on a day-to-day modes of operation on a day-to-day modes of operation on a day-to-day basis. But if there's elephants that are basis. But if there's elephants that are basis. But if there's elephants that are hanging around in the room, those are hanging around in the room, those are hanging around in the room, those are still there, you know, and we have to still there, you know, and we have to still there, you know, and we have to address those. From the mitochondrial address those. From the mitochondrial address those. From the mitochondrial side, it's the same thing, right? We side, it's the same thing, right? We side, it's the same thing, right? We have to address the mercury toxicity. We have to address the mercury toxicity. We have to address the mercury toxicity. We have to address the toxic exposures or have to address the toxic exposures or have to address the toxic exposures or the the the >> practice functional medicine basically. >> practice functional medicine basically. >> practice functional medicine basically. >> Exactly. Yeah. Yes. Exactly. Like that's >> Exactly. Yeah. Yes. Exactly. Like that's >> Exactly. Yeah. Yes. Exactly. Like that's >> works the system. Yeah. >> works the system. Yeah. >> works the system. Yeah. >> You have to be the system is and your >> You have to be the system is and your >> You have to be the system is and your system is fantastic for that, right? system is fantastic for that, right? system is fantastic for that, right? That's what you do. That's what you do. That's what you do. >> Yeah. >> Yeah. >> Yeah. >> And that's what's beautiful. But that >> And that's what's beautiful. But that >> And that's what's beautiful. But that takes longer. takes longer. takes longer. >> Yeah. >> Yeah. >> Yeah. So, can people stand methylene blue long So, can people stand methylene blue long So, can people stand methylene blue long term or is it is it like a maintenance term or is it is it like a maintenance term or is it is it like a maintenance thing? thing? thing? >> What I'd have people typically do is >> What I'd have people typically do is >> What I'd have people typically do is that find your right dose. What I my that find your right dose. What I my that find your right dose. What I my main way of doing that is start off at a main way of doing that is start off at a main way of doing that is start off at a low dose somewhere at four or eight low dose somewhere at four or eight low dose somewhere at four or eight milligrams and which is a quarter or milligrams and which is a quarter or milligrams and which is a quarter or half one of our troies and then increase half one of our troies and then increase half one of our troies and then increase your dose every 3 to 5 days. your dose every 3 to 5 days. your dose every 3 to 5 days. See how you feel at one dose. Take it in See how you feel at one dose. Take it in See how you feel at one dose. Take it in the morning. Typically, the morning. Typically, the morning. Typically, >> one whole troy is is 16. >> one whole troy is is 16. >> one whole troy is is 16. >> Yeah. One whole trophy is 16 then one >> Yeah. One whole trophy is 16 then one >> Yeah. One whole trophy is 16 then one quarter is four milligrams. So take four quarter is four milligrams. So take four quarter is four milligrams. So take four milligrams in the morning. See how you milligrams in the morning. See how you milligrams in the morning. See how you feel. Take it on an empty stomach. You feel. Take it on an empty stomach. You feel. Take it on an empty stomach. You don't have to dissolve in the mouth. don't have to dissolve in the mouth. don't have to dissolve in the mouth. Okay? You can if you like, but your Okay? You can if you like, but your Okay? You can if you like, but your mouth is going to be blue. That's okay, mouth is going to be blue. That's okay, mouth is going to be blue. That's okay, too. It's a little bit works faster up too. It's a little bit works faster up too. It's a little bit works faster up here, but the same amount of my of here, but the same amount of my of here, but the same amount of my of methylene boo is going to get in the methylene boo is going to get in the methylene boo is going to get in the body. See how you feel for about 3 days. body. See how you feel for about 3 days. body. See how you feel for about 3 days. Take it in the morning. Don't feel much, Take it in the morning. Don't feel much, Take it in the morning. Don't feel much, go to 8 milligrams. See how you feel. go to 8 milligrams. See how you feel. go to 8 milligrams. See how you feel. Take it on an empty stomach in the Take it on an empty stomach in the Take it on an empty stomach in the morning. If you don't feel much, go to morning. If you don't feel much, go to morning. If you don't feel much, go to 12. Then go to 16. But somewhere between 12. Then go to 16. But somewhere between 12. Then go to 16. But somewhere between 8 and 16 for most people is when they're 8 and 16 for most people is when they're 8 and 16 for most people is when they're going to start feeling, "Wow, I do have going to start feeling, "Wow, I do have going to start feeling, "Wow, I do have more energy. Wow, my brain's functioning more energy. Wow, my brain's functioning more energy. Wow, my brain's functioning a little bit better. I don't have as a little bit better. I don't have as a little bit better. I don't have as much brain fog. I'm not getting that much brain fog. I'm not getting that much brain fog. I'm not getting that energy dip in the middle of the day. My energy dip in the middle of the day. My energy dip in the middle of the day. My inflammation is better. My even my pain inflammation is better. My even my pain inflammation is better. My even my pain might be better. My mood seems to be might be better. My mood seems to be might be better. My mood seems to be more regulated. You will know and that's more regulated. You will know and that's more regulated. You will know and that's what I find is that and then when you what I find is that and then when you what I find is that and then when you start increasing the dose more from start increasing the dose more from start increasing the dose more from there, you don't typically see as much there, you don't typically see as much there, you don't typically see as much return on your investment. Usually return on your investment. Usually return on your investment. Usually there's like a sweet spot for people and there's like a sweet spot for people and there's like a sweet spot for people and once you find that right dose, how long once you find that right dose, how long once you find that right dose, how long or how often should you take it? Depends or how often should you take it? Depends or how often should you take it? Depends on what you're taking it for. If you're on what you're taking it for. If you're on what you're taking it for. If you're taking it as a bridge, you're kind of taking it as a bridge, you're kind of taking it as a bridge, you're kind of early on in your process. You might need early on in your process. You might need early on in your process. You might need to take it every day. And I have to take it every day. And I have to take it every day. And I have patients that are on it every day for a patients that are on it every day for a patients that are on it every day for a while, but over time the goal is always while, but over time the goal is always while, but over time the goal is always to come on it less or use it less, only to come on it less or use it less, only to come on it less or use it less, only needing it when you only using it when needing it when you only using it when needing it when you only using it when you need it. So for example, when you you need it. So for example, when you you need it. So for example, when you get more optimized, you're still going get more optimized, you're still going get more optimized, you're still going to have mitochondrial stress, you know, to have mitochondrial stress, you know, to have mitochondrial stress, you know, and the question is when do you use it? and the question is when do you use it? and the question is when do you use it? So a good example is when you're So a good example is when you're So a good example is when you're traveling on an airplane. On an traveling on an airplane. On an traveling on an airplane. On an airplane, you're going from about 21% airplane, you're going from about 21% airplane, you're going from about 21% oxygen in the air that you're breathing oxygen in the air that you're breathing oxygen in the air that you're breathing at sea level to about 18% relatively on at sea level to about 18% relatively on at sea level to about 18% relatively on a plane. That's a huge hypoxic stress, a plane. That's a huge hypoxic stress, a plane. That's a huge hypoxic stress, low oxygen stress on an airplane because low oxygen stress on an airplane because low oxygen stress on an airplane because you're pressurized to about 8,000 feet you're pressurized to about 8,000 feet you're pressurized to about 8,000 feet above sea level. The best jet lag hack above sea level. The best jet lag hack above sea level. The best jet lag hack that I've ever found, Mark, is to move that I've ever found, Mark, is to move that I've ever found, Mark, is to move to Colorado because I live at 5,500 ft. to Colorado because I live at 5,500 ft. to Colorado because I live at 5,500 ft. And so when I go on an airplane, it's And so when I go on an airplane, it's And so when I go on an airplane, it's 8,000 ft pressurization. Then I come to 8,000 ft pressurization. Then I come to 8,000 ft pressurization. Then I come to Austin to visit you. I'm at sea level. I Austin to visit you. I'm at sea level. I Austin to visit you. I'm at sea level. I feel great because I've been at I've feel great because I've been at I've feel great because I've been at I've been at altitude for a while. been at altitude for a while. been at altitude for a while. >> And I was just at 8,500 feet in um in >> And I was just at 8,500 feet in um in >> And I was just at 8,500 feet in um in Montana and I felt it. Montana and I felt it. Montana and I felt it. >> You need methylene blue for that, man. >> You need methylene blue for that, man. >> You need methylene blue for that, man. Because then actually what I have is Because then actually what I have is Because then actually what I have is anybody that's coming to visit me, I anybody that's coming to visit me, I anybody that's coming to visit me, I always give them the methane blue before always give them the methane blue before always give them the methane blue before they get on the plane. they get on the plane. they get on the plane. >> And then I was actually with our >> And then I was actually with our >> And then I was actually with our nonprofit Dr. Ted and and Boomer who's nonprofit Dr. Ted and and Boomer who's nonprofit Dr. Ted and and Boomer who's our CEO of Transcriptions and Home. We our CEO of Transcriptions and Home. We our CEO of Transcriptions and Home. We were in Tibet were in Tibet were in Tibet >> and we were at Mount Everest base camp >> and we were at Mount Everest base camp >> and we were at Mount Everest base camp at 17,800 ft. at 17,800 ft. at 17,800 ft. >> 17,000. It was very very high. We didn't >> 17,000. It was very very high. We didn't >> 17,000. It was very very high. We didn't have we had intermittent oxygen. We had have we had intermittent oxygen. We had have we had intermittent oxygen. We had oxygen canisters, but we're using oxygen canisters, but we're using oxygen canisters, but we're using methylene blue. It was gamechanging up. methylene blue. It was gamechanging up. methylene blue. It was gamechanging up. >> That wasn't the only thing we used. We >> That wasn't the only thing we used. We >> That wasn't the only thing we used. We used Diamox and we used used Diamox and we used used Diamox and we used >> I got I got I got pretty significant >> I got I got I got pretty significant >> I got I got I got pretty significant altitude signal. I was in Bolivia. We altitude signal. I was in Bolivia. We altitude signal. I was in Bolivia. We drove right up to 16,000 ft. Like there drove right up to 16,000 ft. Like there drove right up to 16,000 ft. Like there was no climatization and there was a was no climatization and there was a was no climatization and there was a hotel there and my oxygen saturations hotel there and my oxygen saturations hotel there and my oxygen saturations were down in the 70s. were down in the 70s. were down in the 70s. >> I'm sure. Yeah. The ts were low too. We >> I'm sure. Yeah. The ts were low too. We >> I'm sure. Yeah. The ts were low too. We had them on oxygen had them on oxygen had them on oxygen >> but we were using diamox which is a drug >> but we were using diamox which is a drug >> but we were using diamox which is a drug for altitude. We're using Viagra as well for altitude. We're using Viagra as well for altitude. We're using Viagra as well because it helps with nitric oxide and because it helps with nitric oxide and because it helps with nitric oxide and blood flow. And then we're using blood flow. And then we're using blood flow. And then we're using methylene blue. So methylene blue. So methylene blue. So >> as you get more optimized Mark, >> as you get more optimized Mark, >> as you get more optimized Mark, >> you don't need as much and you don't >> you don't need as much and you don't >> you don't need as much and you don't need it as often. And that's but I have need it as often. And that's but I have need it as often. And that's but I have everybody all of my patients have a everybody all of my patients have a everybody all of my patients have a higher strength methylene blue in their higher strength methylene blue in their higher strength methylene blue in their medicine cabinet just in case medicine cabinet just in case medicine cabinet just in case >> which is >> which is >> which is >> like which is which is 50 milligrams in >> like which is which is 50 milligrams in >> like which is which is 50 milligrams in strength. So we have something called strength. So we have something called strength. So we have something called trop plus blue which is available to trop plus blue which is available to trop plus blue which is available to practitioner. So if you're a practitioner. So if you're a practitioner. So if you're a practitioner listening we have a practitioner listening we have a practitioner listening we have a practitioner practitioner practitioner >> and why would you use the 50? >> and why would you use the 50? >> and why would you use the 50? >> So the 50s are great for acute infection >> So the 50s are great for acute infection >> So the 50s are great for acute infection acute stress overall and so I use it for acute stress overall and so I use it for acute stress overall and so I use it for acute infection acute stress. So if acute infection acute stress. So if acute infection acute stress. So if somebody has like a concussion or has a somebody has like a concussion or has a somebody has like a concussion or has a you know acute injury um I give them you know acute injury um I give them you know acute injury um I give them higher doses um higher doses um higher doses um >> for a short period of time. >> for a short period of time. >> for a short period of time. >> Yeah. for a short period of time and >> Yeah. for a short period of time and >> Yeah. for a short period of time and sometimes I combine it with anti sometimes I combine it with anti sometimes I combine it with anti antibiotics. So my mom for example was antibiotics. So my mom for example was antibiotics. So my mom for example was bitten by a lime tick in New York. She's bitten by a lime tick in New York. She's bitten by a lime tick in New York. She's around 70 and so sorry mom I gave away around 70 and so sorry mom I gave away around 70 and so sorry mom I gave away your age but I gave her I gave her your age but I gave her I gave her your age but I gave her I gave her methylene blue about 2 milligrams per methylene blue about 2 milligrams per methylene blue about 2 milligrams per kilogram about 150 milligrams for for 5 kilogram about 150 milligrams for for 5 kilogram about 150 milligrams for for 5 days and she also took doxy at the same days and she also took doxy at the same days and she also took doxy at the same time time time >> we wanted to give her doxy because she's >> we wanted to give her doxy because she's >> we wanted to give her doxy because she's in New York lime ticks are everywhere in New York lime ticks are everywhere in New York lime ticks are everywhere right but her we checked her lime titers right but her we checked her lime titers right but her we checked her lime titers four weeks later they were negative four weeks later they were negative four weeks later they were negative right so and so it's not like it's the right so and so it's not like it's the right so and so it's not like it's the only thing sometimes but it's also being only thing sometimes but it's also being only thing sometimes but it's also being used as monotherapy for urinary tract used as monotherapy for urinary tract used as monotherapy for urinary tract infections as well infections as well infections as well >> at these higher doses so I give higher >> at these higher doses so I give higher >> at these higher doses so I give higher doses That's amazing. doses That's amazing. doses That's amazing. >> Intermittently, but it's the lower doses >> Intermittently, but it's the lower doses >> Intermittently, but it's the lower doses that I use and maintain. So, for me, that I use and maintain. So, for me, that I use and maintain. So, for me, I'll use it about three times a week, I'll use it about three times a week, I'll use it about three times a week, four milligrams every day, every four four milligrams every day, every four four milligrams every day, every four milligrams at a time. Sometimes twice milligrams at a time. Sometimes twice milligrams at a time. Sometimes twice daily. You can dose it in the morning. daily. You can dose it in the morning. daily. You can dose it in the morning. Sometimes I'll dose it again early in Sometimes I'll dose it again early in Sometimes I'll dose it again early in the afternoon as well because it doesn't the afternoon as well because it doesn't the afternoon as well because it doesn't typically keep you up. It's not like typically keep you up. It's not like typically keep you up. It's not like caffeine or a stimulant. It should just caffeine or a stimulant. It should just caffeine or a stimulant. It should just give you more energy. Feel like you can give you more energy. Feel like you can give you more energy. Feel like you can just kind of go, you know? That's the just kind of go, you know? That's the just kind of go, you know? That's the idea. And then when you find that right idea. And then when you find that right idea. And then when you find that right dose, often you'll know it if you're dose, often you'll know it if you're dose, often you'll know it if you're pretty well optimized. You can also use pretty well optimized. You can also use pretty well optimized. You can also use it for endurance. I have guys that use it for endurance. I have guys that use it for endurance. I have guys that use it because it increases aerobic it because it increases aerobic it because it increases aerobic capacity. capacity. capacity. >> Oh, good. Okay. >> Oh, good. Okay. >> Oh, good. Okay. >> So, I have cyclists that use it. I have >> So, I have cyclists that use it. I have >> So, I have cyclists that use it. I have >> a bike trip this summer. I'm going to do >> a bike trip this summer. I'm going to do >> a bike trip this summer. I'm going to do that. that. that. >> Yeah, exactly. And I have ultramarathons >> Yeah, exactly. And I have ultramarathons >> Yeah, exactly. And I have ultramarathons that I use it. I know you've you've used that I use it. I know you've you've used that I use it. I know you've you've used it as well and had some experience as it as well and had some experience as it as well and had some experience as well. well. well. >> This has been such a great conversation. >> This has been such a great conversation. >> This has been such a great conversation. Where can people learn more about your Where can people learn more about your Where can people learn more about your work about the the sympathetic spiral of work about the the sympathetic spiral of work about the the sympathetic spiral of doom or cell danger, all that stuff doom or cell danger, all that stuff doom or cell danger, all that stuff >> a couple different places. And thank you >> a couple different places. And thank you >> a couple different places. And thank you for having me, Mark. Um, so my personal for having me, Mark. Um, so my personal for having me, Mark. Um, so my personal website is my name. It's my name, Dr. website is my name. It's my name, Dr. website is my name. It's my name, Dr. Scott Sher. d r s o tt s h e r r.com. Um Scott Sher. d r s o tt s h e r r.com. Um Scott Sher. d r s o tt s h e r r.com. Um the company that makes some of the the company that makes some of the the company that makes some of the products we've been talking about today products we've been talking about today products we've been talking about today is called Troscriptions. It's the word is called Troscriptions. It's the word is called Troscriptions. It's the word Troy and prescriptions mashed up into Troy and prescriptions mashed up into Troy and prescriptions mashed up into Troscriptions. We are pharmaceutical Troscriptions. We are pharmaceutical Troscriptions. We are pharmaceutical grade. We're physicians that run the grade. We're physicians that run the grade. We're physicians that run the company and we have precision dosing company and we have precision dosing company and we have precision dosing with all of our products. I really care with all of our products. I really care with all of our products. I really care about all of that. So does Dr. Ted. You about all of that. So does Dr. Ted. You about all of that. So does Dr. Ted. You can check it out at prescriptions.com. can check it out at prescriptions.com. can check it out at prescriptions.com. We have Just Blue, which is our pure We have Just Blue, which is our pure We have Just Blue, which is our pure methylene blue. We have something called methylene blue. We have something called methylene blue. We have something called blue cannotine which is a combination blue cannotine which is a combination blue cannotine which is a combination with methylene blue nicotine, caffeine with methylene blue nicotine, caffeine with methylene blue nicotine, caffeine and CBD which is fantastic for focus. and CBD which is fantastic for focus. and CBD which is fantastic for focus. It's more for stimulation but great as a It's more for stimulation but great as a It's more for stimulation but great as a stimulant. Then we have trocom and tro stimulant. Then we have trocom and tro stimulant. Then we have trocom and tro which are more on that GABA side turning which are more on that GABA side turning which are more on that GABA side turning that brain off that GABAurgic side. So that brain off that GABAurgic side. So that brain off that GABAurgic side. So tcom and tro and then we have a whole tcom and tro and then we have a whole tcom and tro and then we have a whole practitioner. practitioner. practitioner. >> Tro is for sleep. >> Tro is for sleep. >> Tro is for sleep. >> Tro is about the most comprehensive >> Tro is about the most comprehensive >> Tro is about the most comprehensive sleep formula that I've seen on the sleep formula that I've seen on the sleep formula that I've seen on the planet. It's got eight different planet. It's got eight different planet. It's got eight different ingredients including the GABA system. ingredients including the GABA system. ingredients including the GABA system. So Troy is fantastic. So Troy is fantastic. So Troy is fantastic. >> We also have a practitioner ecosystem. >> We also have a practitioner ecosystem. >> We also have a practitioner ecosystem. So, if you're a practitioner, you can So, if you're a practitioner, you can So, if you're a practitioner, you can sign up for our practitioner account. sign up for our practitioner account. sign up for our practitioner account. You can either buy for your office or we You can either buy for your office or we You can either buy for your office or we have direct shipping. Um, we have a huge have direct shipping. Um, we have a huge have direct shipping. Um, we have a huge portal and ecosystem that I've developed portal and ecosystem that I've developed portal and ecosystem that I've developed over the years with with my team. So, over the years with with my team. So, over the years with with my team. So, that's at prescriptions.com. that's at prescriptions.com. that's at prescriptions.com. And then the nonprofit is called health And then the nonprofit is called health And then the nonprofit is called health optimization medicine and practice or optimization medicine and practice or optimization medicine and practice or home hope for short. It's homehop.org home hope for short. It's homehop.org home hope for short. It's homehop.org and there you can find if you're and there you can find if you're and there you can find if you're interested in training, we have CME interested in training, we have CME interested in training, we have CME certified courses. Um, we have a whole certified courses. Um, we have a whole certified courses. Um, we have a whole ecosystem there that's very much aligned ecosystem there that's very much aligned ecosystem there that's very much aligned with with functional medicine as well. with with functional medicine as well. with with functional medicine as well. Um, and then where else? I think you Um, and then where else? I think you Um, and then where else? I think you know on our website on the know on our website on the know on our website on the transcriptions website there's a lot of transcriptions website there's a lot of transcriptions website there's a lot of information on the sympathetic spiral of information on the sympathetic spiral of information on the sympathetic spiral of doom I've been talking a lot about more doom I've been talking a lot about more doom I've been talking a lot about more a lot more about this and I will a lot more about this and I will a lot more about this and I will continue to be doing it as well and continue to be doing it as well and continue to be doing it as well and again this is not a diagnosis it's a again this is not a diagnosis it's a again this is not a diagnosis it's a pattern that you and I have seen in pattern that you and I have seen in pattern that you and I have seen in clinical practice for years Mark but the clinical practice for years Mark but the clinical practice for years Mark but the key I think is the sequence here is key I think is the sequence here is key I think is the sequence here is mitochondrial support first then mitochondrial support first then mitochondrial support first then sympathetic down regulation and in that sympathetic down regulation and in that sympathetic down regulation and in that order is is the key and then we break order is is the key and then we break order is is the key and then we break the spiral we escape from it long term the spiral we escape from it long term the spiral we escape from it long term using the work that you do and that I do using the work that you do and that I do using the work that you do and that I do in clinical practice. in clinical practice. in clinical practice. >> Amazing. Well thank you thanks for doing >> Amazing. Well thank you thanks for doing >> Amazing. Well thank you thanks for doing it Scott. Thanks for always helping me it Scott. Thanks for always helping me it Scott. Thanks for always helping me when I reach out to you on the hyper when I reach out to you on the hyper when I reach out to you on the hyper oxygen stuff. oxygen stuff. oxygen stuff. >> Oh yeah. And then that finally I have >> Oh yeah. And then that finally I have >> Oh yeah. And then that finally I have one other company called Onebased Health one other company called Onebased Health one other company called Onebased Health >> and that's a company that's involved in >> and that's a company that's involved in >> and that's a company that's involved in the hyperaric space. I know you have a the hyperaric space. I know you have a the hyperaric space. I know you have a chamber now and chamber now and chamber now and >> had some good experiences. >> had some good experiences. >> had some good experiences. >> Yeah. Well, thanks God. Thanks for what >> Yeah. Well, thanks God. Thanks for what >> Yeah. Well, thanks God. Thanks for what you do and just bringing the science to you do and just bringing the science to you do and just bringing the science to everybody and being dedicated to helping everybody and being dedicated to helping everybody and being dedicated to helping people live a healthier, better life. people live a healthier, better life. people live a healthier, better life. >> Right back at you, Mark. Thanks for >> Right back at you, Mark. Thanks for >> Right back at you, Mark. Thanks for having me. having me. having me. >> If you loved that last video, you're >> If you loved that last video, you're >> If you loved that last video, you're going to love the next one. Check it out going to love the next one. Check it out going to love the next one. Check it out here.